Examplepictures of DNA-Structures

Dresden researchers have developed an intelligent algorithm that automatically identifies significant associations between latent variables in big data sets


An international team of scientists led by Dr. Carlo Vittorio Cannistraci, group leader of the Biomedical Cybernetics lab at the BIOTEChnology Center TU Dresden, developed ‘PC-corr’: an intelligent algorithm that can automatically discover key groups of interacting latent variables generating differences in big data. PC-corr has detected important molecular signatures in more than six different fields of omic science (e.g. lipidomics, metagenomics, genomics and mechanomics), a step forward towards combinatorial biomarker discovery in precision medicine.

Press release

photo: © BIOTEC

Prof. Dr. Stephan Grill receives 2.5 Million EUR ERC Advanced Grant


How growing organisms distinguish between left and right

Stephan Grill, Professor for Biophysics at the Biotechnology Center (BIOTEC) of TU Dresden, will be awarded an ERC Advanced Grant worth EUR 2.5 million for his research on “Chiral Morphogenesis”. The workgroup headed by Stephan Grill will investigate the physical mechanisms that enable a growing organism to distinguish between left and right, in order to place certain organs towards the left side and others towards the right side in a growing organism. To this end, the scientists conduct research on the muscle proteins actin and myosin and the physical mechanisms with which these proteins generate forces and torques in order to shape growing organs. “Revealing the mechanisms that give rise to left-right symmetry breaking in embryonic development is one of the great unanswered questions. The aim of this grant is to understand how cellular, tissue-scale and organismal left-right asymmetry arises from molecular interactions. For this purpose, we will combine physics and biology, and treat living systems as physical systems where chiral, and therefore left-right symmetric, forces drive chiral patterning and chiral structure formation in mechanically active biological matter”, Prof. Grill explains. Stephan Grill’s research group at BIOTEC is keen to understand the forces that allow an embryo to grow into a fully structured and formed organism. For this purpose, the group combines several disciplines, among them cell and developmental biology with biophysics and theoretical physics. In 2011, Stephan Grill received an ERC Starting Grant.

Further information: Group page Stephan Grill

The European Research Council funds three TU Dresden scientists with ERC Advanced Grants, the most highly-endowed individual grants on a European level. These are awarded for renowned scientists who break new ground in their respective area of research by conducting high-risk research. Biophysicist Prof. Stephan Gill, physician Prof. Frank Buchholz and chemist Prof. Stefan Kaskel are granted approximately EUR 7.3 million for their research. In the past, TUD has already been awarded four ERC Advanced Grants.

BIOTEC welcomes new research group leader Dr. Elisabeth Fischer-Friedrich


Since March 20, 2017 - Elisabeth Fischer-Friedrich joins the BIOTEC as new group-leader. The physicist will work on the active rheology of the cytoskeleton by analyzing the material stiffness of cells. The group wants to establish a new approach to cell mechanics characterizing cells as an active pre-stressed material. Unlike inanimate matter, cells contain molecular force generators that produce active contractile stresses in the cellular material. In cell mechanical probing, the contribution of these active stresses has been mainly disregarded. As molecular force generators produce active contractile stress in cellular material, physical concepts for inanimate matter need to be extended to capture material properties of cells. This results in a better understanding of cell migration and the development of tissues. Furthermore, the group works on the development of theoretical and experimental tools for the quantification of active material properties of cells.

In 2009, Elisabeth Fischer-Friedrich obtained her PhD-degree from the Max Planck Institute for the Physics of Complex Systems. Afterwards, she worked as a Postdoc at the Weizmann Institute in Israel. In Dresden, she worked as a Postdoc with affiliations to the Max Planck Institute of Molecular Cell Biology and Genetics and the Max Planck Institute for the Physics of Complex Systems. “Dresden is an excellent location for researchers in the field of Biophysics, as it gathers so many experts not only in BIOTEC but also in several other institutes on the campus. Dresden has a long tradition of biologists and physicists working together and achieving outstanding results in quantitative biology”, she says.

The recruiting of Elisabeth Fischer-Friedrich was facilitated by funds of the Alexander von Humboldt Professorship of Prof. Jochen Guck (BIOTEC). Her intended projects are an essential part of the envisaged cluster of excellence “Physics of Life” which is coordinated by Prof. Stephan Grill (BIOTEC).

photo: © BIOTEC

BIOTEC welcomes new research group leader Dr. Marko Brankatschk


Since the beginning of 2017, Dr. Marko Brankatschk supports the BIOTEC as the leader of the research group “Neuro-glial membranes”. Using the animal model Drosophilia (fruit fly), he investigates their lipid dependent metabolism and its regulatory role on neuro-glial membranes. Recent research on Drosophilia identified dietary lipids as metabolic signal cues and showed the influence of the quality of dietary fat on the formulation of their endogenous lipidom: “I am interested in finding the origin and nature of circulating lipids that regulate metabolism in Drosophilia melanogaster. In addition, we seek for lipids that change the transport capacity of Blood Brain Barrier cells and regulate the cognitive capacity of adult fruit flies.” Answers to these and other questions help to understand complex biological processes including aging or the pathogenesis of neurodegenerative diseases.

The research group is building up right now.

