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BIOTEC Forum 2012 successfully realized


08/12/2012


Poster session at the BIOTEC forum. ©BIOTEC

More than 300 international scientists met on December 6 and 7, 2012 at the BIOTEC forum. They exchanged latest research results in the areas of Bioinformatics and Computational Biology. Since 2007, the forum is organized every year by the Biotechnology Center of the TU Dresden (BIOTEC) as an open platform, which connects the ten Dresden research groups with international experts.
In the auditorium of the CRTD, 18 talks were presented by top-class speakers, like Philip E. Bourne from the University of California, San Diego (USA), Sui Huang from the Institute for Systems Biology, Seattle (USA), Chris Sander from the Memorial Sloan-Kettering Cancer Center, New York (USA), Robert Eils from the German Cancer Research Center (DKFZ) and the Institute for Pharmacology und Molekular Biotechnology of the University Heidelberg, as well as Eugene Myers from the Max-Planck-Institute for Molekular Cell Biology and Genetics Dresden.


New insights into Stem – and Cancer Stem Cell Biology


03/12/2012

Denis Corbeil has published a book with the title “Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology” with the American publisher Springer. The research group leader at the Biotechnology Center (BIOTEC) at the TU Dresden combines in this book 15 essays about the stem cell marker Prominin-1/CD133, which are written by leading scientists including Elisabeth Knust and Wieland B. Huttner from the Max Planck Institute for Molecular Cell Biology and Genetics as well as Christine A. Fargeas from the BIOTEC. Anne-Marie Marzesco from the Hertie Institute for Clinical Brain Research, who is known for her discovery of new membrane vesicles that contain Prominin-1/CD133, also contributed an essay. Prominin-1/CD133 has become one of the most valuable cell surface markers for the identification and isolation of stem cells from different tissues and organs. Expectations for the development of novel therapies through the replacement and regeneration of damaged or diseased tissues based on isolated stem cells have made this field to one of the leading edges on the frontiers of modern medicine. Its expression by cancer stem cells has also brought new horizon in cancer treatments, and this cell surface antigen may be regarded as a target in the eradication of cancers. The medical relevance of Prominin-1/CD133 is also highlighted in the visual system given that mutations in the PROM1 gene cause retinal degeneration.
Link to Publisher


Scholarship for Master’s Student


30/11/2012

Sumeyye Tuncel, a Turkish Master’s student in the CRTD/BIOTEC Master’s Program „Regenerative Biology and Medicine”, can look forward to a scholarship from the Association of Friends and Sponsors of TU Dresden e.V.  She is an exceptional student and will receive the financial support over the course of four months. Suemeyye is currently working on her Master’s thesis titled “Investigating role of enteroviral infection in type 1 diabetes”. In her thesis, she is investigating the role of viruses that have long been considered as one potential environmental factor that may cause this disease. In particular, Suemeyye is looking into the group B coxsackievirus, a member of the enterovirus genus. The connection between this virus and the disease has not been firmly established yet. Hence, more research in this area is important in order to find causes of Type 1 diabetes. 


DNA Origami – Dresden Students successful in international Harvard-Science Competition


16/11/2012

Eight students, six nationalities, five months. This combination results in the “Dresden Nanosaurs”, a team of international students of the master programs Molecular Bioengineering and Nanobiophysics at the Biotechnology Center (BIOTEC) of the TU Dresden. From June until October 2012 they took part in the scientific competition BIOMOD (Bio‐Molecular Design Competition) of the Wyss Institute at the Harvard University in Cambridge/Boston, USA as one of two German teams. Their idea is to design a switchable adhesive system for lipid membrane which consists of three-dimensional folded DNA structure (DNO origami). On November 3rd, 2012 they successfully presented their project in Harvard and won a gold medal for their research work on aggregate, the second place for their overall project and for each of the categories “Best Website”, “Best Presentation”, “Darling of the Public” as well as the third place in the category “Best YouTube Video”.
Further information
http://biomod.net
http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs


Teaching Award for project work in international CRTD/BIOTEC Master’s Program


12/11/2012

The international CRTD/BIOTEC Master’s Program „Regenerative Biology and Medicine” was awarded with the teaching award on November 9, 2012 for its concept of the “Lab Rotations”. The teaching award is sponsored by the Association of Friends and Sponsors of TU Dresden e.V.  and is awarded since 1998 to outstanding and innovative teaching concepts. The „Lab-Rotations“ were awarded with 2.000 € and include project work in international research labs as an alternative to traditional teaching methods. During the lab rotations, the students learn to design and run experiments and thus gain comprehensive experience in experimental work with model organisms, in molecular biology as well as in cell- and organ research.  Six proposals were submitted and four were chosen for the teaching award. This award is supposed to create incentives for the improvement of teaching and inspirations for new ideas and concepts.


