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Brankatschk Marko - Neuro-glial membranes

since 2020 Chair of Representation Biophysics, BIOTEC, TU Dresden

since 2017 Group Leader BIOTEC, Neuro-glial Membranes, TU Dresden

2016 – 2016 Postdoc (F. Stewart Lab, BIOTEC, TU Dresden)

2006 – 2016 Postdoc (S. Eaton Lab, MPI-CBG Dresden)

2001 - 2006 PhD student (B. Dickson Lab, IMP/IMBA Vienna)

Thesis Title: “Axon Pathfinding at the Drosophila Midline”

 

 

RAB library: http://rablibrary.mpi-cbg.de/cgi-bin/rab_overview.pl

Research

The vast majority of life on earth is poikilotherm (cold-blooded) and directly dependent on ambient environmental temperatures. To endure temperature extremes insects have developed behavioral and metabolic strategies. Fruit flies increase their metabolic rate in response to heat and produce cryoprotective metabolites to counter cold. Recent research identified dietary lipids as metabolic signal cues and structural membrane components essential to increase temperature resistance. Interestingly, flies show temperature dependent selective foraging behavior and prefer calorie rich food enriched with long, unsaturated lipids at low temperatures.


We are interested to find the origin and nature of circulating lipids that regulate temperature dependent metabolism in Drosophila melanogaster. In addition, we seek for lipids that change the transport capacity of Blood Brain Barrier cells, modulate the biophysical properties of neuro-glial membranes and regulate the cognitive capacity of adult fruit flies.


For more information contact: marko.brankatschk[at]biotec.tu-dresden.de and visit our Lab-Website.


Publications

 

'Netrins guide Drosophila commissural axons at short range'; M Brankatschk, B-J Dickson; Nature Neuroscience 9, 188 - 194; 2006.

 

'Distinct protein domains and expression patterns confer divergent axon guidance functions for Drosophila Robo receptors'; B Spitzweck, M Brankatschk, and B-J. Dickson; Cell 140(3) pp. 409 – 420; 2010.

 

'Lipoprotein particles cross the Blood Brain Barrier in Drosophila'; M Brankatschk, S Eaton; J Neurosci.; 30(31):10441-7; 2010.

 

'Effects of diet and development on the Drosophila lipidome'; M Carvalho, J-L Sampaio, W Palm, M Brankatschk, S Eaton & A Shevchenko; Mol Syst Biol.;8:600. doi: 10.1038; 2012.

 

'Lipoproteins in Drosophila melanogaster-assembly, function, and influence on tissue lipid composition'; Palm W, Sampaio JL, Brankatschk M, Carvalho M, Mahmoud A, Shevchenko A, Eaton S.; PLoS Genet.; 8(7):e1002828. doi: 10.1371; 2012.

 

'Delivery of circulating lipoproteins to specific neurons in the brain regulates systemic Insulin signaling'; M Brankatschk, S Dunst, L Nemetschke, S Eaton; eLife; 10.7554/eLife.02862; 2014.

 

'Endogenously tagged Rab proteins: a resource to study membrane trafficking in Drosophila.'; S Dunst, T Kazimiers, F von Zadow, H Jambor, A Sagner, B Brankatschk, A Mahmoud, S Spannl-Muller, P Tomancak, S Eaton, M Brankatschk; Dev Cell.; 4;33(3):351-65. doi: 10.1016; 2015.

 

'Staccato/unc13-4 controls secretory lysoosome-mediated lumen fusion during tracheal tube anastomosis in Drosophila'; S Caviglia, M Brankatschk, E Fischer, S Eaton and S Luschnig; Nat Cell Biol.; 18(7):727-39. doi: 10.1038/ncb3374; 2016.

 

'A temperature-dependent shift in dietary preference alters the viable temperature range of Drosophila'; Brankatschk M, Gutmann T, Brankatschk B, Coskun U, Eaton S.; (biorxiv.org/content/early/2016/06/20/059923, manuscript in preparation); 2016.

 

'Rabs on the fly: functions of Rab GTPases during development'; S Caviglia, D Flores-Benitez, J Lattner, S Luschnig and M Brankatschk; Small GTPases.; doi:10.1080/21541248.2017.127972; 2017.

'A temperature-dependent switch in feeding preference improves Drosophila development and survival in the cold M Brankatschk, T Gutmann, O Knittelfelder, A Palladini, E Prince, Developmental cell 46 (6), 781-793. e4; 2018.

'Rab-mediated trafficking in the secondary cells of Drosophila male accessory glands and its role in fecundity, E Prince, B Kroeger, D Gligorov, C Wilson, S Eaton, F Karch, Traffic 20 (2), 137-151; 2018.

'Crumbs organizes the transport machinery by regulating apical levels of PI (4, 5) P2 in Drosophila', J Lattner, W Leng, E Knust, M Brankatschk, D Flores-Benitez, eLife 8; 2018.​

'Sterols as dietary markers for Drosophila melanogaster'; O Knittelfelder, E Prince, S Sales, E Fritzsche, T Wöhner, M Brankatschk, bioRxiv, 857664; 2019.

'Selective phosphorylation of Akt/Protein-kinase B isoforms in response to dietary cues', LC Trautenberg, E Prince, C Maas, F Honold, M Grzybek, M Brankatschk; Frontiers in cell and developmental biology 7, 206; 2019.

 

Open Positions

We are always looking for PhD students who are interested in our work with drosophila.
Please contact us by Mail: marko.brankatschk(at)tu-dresden.de

Group Members

You can find a list of current group members here

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