In 2006, Marko Brankatschk obtained the doctoral degree at the IMP/IMBA Vienna, focusing on the topic „Axon Pathfinding at the Drosophila Midline”. From 2006-2016 he worked as a Postdoc in the lab of Suzanne Eaton at the MPI-CBG Dresden, afterwards he supported the research group of Francis Stewart at BIOTEC Dresden. From 2007-2009 his work was awarded with an EMBO Long-Term Fellowship. Since the beginning of 2017, Marko Brankatschk is now working as a group leader at BIOTEC. He is very happy to remain faithfully with the science location Dresden: “The huge interdependence of basic and clinical research and the accumulation of experts on lipid-research make Dresden a great place for scientists. Furthermore, the grants and fellowships for young researchers offered by TU Dresden are very supportive.”

photo: © BIOTEC

System accreditation of TU Dresden certifies the quality of teaching at BIOTEC/CRTD


From 2012 – 2015, TU Dresden went through a system accreditation process which examines the quality of study programms. In this context, the international courses of study at the BIOTEC/CRTD (”Regenerative Biology and Medicine“, ”Nanobiophysics“ and ”Molecular Bioengineering“) were officially accredited on February 3, 2017 (initially until September 30, 2018). The system accreditation serves the internal quality assurance of TU Dresden and certifies the high demands BIOTEC and CRTD make towards their teaching. This accreditation especially matters for international applicants as for some scholarships it’s necessary to apply for accredited courses of study.

Start of Application period for international Master’s programs at the BIOTEC/CRTD


The starting signal is given. Until May 31, 2017 – interested parties can apply for the three Master’s programs Regenerative Biology and Medicine, Molecular Bioengineering and Nanobiophysics. Applicants can expect a first-rate study environment at the Dresden BioCampus, internationally renowned professors, a close integration of theory and practice, access to high-end devices and programs customized to their needs (Lab Rotation). Small study groups and an individual supervision optimize the learning success. All three courses of study prepare for a (scientific) career in the field of life sciences (biomedicine, biotechnology, biophysics).

>>Online application<<

BIOTEC team awarded with gold project at BIOMOD


A team formed by eight students of the master programs Molecular Bioengineering and Nanobiophysics (BIOTEC, Technische Universität Dresden) and supervised by the research group leader Dr. Hans-Georg Braun (IPF) was awarded with the gold project category in the 2016 edition of BIOMOD. This edition was celebrated during the weekend of the 29th and the 30th October and took place in the University of California, in San Francisco (United States of America).

BIOMOD is an annual biomolecular design competition for students organised by the Wyss Institute. 30 teams from all over the world participate by designing and developing a project. This involves finding financial support and publishing the results in a website, a live presentation and a short video, apart from performing experiments. Teams from Dresden Dresden DNAmic (2014), Dresden Nanormous (2013), and Dresden Nanosaurs (2012) were also successful in previous editions of this contest. This year’s edition was won by Tiny Trap, a team from the University of New South Wales, in Australia.

The project developed by the team “I, nanobot” consisted of a micro-sized device capable of transport and deliver a cargo in a controlled manner. It was the result of linking a magnetic Dynabead®, which allows the external control of the movement with a variable magnetic field, to a vesicle for the transportation and delivery of the cargo. The linkage of these two functional parts was achieved using DNA origami technique. Targeted drug delivery and biosensing are some of the possible applications that this device might have in the fields of medicine and molecular biology.

Picture: Team I, nanobot. From left to right: Timothy Esch, Shikhar Gupta, Dr. Braun, Renat Nigmetzianov, Dmitry Beliaev (top); Yara Alsadaawi, Foram Joshi, Judit Clopés and Juliana Hilliard (bottom).

Further information: https://inanobotdresden.github.io/index.html

Annual CRTD/BIOTEC Master Graduation Ceremony on October 28


On October 28,  52 Master's graduates (Regenerative Biology and Medicine (CRTD), Molecular Bioengineering (BIOTEC) and Nanobiophysics (BIOTEC)) received their certificates and mortarboards. In the auditorium and foyer, they celebrated together with families, friends and CRTD members. The CRTD and BIOTEC wish all graduates a great future!

Further information on our Master’s programs: http://www.biotec.tu-dresden.de/teaching/masters-courses.html

Picture: © CRTD

BIOTEC group leader Dr. Carlo Cannistraci appointed TUD Young Investigator


On October 25, 2016 – Dr. Carlo Cannistraci received his certificate of appointment. He is the eighteenth researcher at TU Dresden who is appointed TUD Young Investigator. Dr. Cannistraci studied Bioengineering in Milan (Italy). His PhD with a specialization in Computational, Systems and Network Biology he completed at the Scuola Interpolitecnica di Dottorato (SIPD). Following postings at the University of California San Diego (UCSD) and King Abdullah University of Science and Technology (KAUST), in Jeddah (Saudi Arabia), he is leading a research group on Biomedical Cybernetics at the Biotechnology Center of TU Dresden since 2014.
Picture: Dr. Carlo Cannistraci with TUD Rector Prof. Dr. Hans Müller-Steinhagen © Cindy Ullmann


Freigeist Fellowship supports Dr. Ivan Minev in using 3D printing to find ways to repair damage in the human body


Dr. Ivan Minev, research group leader at the BIOTEC/CRTD, has been awarded a Freigeist Fellowship from the VolkswagenStiftung. This five-year, 920.000 EUR grant will enable him to establish his own research team. The ‘Freigeist’ initiative is directed toward enthusiastic scientists and scholars with an outstanding record that are given the opportunity to enjoy maximum freedom in their early scientific career.