Min-protein waves sense the geometry of artificial membranes


05/09/2012

Scientists from Dresden, Boston, and Saarbrücken have found out in a joint study, how certain proteins of enterobacteria Escherichia Coli can sense the orientation and direction of membrane structures. In Escherichia Coli the cell division is managed by FtsZ proteins. Their localization is regulated by another family of proteins, the Min-proteins. In order to closely study the spatial and temporal behavior of the Min-proteins, scientists of the Biotechnology Center of the TU Dresden (BIOTEC) from the lab of Prof. Petra Schwille, created an artificial membrane environment where the proteins can interact. Because these measurements were performed in artificial membranes and not in the biological cell, this work is part of the area of Synthetic Biology that became more and more important in the last years for biological basic research. Petra Schwille, until recently professor at the BIOTEC, is director of the Max Planck Institute of Biochemistry in Martinsried since May 2012. Together with her lab members she will continue the research of Min-proteins and Synthetic Biology.

In Escherichia coli Min-Proteins oscillate between the ends of the rod shaped bacterium. When reconstituted on artificial membranes, Min-proteins form parallel and propagating waves patterns. On artificial membranes which are confined by gold microstructures, Min protein waves follow the geometry of the membrane. © Jakob Schweizer, Biotechnology Center of the TU Dresden


About 1,600 visitors of the Long Night of Science 2012


13/07/2012

The 10th Long Night of Science – for the first time in the new CRTD building – was a great success. About 1,600 visitors caught up on the research of the DFG Research Center for Regenerative Therapies – Cluster of Excellence (CRTD), the Biotechnology Center of the TU Dresden (BIOTEC), the ZIK BCube, the Paul Langerhans Institute, and the Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) from 18:00-1:00, whose scientists presented their research. At various stations, at lectures and lab tours it was possible for anyone to get an insight into the work of this international research institute and other institutes in the network: The visitors were able to extract with the international students of the School Projects DNA from bananas, learn more about the regenerative capacity of axolotls and zebra fish, also about the forces in the cell or the latest diabetes research.

We thank all the scientists for their commitment to this successful long night of science have made possible.

The next Dresden Science Night will be on 5. July 2013.


Reflective Fish Eyes provide ten-fold Light Efficiency


29/06/2012

Working groups decode eye structure of the elephantnose fish – Findings are relevant for microchip and photonic crystal research

An international research group decoded the eye structure of the elephantnose fish who lives in the muddy black water of Central and Westafrican lakes and rivers. For the first time scientists of the Biotechnology Center of the TU Dresden, the Paul-Flechsig-Institut for Brain Research of the University Leipzig, and 14 other institutes demonstrated a naturally occurring ten-fold light amplification. For this purpose, small parabolic mirrors are located in the retina of the fish, which focus and amplify the incident light before it is detected by the photoreceptor cells. Their findings about the structure of the fish eye and thus improved object recognition could play a role in the field of microchip development and the photonic crystal research. The study "Photonic Crystal Light Collector in Fish Retina Improve Vision in Turbid Water" was published in the American journal Science (DOI: 10.1126/science.1218072). German Press Release


Saxon Biotechnology Symposium 2012 – Showcase of biotechnological Research in Saxony


19/06/2012

About 250 participants from economy and science have regsistered for the Saxon Biotechnology Symposium in BIO CITY Leipzig on June 20th 2012, which is jointly organized by the Biotechnologisch-Biomedizinischen-Zentrum (BBZ) of the University Leipzig and the Biotechnology Center of the TU Dresden (BIOTEC). „Cells as active Sensors“, „Live Cell Analysis“, and „Molecular Medicine and Protein Design“ are this year´s main topics , providing information on the latest developments of this promising technology field in Saxony. German Press Release


CRTD approved as Cluster of Excellence and DFG Research Center


15/06/2012

Dresden’s research center again receives research funds from the excellence initiative

The Center for Regenerative Therapies Dresden (CRTD) has successfully passed the third phase of the excellence initiative. The Cluster of Excellence of the TU Dresden (TUD) and the Research Center of the German Research Foundation (DFG) – the CRTD has qualified to keep these two titles and will be continuously funded for the coming five years. This was confirmed today by the Federal Ministry of Education and Research as well as the German Research Foundation together with the German Council of Science and Humanities. English Press Release


Research together, learn together


08/06/2012

Cooperation agreement between CRTD and Martin-Andersen-Nexö-Gymnasium

During the this year’s “CRTD Summer Conference on Regenerative Medicine“ the DFG Research Center for Regenerative Therapies Dresden – Cluster of Excellence at the TU Dresden and the Martin-Andersen-Nexö-Gymnasium have signed a cooperation agreement. The CRTD will support to broaden the offers of this specialized Dresden grammar school, which specifically promotes mathematics and science to gifted and interested students through advanced teaching modules and projects. In addition the CRTD will complement these efforts by adding insight into the current research of modern life sciences. German Press Release of CRTD


Eugene Myers, pioneer in bioinformatics, will lead new Systems Biology Center


05/06/2012

Max Planck Society founds new center in Dresden

With support from the Klaus Tschira Foundation, the Max Planck Society founds a center for systems biology in Dresden. Eugene W. Myers was appointed director of the center, heading a department at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden and a junior research group at the HITS, the Heidelberg Institute for Theoretical Studies. Further information


