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The CMCB welcomes 73 new students


22/10/2018

The Center for Molecular and Cellular Bioengineering (CMCB) is happy to welcome 73 new students for this winter semester at the Institutes Center for Regenerative Therapies Dresden (CRTD), Biotechnology Center (BIOTEC) and Center for Molecular Bioengineering (B CUBE) of TU Dresden. A total of 450 applications were received for the three Master's programmes Molecular Bioengineering (MolBio), Nanobiophysics (NBP) and Regenerative Biology and Medicine (RegBioMed). This year, we welcome students from Germany, South Korea, Russia, India, Nicaragua, China, Italy, USA and Mexico, just to name a few. Five of the new students are Erasmus Mundus Master Nanoscience and Nanotechnology students who have completed their first year of their master studies at KU Leuven/Belgium and are with us for the second year, receiving a double degree at the end.

On Oct. 1, the new students met for a "Welcome Meeting", where the Student Council (FSR CMCB) also introduced itself. Afterwards, they took part in the Beer Hour at the CRTD and a tour through the Neustadt.

 
© Sandra Mattick


DFG priority programme funds innovative eye research in Dresden


12/10/2018

Within the Priority Programme 2127 "Gene and Cell-based Therapies to Counteract Neuroretinal Degeneration" the German Research Foundation (DFG) provides funding of more than one million Euros for three years to four research groups at the Center for Regenerative Therapies Dresden (CRTD) and the Biotechnology Center (BIOTEC), both part of the Center for Molecular and Cellular Bioengineering (CMCB) of the TU Dresden, as well as at the German Center for Neurodegenerative Diseases (DZNE) in Dresden.

The SPP2127 brings together 29 experts in vision research and clinical ophthalmology to develop gene- and cell-based therapies for the treatment of currently incurable blinding diseases in a German-wide network. The funded projects will further strengthen this research direction within the Dresden life science network including pioneering approaches in regenerative therapies utilizing human induced pluripotent stem cells (hiPSC), genome engineering and label-free sorting technologies.

Find here the complete press release


The four research group leaders Dr. Volker Busskamp, Dr. Mike O. Karl, Prof. Dr. Marius Ader und Prof. Dr. Jochen Guck (from left to right) © Friederike Braun


Standardized microgel beads as elastic cell mechanical probes


02/10/2018

To evaluate a patient's state of health, the first blood test is usually based on the analysis of simple parameters such as cell count, shape and size. Another physical parameter that can be used to monitor physiological and pathological changes in cells is the cell's elasticity. This makes it possible to quantify the cell's ability to deform (strain) under a certain force (stress). Following these findings, a lot of different techniques have been developed to analyse cell elasticity. These technologies are able to collect data about stress and strain and to extrapolate cell elasticity, using specific mathematical model. A big problem is that the same type of cell analysed with different techniques gives completely different results. Different results give rise to questions such as: Is the instrument working properly? Are the model assumptions used to analyse the valid data? Are these differences due to some intrinsic properties of the sample? To remove this ambiguity, a standard sample is required. This can then be used to calibrate and validate the measurement.

In a joint project of the Center for Molecular and Cellular Bioengineering (CMCB) Microstructure Facility (MSF) and Prof. Guck's research group, microgel beads have now been presented as a mechanical standard for the first time. The beads are fully characterized and show that they can provide the same results when analysed with completely different mechanical measurement methods. This standard sample was called "cell-like elastic microgel beads" because the beads have a size and elasticity comparable to eukaryotic cells, have a pure elastic behaviour and consist of hydrogel (polyacrylamide). The project group has also developed a method to enable the beads to interact with other cells. These beads can therefore be used as cell-scale sensors in cell clusters, either in vitro or in vivo (more details).

This opens up new perspectives for the analysis of stresses associated with the evolution of biological systems such as organoids, spheroids or organisms. The beads can be used in a variety of applications in biophysics, biology, biomedicine and tissue engineering, and the CMCB Microstructure Facility is open to new scientific collaborations.

Publication
CMCB Microstructure Facility
Guck Lab


Bead production (Top), beads functionalized with proteins (Bottom-Left), beads in zebrafish embryo (Bottom-Right)
© Salvatore Girardo, Nicole Träber, and Jochen Guck


Dr. Salvatore Girardo – Facility Leader of the CMCB Microstructure Facility
© Salvatore Girardo


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