Press release

Photo: © CRTD

From Rigid to Flexible - A physical mechanism to make the transport of cellular cargo efficient and specific


Capture of a vesicle by an endosome by the tethering factor EEA1 binding Rab5. Active Rab5 (shiny blue particles) induces a change in flexibility of EEA1 (green filaments) generating an entropic collapse force that pulls the vesicle toward the target membrane to dock and fuse. Author: Mario AvellanedaIn order for cells to function properly, cargo needs to be constantly transported from one point to another within the cell, like on a goods station. This cargo is located in or on intracellular membranes, called vesicles. These membranes have a signature, and only those with the correct signature may fuse with the membrane of another organelle into one compartment. The membrane itself must be recognized by a target membrane, which employs long tethering proteins to find its match.

David Murray and Marcus Jahnel from the labs of Marino Zerial at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and Stephan Grill at the Biotechnology Center of the TU Dresden were curious to find out how these large tether proteins are able to recognize the signature of a membrane compartment and pull it in in order for the small fusion proteins to engage. They and their colleagues discovered that when the vesicle docks by an active protein called Rab5, GTPase, this protein is sending a message along the rigid tether protein to become flexible. This change in flexibility results in a force that starts the vesicle’s trip towards the target membrane to initiate docking and fusion. This newly found mechanism is published in the journal Nature and intuitively explains how traffic within the cell can be efficient and selective, and resolves a paradox of sizes.


Original Publication:
David H. Murray & Marcus Jahnel, Janelle Lauer, Mario J. Avellaneda, Nicolas Brouilly, Alice Cezanne, Hernán Morales-Navarrete, Enrico D. Perini, Charles Ferguson, Andrei N. Lupas, Yannis Kalaidzidis, Robert G. Parton, Stephan W. Grill and Marino Zerial: An endosomal tether undergoes an entropic collapse to bring vesicles together.
Nature, 24 August 2016, doi: 10.1038/nature19326

Further information: Group page Stephan Grill

Photo: Capture of a vesicle by an endosome by the tethering factor EEA1 binding Rab5. Active Rab5 (shiny blue particles) induces a change in flexibility of EEA1 (green filaments) generating an entropic collapse force that pulls the vesicle toward the target membrane to dock and fuse.
Author: Mario Avellaneda



Prof. Dr. Michael Brand elected as EMBO Member


BIOTEC and CRTD research group leader Prof. Dr. Michael Brand, founding director and speaker of the CRTD from 2005 to 2014, was elected as new EMBO Member. The European Molecular Biology Organization (EMBO) elects new members annually in recognition of their excellent contributions to scientific understanding. Their selection is a tribute to their research and achievements. This prestigious honour again demonstrates the high performance and quality of CRTD researchers.  

“I am delighted by the addition of 58 outstanding scientists to our membership. I would like to congratulate them and welcome them to the EMBO community”, says EMBO Director Maria Leptin. “By serving the principles of excellence and integrity through their views and actions, they make invaluable contributions to science and society.”  

EMBO is an organization of more than 1700 leading researchers world-wide, including 84 nobel laureates, that promotes excellence in the life sciences. The major goals of EMBO are to support talented researchers at all stages of their careers, stimulate the exchange of scientific information, and help build a European research environment where scientists can achieve their best work.

Further information: http://www.embo.org and http://www.crt-dresden.de/research/crtd-core-groups/brand.html

CRTD, BIOTEC and B CUBE again part of Dresden Long Night of Sciences on June 10, 2016


On June 10 - CRTD, BIOTEC and B CUBE will again present their work at the Dresden Long Night of Sciences. On four levels we will have a varied program (presentations, talks and hands-on activities) from 6 pm - 1 am. We are looking forward to welcoming you!

Location: CRTD, Fetscherstraße 105, 01307 Dresden


Complete program: http://www.wissenschaftsnacht-dresden.de/programm/

The new Grant Office for B CUBE, BIOTEC and CRTD opens its doors


The Grant Office (GO) was established in February 2016 to support scientists at B CUBE, BIOTEC and CRTD in acquiring grants for basic and applied research. GO was initiated by Prof. Michael Brand and is funded by the State of Saxony for three years to establish a specialist team for grant application management. GO also aims to strengthen the profile of the Dresden Biocampus in local, national and international networks.
The Grant Office is located at the CRTD (3rd floor south, room 3.137).
Contact:  grant_office(at)lists.biotec.tu-dresden.de   

photo: GO Team (Gary Jennings, Maria Begasse, Nambirajan Govindarajan) © CRTD

BIOTEC/CRTD again part of Dresden Seniors Academy (summer term 2016)


BIOTEC & CRTD are again part of Dresden Seniors Academy with five different lectures. All lectures are held in German.


