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Ivan Minev -Electronic Tissue Technologies for Nervous System Repair

2008 - 2012, PhD University of Cambridge, United Kingdom

2012 – 2016, Post-doctoral research fellow, École polytechnique fédérale de Lausanne (EPFL), Switzerland

2016 – Group leader at Biotechnology Center of TU Dresden

Research

Electronic tissue technologies may soon enable the replacement or repair of damaged human organs. A regenerative surgeon will place a bioelectronic device inside the patient’s body, where it will blend with host tissues and execute a therapeutic program.  The bioelectronic implant may deliver a battery of physical and biochemical stimuli and replacement cells designed to assist the endogenous ability of the body for repair. Boosting regenerative capacity will have high impact in the injured central nervous system, where failure of self-repair following trauma, stroke  or neurodegeneration can have profound and permanent consequences on the patient’s quality of life. 

Although neuroprosthetic implants have already made an impact at the clinic (e.g. continuous deep bran stimulation can alleviate symptoms in Parkinson’s disease), they do not yet achieve regeneration. Our long term vision is to develop implantable technologies that deliver a permanent therapeutic effect by orchestrating repair in the nervous system. 


To make this possible, we are investigating:

  • micro-technologies (e.g. 3D printing) for integrating soft bio-materials into implantable devices that seamlessly blend with neural tissues.
  • neural interfaces with a wide range of functions (e.g. electrical, optical and pharmacological stimulation, delivery of cells).
  • modulation of the injury environment with spatial and temporal precision as a way to promote regeneration in damaged neural tissues.

Publications

Journal Articles

Ivan R. Minev, Pavel Musienko, Arthur Hirsch, Quentin Barraud, Nikolaus Wenger, Eduardo Martin Moraud, Tomislav Milekovic, Jérôme Gandar, Marco Capogrosso, Rafael Fajardo Torres, Nicolas Vachicouras, Qihan Liu, Natalia Pavlova, Simone Duis, Léonie Asboth, Alexandre Larmagnac, Janos Vörös, Silvestro Micera, Zhigang Suo, Grégoire Courtine, Stéphanie P. Lacour, “Electronic dura mater for long-term multimodal neural interfaces”  Science 347(6218): 159-163 (2015)

Ivan R. Minev, Nikolaus Wenger, Grégoire Courtine, Stéphanie P. Lacour “Platinum-elastomer mesocomposite as neural electrode coating” APL Materials, 3(1): 014701 (2015)

Ivan R. Minev, Pouria Moshayedi, James W. Fawcett, and Stéphanie P. Lacour. "Interaction of Glia with a Compliant, Microstructured Silicone Surface." Acta Biomaterialia, no. 6: 6936-42 (2013)

Daniel J. Chew, Lan Zhu, Evangelos Delivopoulos, Ivan R. Minev, Katherine M. Musick, Charles A. Mosse, Michael Craggs, Nicholas Donaldson, Stéphanie P. Lacour, Stephen B. McMahon, James W. Fawcett. “A Microchannel Neuroprosthesis for Bladder Control After Spinal Cord Injury in Rat”, Science Translational Medicine 5, 210ra155 (2013)

Vandeparre, Hugues, Qihan Liu, Ivan R. Minev, Zhigang Suo, and Stéphanie P. Lacour. "Localization of Folds and Cracks in Thin Metal Films Coated on Flexible Elastomer Foams." Advanced Materials 25, no. 22: 3117-21 (2013)

Delivopoulos, Evangelos, Daniel J. Chew, Ivan R. Minev, James W. Fawcett, and Stephanie P. Lacour. "Concurrent Recordings of Bladder Afferents from Multiple Nerves Using a Microfabricated PDMS Microchannel Electrode Array." Lab on a Chip 12, no. 14: 2540-51 (2012).

Ivan R. Minev, Daniel J Chew, Evangelos Delivopoulos, James W Fawcett, and Stéphanie P Lacour. "High Sensitivity Recording of Afferent Nerve Activity Using Ultra-Compliant Microchannel Electrodes: An Acute in Vivo Validation." Journal of Neural Engineering 9, no. 2: 026005 (2012)

Robinson, Adam P., Ivan Minev, Ingrid M. Graz, and Stephanie P. Lacour. "Microstructured Silicone Substrate for Printable and Stretchable Metallic Films." Langmuir 27, no. 8: 4279-84 (2011)

Dansachmuller, M., I. R. Minev, R. Schwodiauer, S. Bauer-Gogonea, and S. Bauer. "Discharge of Ferroelectrets Upon Ionizing Alpha-Radiation." Dielectrics and Electrical Insulation, IEEE Transactions on 18, no. 1: 64-68 (2011)

Minev, I. R., and S. P. Lacour. "Impedance Spectroscopy on Stretchable Microelectrode Arrays." Applied Physics Letters 97, no. 4: 043707 (2010)

Dansachmuller, M., I. R. Minev, P. Bartu, I. Graz, N. Arnold, and Siegfried Bauer. "Generation and Detection of Broadband Airborne Ultrasound with Cellular Polymer Ferroelectrets." Applied Physics Letters 91, no. 22: 222906-06-3 (2007)

Reviews and Book Chapters

Ivan R. Minev and Stéphanie P. Lacour “Mechanically compliant neural interfaces” in Stretchable Bioelectronics for Medical Devices and Systems, J. Rogers, R. Ghaffari and D-H. Kim (Eds.), Springer,  pages 257-273 (2016)

Sakuma M, Minev IR, Gribi S, Singh B, Woolf CJ, Lacour SP. “Chronic Electrical Nerve Stimulation as a Therapeutic Intervention for Peripheral Nerve Repair”  Bioelectronic Medicine 2:43-8 (2015)

Borton, David, Bonizzato, Marco, Beauparlant, Janine, DiGiovanna, Jack, Moraud, Eduardo M., Wenger, Nikolaus, Musienko, Pavel, Minev, Ivan R., Lacour, Stéphanie P., Millán, José del R., Micera, Silvestro, Courtine, Grégoire “Corticospinal neuroprostheses to restore locomotion after spinal cord injury”  Neuroscience Research 78(0): 21-29 (2014)

Funding

Group Members

You can find a list of current group members here.

Open Positions

Currently there are no open positions. We are however always interested in discussions with enthusiastic people. Please send your CV and why you are interested in our research.

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