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Jochen Guck - Cellular Machines

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"Film about Jochen Guck"
Copyright: Alexander von Humboldt Foundation


Curriculum Vitae

  • 2012 Professor of Cellular Machines, Biotechnology Center, TU-Dresden
  • 2012 Alexander von Humboldt Professor
  • 2012 Principal research scientist, University of Cambridge
  • 2009 Reader, Cavendish Laboratory, University of Cambridge
  • 2007 Lecturer, Cavendish Laboratory, University of Cambridge
  • 2002 Junior group leader, Universit├Ąt Leipzig
  • 2001 PhD in Physics, University of Texas at Austin

Positions

Applicants for ERC Starting Grants and DFG Emmy Noether Fellowships in relevant scientific areas are encouraged to contact me to discuss ideas, and for grant writing support, lab space and leveraging funds.

We are also welcoming inquiries into sabbaticals in our group. Some funding is available to support such endeavors.

Lecture "Introduction to Biophysics"

  • WS 2017/18 (obligatorische Vorlesung im Wahlpflichtvertiefungsgebiet "Soft condensed matter and biological physics")
  • Location: REC/D16
  • Time: Tuesdays, 14:50 - 16:20h - first lecture on 10.10.17
  • Also BIOTEC BioMolEng Master course "Principles of Biophysics"
  • Also BIOTEC NanoBio Maser course "Biophysical Chemistry"
  • Location: CRTD, Auditorium (right)
  • Time: Mondays, 15:00 - 16:30h - first lecture on 9.10.17
  • Prof. Dr. Jochen Guck and Dr. Moritz Kreysing
  • Contact: jochen.guck[at]tu-dresden.de and kreysing[at]mpi-cbg.de
  •  The language of this lecture is English.
Content:

This lecture is an introduction to the physics of biological systems at the molecular and cellular level. In addition to providing all the basic information on this topic, the emphasis is on the physical design principles that living systems use to accomplish various cellular processes, enabling them to sense and react to their environment. A set of case studies aims to demonstrate how physicists' experience of the complex systems can complement experimental investigations by biologists to explain how living systems work, and why biology is the way it is.

  • Cells: What's in a cell? Component molecules. Cellular processes. Significance of Brownian motion and diffusion.
  • Information and Regulation: DNA replication. RNA, transcription and translation. Promotors, repressors and operons, DNA topology. Gene regulatory networks.
  • Protein networks: Sensitivity, specificity, robustness. Enzyme kinetics.
  • Energy: Chemiosmotic theory. Membrane potential, Nernst relation, ion channels and pumps. Metabolism and the synthesis of ATP.
  • Structural elements: The cytoskeleton: mictrotubles, actin filaments, networks and gels.
  • Cell movements and locomotion. Biomechanics. Mechanosensing.
  • Molecular machines: Motor proteins and isothermal ratchets. Mechanochemistry and the Kramers equation. Muscle contraction. Processive motors. Rotary motors.
  • Nerve impulses: Axons and the action potential. Hodgkin-Huxley model. Spiking and bursting.
  • Sensory cells: Hair cells in the ear. Active signal detection and cochlear mechanics. Phototransduction in the retina.
Literature:
  • Biological Physics: Energy, Information, Life, Nelson P (WH Freeman 2003).
  • Physical Biology of the Cell, Phillips, Kondev, Theriot (Garland Science, 2009)
  • Cell Movements, Bray D (Garland 2000).
  • Mechanics of Motor Proteins and the Cytoskeleton, Howard J (Sinauer 2000).
  • Essential Cell Biology, Alberts B et al. (Garland 2003)

Lecture "Biophysical methods"

  • WS 2017/18
  • Location: CRTD Auditorium right
  • Time: Tuesdays, 15:00 - 16:30h - first lecture on 10.10.17
  • Also BIOTEC BioMolEng Master course "Principles of Biophysics"
  • Also BIOTEC NanoBio Maser course "Biophysical Chemistry"
  • Location: CRTD, Auditorium (right)
  • Prof. Dr. Jochen Guck and Dr. Anna Taubenberger
  • Contact: jochen.guck[at]tu-dresden.de and anna.taubenberger[at]tu-dresden.de
  •  The language of this lecture is English.

Lab course "Biophysical methods"

  • Download tutorial information

  • BIOTEC NanoBio Master students
  • Time: March 2017

  • BIOTEC BioMolEng Master students
  • Time: March 2017

  • Physics Master students, SS 2017 (obligatorische Veranstaltung im Physik Master Wahlpflichtvertiefungsgebiet "Soft condensed matter and biological physics")
  • Time: March 2017

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