“Die Regeneration des zentralen Nervensystems.  Der Fisch kann es! Warum ich nicht?“
Dr. Michell M. Reimer
Wednesday, April 13, 2016
10.00-11.30 am

“Optische Pinzetten: Moleküle in der Lichtzange“
Christoph Ehrlich
Wednesday, May 11, 2016
10.00-11.30 am

 “Eine kleine Geschichte der Mikroskopie“
Dr. Ruth Hans
Wednesday, June 15, 2016,
10.00-11.30 am
(Seminar room 3)

“Die Vermessung des Denkens“
Dr. Alexander Garthe
Wednesday, August 17, 2016
10.00-11.30 am
(Seminar room 3)

“Futter für das Denken: der Zusammenhang zwischen Ernährung und Hirnfunktion“
Prof. Dr. Gerd Kempermann
Wednesday, September 7, 2016
10.00-11.30 am

DFG-Forschungszentrum für Regenerative Therapien TU Dresden
Fetscherstraße 105
01307 Dresden

Further information:

Synergy effects through new joint Technology Platform of CRTD, BIOTEC and B CUBE


From now on,  11 core facilities of the CRTD, BIOTEC and BCUBE are presented on one webpage as the joint Technology Platform. This structural improvement includes an optimized user navigation, an improved access to information and details as well as the standardized booking system . In the course of last year, the development of the this new internet presence has both involved administration and IT staff of all three research institutes as well as researchers and technical assistants of the core facilities. Currently, the core facilities are serving more than 130 research groups that are able to gain from these improvements with immediate effect. The Joint Technology Platform is funded by third party financing through the German Research Foundation (DFG), the Federal Ministry of Education and Research (BMBF), the Free State of Saxony, the European Union EFRE initiative and the Technische Universität Dresden.

Further information, overview of the services offered & access to the booking system:


Guest studies: CRTD and BIOTEC open its lectures for asylum seekers


We are inviting asylum seekers to become a guest student at the BIOTEC/CRTD. All relevant information and the application form can be found here:

Guest studies for asylum seekers

SPACE-P’s BIOTEC team wins bronze medal in Boston in the international student competition iGEM


A team of master students at the BIOTEC can be happy: their work for the international student competition iGEM was awarded with the bronze medal in September at the in Boston. The International Genetically Engineered Machine competition (iGEM) is the premiere undergraduate Synthetic Biology competition. Student teams are given a kit of biological parts at the beginning of the summer from the Registry of Standard Biological Parts. Working at their own schools over the summer, they use these parts and new parts of their own design to build biological systems and operate them in living cells. 259 multidisciplinary teams with over 2700 attendees from all over the world presented their projects at the iGEM Giant Jamboree on 24-28 September 2015 in Boston, Massachusetts.

Most of the BIOTEC team members are students of the international Master’s program Molecular Bioengineering. Supervision was mainly under the Chair of Genomics at the BIOTEC. In their project “SPACE-P” for “Structural Phage Assisted Continuous Evolution of Proteins”, the team proposes an alternative way of identifying potential protein binding partners which could replace antibodies for certain applications. The goal was to speed up screening for peptides capable of interacting with other proteins. This should be achieved by combining the power of phage display with a bacterial two hybrid system under constant mutational pressure in a chemostat. The cyclic process of mutation and selection should result in finding a potent binding partner for a target protein in less than three days. A much more detailed description of the project and the team can be found at: http://2015.igem.org/Team:TU_Dresden

Dec 11, 2015: Certficates for the best graduates 2015 of TU Dresden


On Friday December 11, 2015 - the best graduates 2015 of TU Dresden have been awarded a certificate of honors by the Rector of the University. All in all, there were 97 best graduates from approx. 6000 graduates in 2015. For the BIOTEC/CRTD Master's programs, Maria Elsner, Lisa Kube and Jana Sievers from the Master's program Molecular Bioengineering participated and were handed-over the certificate "Ehrenfried-Walter-von-Tschirnhaus" meant for the best graduates in the field of mathematics and life science. Alexandr Dibrov from the Master's program Nanobiophysics as well as Lara Maronne and Philip Franke of the Master's program Regenerative Biology and Medicine could not join but will be receiving their certificate by post. Congratulations to all of them!

Dr. Jörg Mansfeld receives 1.5 Million EUR ERC Starting Grant


Dresden biologist Dr. Jörg Mansfeld receives 1.5 Million EUR ERC Starting Grant to support his cancer research

Jörg Mansfeld, Emmy Noether Group Leader at the Biotechnology Center of TU Dresden, was awarded a prestigious and highly competitive Starting Grant from the European Research Council (ERC), which will provide 1.5 Million Euros over 5 years to support his research on cell cycle and redox regulation.  With Starting Grants, young, promising scientists who have the proven potential of becoming independent research leaders, are supported.

Photo © Jörg Mansfeld

Prof. Dr. Stephan Grill receives the 2015 Sackler Prize in Biophysics endowed with US$ 50.000


With this prize, Stephan Grill is honored for excellent research in the field of mesoscopic physics of cell structure and dynamics. He receives this award for his outstanding contributions to the physics of intracellular actomyosin networks and the discovery of the mechanism of chiral morphogenesis. The Raymond and Beverly Sackler International Prize for Biophysics was established through the generosity of Dr. Raymond and Mrs. Beverly Sackler at Tel Aviv University in Israel. Professor Grill will receive the prize in person at Tel Aviv University on December 15 this year.

Further information: https://english.tau.ac.il/sackler_prize_in_biophysics

Press Release

Photo: © Katrin Boes, MPI-CBG

BIOTEC Professor Stephan Grill Appointed Max Planck Fellow


The Dresden-based biophysicist Stephan Grill combines combines biology with physics and theoretical physics to bridge the gap between the molecular, cell and tissue mechanical understanding of morphogenesis. Stephan Grill and group made the fundamental discovery of torque-generation inside the actomyosin cortex, which has an impact on early developmental processes like the establishment of the left-right body axis.