Better Cancer Biomarker – picked up from Google and Facebook


15/05/2012

Modified Algorithm of the Search Engine studies 20,000 Proteins

Google delivers good search results because it does not only consider websites but also the hyperlinks between them. A similar strategy is applied in the decision what kinds of proteins in a patient’s tumor are relevant for the course of disease. Researchers at the Biotechnology Center of the TU Dresden together with a research group of the Dresden Universitätsklinikum Carl Gustav Carus have employed a modified version of Google’s PageRank algorithm to study 20,000 proteins according to their influence on the progression of pancreatic cancer. In the study, published in the American journal "PLoS Computational Biology", the researchers have found seven proteins that may help to determine the aggressiveness of a diagnosed tumor with the help of the tumor tissue. This information can help the attending physician to decide whether or not the patient should receive chemotherapy. (DOI: 10.1371/journal.pcbi.1002511) German Press Release


Top-class increase for Dresdner biotechnology


15/05/2012

Biophysicist of TU Dresden awarded with Humboldt Professorship

The biophysicist Jochen Guck (age 39) of the Biotechnology Center at the Technical University of Dresden (BIOTEC) is now officially an Alexander von Humboldt Professor of Cellular Machines. In Berlin, the Humboldt Foundation has awarded six professors with this most valuable international award for research in Germany. Since January 2012, Jochen Guck builds up his laboratory and his research group at the BIOTEC for developing new biophysical approaches in stem cell research, blood cell diagnostics and neuroregeneration. For this purpose, the Foundation’s prize money of five million Euro for five years is at his disposal.

German Press Release

Press Release of the Alexander von Humboldt-Foundation


Targeted control on the wanted gene


27/04/2012

Natural materials easier to analyse: Researchers of germs develop upgraded DNA method

Target-oriented exchange of DNA sections instead of hard search: German and Chinese researchers have developed a method of direct isolation of genetic information from extensive mixtures of different germ species. Certain substances, which are produced by germ and are used medically for example as antibiotics or chemotherapeutic agents, are easier to produce in the laboratory with the help of the new method. Now, the researchers describe these new developed method in the trade journal Nature Biotechnology (DOI: 10.1038/nbt2183).

German Press Release of BIOTEC

German Press Release of the Helmholtz Centre of Infection Research


German Research Foundation supports two new Technology Platforms at biomedical Research Institutes of the TU Dresden


16/02/2012

At the DFG Research Center for Regenerative Therapies Dresden – Cluster of Excellence of the TU Dresden (CRTD) as well as at the Biotechnology Center of the TU Dresden (BIOTEC) the German Research Foundation (DFG) supports two new technology  platforms which will each establish a cross-institutional service- and device pool of the highest scientific standards. Each of these research centers will be supported with 450,000 € for three years. A total of 57 applications have been filed nationwide, of which 11 projects will receive funding, two of them alone in Dresden, as announced by the DFG today. 

German Press Release of CRTD/BIOTEC

German Press Release of German Research Foundation


Student of the molecular bioengineering masters program awarded DAAD-Prize 2011


31/01/2012

Shradha Das who completed her master’s studies Molecular Bioengineering in 2011 was awarded the DAAD Prize 2011 for her excellent course achievements and her social engagement. The award is combined with a reward of 1.000 EUR and was handed over by the Rector of the TU Dresden Prof. Hans Müller-Steinhagen on 13 January 2012 during a celebratory event for the best graduates of the TU Dresden 2011.

Shradha Das comes from India and studied within the master program Molecular Bioengineering from 2009-2011. She made her master thesis in Michael Brand’s lab and completed her degree as best International graduate 2011. Her engagement as student representative and her motivation to improve the organization of the master programs of the BIOTEC also led to this award. She is now enrolled in one the International PhD programs offered by the Dresden International Graduate School for Biomedicine and Bioengineering.


Girls' Day 2012 on April 26: Diversity Life Sciences - A career in science!


27/01/2012

Can I enjoy Genom Engineering? What for a career did a biologist who observes today damaged cells that can regenerate one foot of an axolotl? What tasks does a technician in the fish facility have in an institute? If you are interested in answers to these kinds of questions, or just want to get a taste of science, then the DFG Research Center for Regenerative Therapies Dresden/ Cluster of Excellence and the Biotechnology Center of the TU Dresden is the right place for you on April 26 from 14:30pm! Here, researchers from all over the world are working in different areas, like cell biology, biophysics, (regenerative) medicine, or bioinformatics. 
You will have the opportunity to talk with scientists and ask them lots of questions. A tour through our building will also give you an idea about the research taking place. Interested girls can register here for the Girl's Day. 


Humboldt Professorship: Jochen Guck begins his research at the Biotechnology Center of the TU Dresden


10/01/2012

The biophysicist Dr. Jochen Guck (38) currently has started his Humboldt Professorship for cellular machines at the Biotechnology Center of the TU Dresden (BIOTEC). Before, Guck researched at the Cavendish Laboratory at Cambridge University (UK) and will focus at BIOTEC on the development of new biophysical approaches for stem cell research, blood cell diagnostics and neuroregeneration. The award is endowed with five million Euro for five years.


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