Stephan Grill (41) studied Physics at the Ruprecht-Karls-Universität Heidelberg and worked at the European Molecular Biology Laboratory (EMBL) afterwards. He did his doctorate at the TU München in 2002 and continued his research as a postdoc at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden from 2001 – 2004. Until 2006 Stephan Grill worked at the Lawrence Berkeley National Laboratory in the U.S. and subsequently joined the Max Planck Institute for the Physics of Complex Systems and at the MPI-CBG from as research group leader. Since 2013, he is Professor of Biophysics at the Biotechnology Center of the TU Dresden.

So far, Stephan Grill has published more than 50 publications, many of them in highly recommended scientific journals. He has been awarded several prizes for his scientific success, e.g. 2009 the Award for Research Cooperation and Highest Excellence in Science (ARCHES) of the German Ministry of Education and Research and the Minerva Foundation. In 2010, Stephan Grill received the EMBO Young Investigator Award and in 2011 the ERC Research Grant as well as the Paul Ehrlich and Ludwig Darmstädter Young Investigator Prize. In 2013, he was awarded the Binder Innovation Prize of the German Society for Cell Biology.

The Max Planck Fellow Programme of the Max Planck Society was established in 2005 in order to promote the cooperation between outstanding university professors and Max Planck Society researchers. The appointment of university professors as Max Planck Fellow is limited to a five –year period and also entails the supervision of a small research group at a Max Planck Institute. The funding can be extended for 5 more years on a one-off basis.

Apart from Prof. Grill, Prof. Elly Tanaka, Prof. Michele Solimena, Prof. Michael Ruck and Prof. Roland Ketzmerick have been appointed Max Planck Fellows during the last years. In Germany, there are approximately 40 Max Planck Fellows, 5 of them at the TU Dresden.



Zuwachs für die Dresdner Biotechnologiebranche: Die Zellmechanik Dresden GmbH, ein Spin-off der TU Dresden, bringt ein Forschungsgerät auf den Markt, das u. a. den mechanischen Fingerabdruck von Blut bestimmen kann. Die Unternehmensgründung basiert auf der Entwicklung eines neuartigen Verfahrens zur Bestimmung der mechanischen Eigenschaften von Zellen in der Arbeitsgruppe von Prof. Dr.  Jochen Guck am Biotechnologischen Zentrum der TU Dresden (BIOTEC). Die Forschungsarbeiten wurden von der Europäischen Union, der Alexander von Humboldt-Stiftung und dem Freistaat Sachsen gefördert. Zwei der Erfinder der Methode bilden mit drei weiteren Mitgliedern das Gründungsteam des Unternehmens.

 „An Ostdeutschlands einziger Exzellenz-Universität, der TU Dresden, wurde einmal mehr zukunftsweisende Grundlagenforschung betrieben. Umso mehr freue ich mich, dass auch aus diesem Umfeld im Bereich der Biotechnologie Projekte zur Marktreife gebracht werden und neue Unternehmen entstehen – auch ermöglicht durch die effektiven Technologietransfer-Mechanismen am Standort“, sagt Heike Lutoschka, Abteilungsleiterin Wirtschaftsstrategie und Marketing im Amt für Wirtschaftsförderung der Landeshauptstadt Dresden.

Neues Verfahren revolutioniert die Diagnostik von Krankheiten – Aussagen über den Gesundheitszustand sind früher und einfacher möglich
Im Gegensatz zu herkömmlichen Verfahren zur zerstörungsfreien Analyse von Zellpopulationen werden für die Methode „Real-Time Deformability Cytometry“ (RT-DC) weder Antikörper noch Fluoreszenz oder andere externe Biomarker benötigt. Die Information liegt in der Zelle selbst: „Die Zellen haben mechanische Eigenschaften, anhand derer sie unterschieden werden können. Krebszellen sind beispielsweise leichter verformbar als gesunde Zellen. Das können wir ertasten“, sagt Professor Guck.
Eine Hochgeschwindigkeitskamera, die mehrere tausend Bilder pro Sekunde schießt, stellt dabei Deformationen jeder einzelnen Zelle in Echtzeit fest. „So können wir die mechanischen Eigenschaften von mehreren hundert Zellen pro Sekunde messen. Das erlaubt uns in einer Minute Analysen, für die vergleichbare Technologien eine Woche benötigen“, erläutert Dr. Oliver Otto. So gelingt die Charakterisierung aller Blutzellarten inklusive Aktivierungsstatus der Zellen in nur 15 Minuten. Durch den hohen Durchsatz an Zellen reicht dafür ein Tropfen Blut aus. Etablierte Ansätze der medizinischen Diagnostik könnten damit durch einen einfachen und direkt zugänglichen Parameter ergänzt und damit die Anzahl zusätzlicher und teurer Analysen reduziert werden. „Das ist gerade bei dem mechanischen Fingerabdruck weißer Blutzellen entscheidend, der ein Abbild des Immunsystems und dessen Zustands ist “, so Dr. Otto weiter.

Preise und Auszeichnungen verweisen auf  den Stellenwert des Verfahrens
Neben vielen anderen Preisen ist das Gründungsprojekt im Juli dieses Jahres mit dem 2. Platz beim Sonderpreis „Emerging Industries“ im Rahmen des europäischen C3-Projektes ausgezeichnet worden. Diese Auszeichnung ist für herausragende Projekte an der Schnittstelle von Informations- und Kommunikationstechnologie und Life Sciences vergeben worden.
Im Projekt C3-Saxony haben sich die Technologiecluster Silicon Saxony (Mikro- und Nanoelektronik) und biosaxony (Life Sciences) vereint, um gemeinsam die Entwicklung interdisziplinärer Technologien voranzutreiben. Das von der Europäischen Union geförderte Projekt wird vom Sächsischen Staatsministerium für Wirtschaft, Arbeit und Verkehr koordiniert.

Kontakt für Journalisten:
BIOTEC der TU Dresden
Prof. Dr. Jochen Guck
Telefon (03 51) 463 40 349
E-Mail: guck(at)biotec.tu-dresden.de

Zellmechanik Dresden GmbH
Dr. Oliver Otto, Geschäftsführer
Telefon (03 51) 463 40 324
E-Mail: otto(at)zellmechanik.com

Sich selbst heilende Axolotl, Organe aus dem 3D-Drucker, ein begehbares Auge und Elegante Würmer unterm Lego-Mikroskop


Lange Nacht der Wissenschaften: Forschung entdecken und experimentieren

Kann 3D-Druck von organähnlichen Strukturen die Notwendigkeit von Tierversuchen minimieren und die Entwicklungen in der Biomedizin beschleunigen? Inwieweit lässt sich das Wissen über die Selbstheilungskräfte des Axolotls oder des Zebrafisches auf den Menschen übertragen? Diese und viele andere spannende Fragen beantworten Wissenschaftler während der 13. Langen Nacht der Wissenschaft am Freitag, 03. Juli 2015, von 18:00 bis 1:00 Uhr im DFG-Forschungszentrum für Regenerative Therapien Dresden – Exzellenzcluster an der TU Dresden (CRTD), Fetscherstraße 105, 01307 Dresden. Forschungsgruppen des CRTD, des Biotechnologischen Zentrums der TU Dresden (BIOTEC), des Zentrums für Innovationskompetenz B CUBE, des Paul-Langerhans-Instituts (PLID) sowie des Deutschen Zentrums für Neurodegenerative Erkrankungen (DZNE) lassen sich in dieser Nacht über die Schulter schauen, halten Vorträge und laden zum Mitmachen ein. Für Kinder gibt es Extra-Touren zu den Axolotln sowie spannende Entdeckungen unter Mikroskopen. Internationale Studententeams sowie Schüler der CRTD-Partnerschule Martin-Andersen-Nexö-Gymnasium zeigen Experimente.

Die Exponate der Forschungsgruppen des Netzwerkes Biopolis Dresden, die im CRTD gemeinsam in dieser Nacht ausstellen, reichen von der Bioinformatik über die Zellbiologie bis hin zur Biophysik. Viele Stationen aus den Bereichen der regenerativen Therapien und der Biotechnologie bieten Experimente und Einblicke in Forschungsarbeiten an, die zum Ziel haben, neue Therapien für bisher unheilbare Erkrankungen wie zum Beispiel Diabetes oder Demenz zu entwickeln. Wissenschaftler erklären unter anderem, warum bei Zebrafischen Flossen oder Teile des Herzens nachwachsen, zeigen am Mikroskop, wie sich Zellen teilen, biologische Strukturen in 3D gedruckt werden können oder wie sich neue Nervenzellen im erwachsenen Gehirn bilden. Über Ursachen und neue Therapieansätze bei Autoimmunerkrankungen und neurodegenerativen Erkrankungen der Netzhaut informieren die Wissenschaftler der Institute.

Die kleinen Besucher werden auf speziellen Kindertouren durch das CRTD geführt: Sie lernen das Axolotl kennen- der mexikanische Salamander, der nach Verletzungen Arme und Beine nachwachsen lassen kann. Beim  Blick durch das Mikroskop,  werden sie Strukturen entdecken, die mit dem bloßen Auge nicht erkennbar sind.
Darüber hinaus wird es einen eigenen Bereich für Kinder geben, in dem sie kreativ tätig werden und spielerisch experimentieren können.


Das vollständige Programm für die Station 21, Fetscherstraße 105 mit weiteren Angaben zur Kindertour, Vorträgen und Ausstellungen ist im Internet unter www.wissenschaftsnacht-dresden.de nachzulesen.

Scientists open new chapter in cell biology and medicine


Nature Methods publishes innovative method for mechanical screening of biological cells developed in Dresden

An entirely new approach for the mechanical characterization of cells, developed by scientists of the Technische Universität Dresden (TU Dresden), has the potential to revolutionize the diagnosis of a wide range of diseases. Cells, like any other material, have mechanical properties that can serve for their characterization. For example, cancer cells are characteristically more deformable than healthy cells. These mechanical properties can be determined without specialized, costly and time-consuming preparation, which makes them highly attractive for diagnosis and prognosis in medical applications. However, there has so far been a lack of an adequate method to mechanically screen large populations of cells in a short amount of time. Scientists at the TU Dresden have now presented a novel method, which addresses this need and which will help to answer many open questions in biology, physics, chemistry and medicine. The method is now being published in the current issue of Nature Methods.

Press release
Photo: Real-Time Deformability Cytometry (RT-DC) to determine the mechanical fingerprint of blood. Cells flow at a velocity of 10 cm/s from right to left through the microfluidic channel (width oft the image shown: 1.5 mm). The sheath flow from the upper and lower right corners focuses the cells for cell deformability measurements in the narrowest part of the channel. This focusing causes the formation of heart-shaped streamlines as illustrated here by an inverted overlay of many single frames. ©BIOTEC



BIOTEC Junior researcher lays cornerstone for biotech start-up and receives Georg Helm Award


The BIOTEC-student Philipp Rosendahl has received the Georg-Helm-Preis of the Verein zur Förderung von Studierenden der Technischen Universität Dresden e.V. for his diploma thesis “Mechanical Characterization of Suspended Cells in Microfluidic Channels”. The prize is annually awarded to three students of the TU Dresden for great excellence and high impact results of their scientific thesis since 1995. Philipp Rosendahl has conducted his research in the group of Professor Jochen Guck at the Biotechnology Center of the TU Dresden (BIOTEC).

The 28-year old physics student co-developed an innovative method, called real-time deformability (RT-DC), for the analysis of the mechanical properties of biological cells with an unprecedented throughput of over 100 cells/second. Using RT-DC it is possible to obtain a “mechanical fingerprint” of whole blood, which can be used to sensitively assess the health state of patients within minutes. Currently, Philipp Rosendahl continues this project as a PhD student in the research group of Prof. Guck.

The great impact this novel method might have on fundamental and applied research, as well as clinical applications, is becoming evident by an ever-increasing number of scientific collaborations. Encouraged by the feedback of the scientific community and supported by the TU Dresden, the state of Saxony and the EU, Prof. Guck and his team are now setting up a spin-off company to commercialize RT-DC. The company, ZellMechanik Dresden, aims to make this innovative cell mechanical analysis device available to researchers and clinicians all over the world.

Press release
Photo: Philipp Rosendahl ©Susan Rosendahl

Let's torque about sex, baby: How chiral torques break left-right symmetry


A developing organism needs axes for orientation: Where is the top, where the lower part of the body, back and front? A third axis defines where the left and the right side goes. If you look at the sirface of our body, there is a clar axis with a symetrically mirrored left and right side. However, if you look at the inside, the organs are not at all arranged in a symmetric manner. How do cells break the left-right symmetry?

The Grill Lab uncovered a novel activity of the actomyosin cortex in C. elegans at the 4-cell stage: It generates active torques, counter-rotating flows that, in a screw-like motion, facilitate symmetry breaking.

Original paper: Sundar Ram Naganathan, Sebastian Fürthauer, Masatoshi Nishikawa, Frank Jülicher, Stephan W Grill: Active torque generation by the actomyosin cell cortex drives left-right symmetry breaking, eLife, 17 December 2014

Further information

press release by Florian Frisch (MPI-CBG)

BIOTEC Forum 2014: Molecules, Cells, and Tissue – Biomechanics Across Scales


More than 200 international scientists interchange about current research results at the BIOTEC Forum 2014 in Dresden from December 8th to December 9th, 2014. The Forum which is organized by the Biotechnology Center (BIOTEC) and the Center for Innovation Competence B CUBE at the TU Dresden since 2007 is focusing on „Biomechanics across scales – molecules, cells, tissue“ this year. The purpose of the open communication platform is to create worldwide cooperations between the working groups of biomechanics, biophysics, cell and developmental biology.

German Press Release

TUD Team ‘Dresden DNAmic’ successful at the International BIOMOD Contest in Harvard


For the third time in a row, a students team of TU Dresden yesterday reached the second place at an international science contest in Harvard (USA): Under the supervision of cfaed research group leader Dr. Thorsten-Lars Schmidt, twelve students of the BIOTEC master's programs 'Molecular Bioengineering' und 'Nanobiophysics' took part in the annual ‘Harvard Biomolecular Design Competition’ (BIOMOD) in Boston. The interdisciplinary team ‘Dresden DNAmic’ uses the DNA-Origami-technique to create a nanometer-sized photonic circuit with the helices of the genetic code carrier and gold nanoparticles.
In the previous two years, the TUD teams ‘Dresden Nanormous’ (2013) and the ‘Dresden Nanosaurs’ (2012) also reached a second place each. The ‘Dresden DNAmics’ received the third prize in the category ‘Best video’, the first prize for the best website and therefore came on the second place over all. The winner was a team from Australia.

“The target of our project is the production of plasmonic waveguides,” the biochemist Leon Bichmann of the ‘Dresden DNAmic’ Team explains. “The laser light propagates from gold particle to gold particle along the path provided by the DNA origami. We want to construct photonic nanocircuits which can guide signals much faster than electric signals in a wire. The DNA will be used in a completely new context, not as a carrier for genetic information but as a building material.” Applications might include smart phones and computers as well as medical technologies.

The BIOMOD jury will judge not only the project itself, but also the project’s website, a live presentation and a video clip. Furthermore, the students had to find sponsors of industry and science for their project. “Also at the ‘Long Night of Science’ and at the senior academy in Dresden, we presented the concept of our DNA circuits”, team member Jana Sievers remembers. “Since January 2014, we worked on the project – a good exercise also for the master thesis”, the biotechnologist says.
The participation in this competition was initiated by TUD's 'B CUBE – Center for Molecular Bioengineering' and 'Biotechnology Center (BIOTEC)'. The international competition, in which 30 teams of the whole world participate, is organized by the Wyss Institute for Biologically Inspired Engineering at Harvard University. From 2010 to 2013, Dr. Thorsten-Lars Schmidt had spent his Post-Doc-period there, before he moved to Dresden as a research group leader of the Center for Advancing Electronics Dresden (cfaed), the Cluster of Excellence for Electronics of Technische Universität Dresden (TUD).

Photo: BIOMOD students ©BIOTEC

BIOTEC Researcher is one of the „Highly Cited Researchers 2014”


Thomson Reuters publishes ranking list of outstanding researchers

The ranking list „Highly Cited Researchers 2014“ by Thomson Reuters named Dr. Michael Kuhn of the Biotechnology Center at the TU Dresden (BIOTEC) as one of the worldwide most cited researchers in the area biology and biochemistry. The American media company has evaluated the citation of scientific publications from 2002 until 2012 and listed 3,215 distinguished researchers in 21 different research areas in total.

Press Release

Photo: Michael Kuhn from the BIOTEC is one of the "Highly Cited Researchers 2014" ©BIOTEC

New cells is what the human needs: More than 1,880 Visitors visited the CRTD during the Long Night of Science


Is it possible to determine the physical characteristics of cells with the power of light, running water or tiny feathers? Why is the look of a mouse different to a fly? Answers to these and other fascinating questions were given to more than 1,600 visitors at the CRTD during the 12th Long Night of Sciences. Scientists of the DFG Research Center for Regenerative Therapies – Cluster of Excellence (CRTD), the Biotechnology Center of the TU Dresden (BIOTEC), the ZIK BCUBE, the German Center for Diabetes Research/Paul Langerhans Institute (DZD/PLID), the German Center for Neurodegenerative Diseases (DZNE), the German Center for Neurodegenerative Disease (DZNE), TU Chemnitz, the Life Science Incubator (LSI), the CRTD cooperation school Kooperationsschule Martin-Anderson-Nexö-Gymnasium (MANOS), the School Projects, and the Nanomod students presented their research on July 5th, 2014 from 6pm – 1 am: At various stations, lectures, and children tours it was possible for anyone to get an insight into the work of the CRTD and other institutes in the network. The visitors were able to catch the criminal with the aid of finger prints and blood samples, they learned more about the regenerative capacity of Axolotls and zebrafish, they tried to get along in the darkness of blind persons as well as learned about forces in the cell or latest diabetes and neurodegenerative research.

We want to say "Thank you" to all the scientists for their contributions to this successful Long Night of Science. They made this diverse program possible.
The next Dresden Science Night will be on July 3rd, 2015.

 Photo: CSI – Dresden: Catch the criminal! ©CRTD

European Funding: On the Road to Diagnosis Device for Blood Cells


BIOTEC Professor transfers research results into commercial application

Professor Jochen Guck of the Biotechnology Center of the TU Dresden (BIOTEC) will initialize the commercialization of a new developed technology with the assistance of a “Proof of Concept Grants”, which is awarded by the  European Research LZ zu viel Council (ERC). The aim is to measure with an innovative device the mechanical features of cells for detecting early the disease of sepsis. For twelve months, 150,000 Euros are available for the physicist to evaluate the commercial application of the new method and to arrange the marketing.

German Press Release

Axolotl, „CSI BIOTEC“, and Drums Alive – new cells is what the human needs


Long Night of Science: Discover Science and Experiments

Is it possible to determine the physical characteristics of cells with the power of light, running water or tiny feathers? Is it possible to develop methods and new instruments for the clinical diagnostics of infections and diseases from the results? These exciting questions will be answered by scientists in the DFG Research Center for Regenerative Therapies Dresden – Cluster of Excellence at the TU Dresden (CRTD), Fetscherstraße 105, 01307 Dresden during the Long Night of Science on Friday, July 4th, 2014 from 6pm to 1am. Research groups of the CRTD, the Biotechnology Center of the TU Dresden (BIOTEC), the Center for Innovation BCUBE, the Paul Langerhans Institute Dresden (PLID), the German Center for Neurodegenerative Diseases (DZNE), as well as the Sports Medicine of the TU Chemitz will offer a look over their shoulder, give talks and invite visitors to actively participate in experiments. For children, there will be extra tours to the Axolotl. International student teams and students of the CRTD cooperation school Martin-Andersen-Nexö-Gymnasium will show experiments.

Download Photo: On extra tours children can microscope and visit the Axolotl.©CRTD

German Press Release

Program in German

Website of the Long Night of Science

Here is the new LNdW mobile app for Android smartphones.

Here is the new LNdW mobile app for iOS devices.

HFSP Funding for international Research Project at the BIOTEC: Switching Molecular Engines in Cells with Light


The organization „Human Frontier Science Program Organization“ (HFSP) funds an international research cooperation under the direction of Professor Stephan Grill of the Biotechnology Center of the TU Dresden (BIOTEC). Together with Professor Zev Bryant of the Stanford University Schools of Medicine and Engineering (USA), and Professor Alpha Yap of the University of Queensland (Australia), a method is established to switch molecular engines in cells and tissue with light. This cooperation is funded over three years with more than one million US dollars.

German Press Release

Photo: Professor Stephan Grill of the BIOTEC directs the research cooperation funded with more than one million US dollars by the HFSP. ©BIOTEC

FANTOM5 - a Parts List for Cell Type Definition


The FANTOM5 project examines how our genome encodes the fantastic diversity of cell types that make up a human

After several years concerted effort by over 250 researchers in 114 labs based in more than 20 countries and regions, the FANTOM consortium publish a series of coordinated papers, a pair of landmark papers in Nature, and 15 other related papers in 9 journals today(ref.1,2,3). The papers published in Nature describe maps of promoters and enhancers encoded in the human genome, and their activity across the vast wealth of human cell types and tissues of the human body. Part of this concerted work was in particular Dr. Carlo Vittorio Cannistraci, research group leader at the Biotechnology Center at the TU Dresden (BIOTEC), who has created as biomedical cyberneticist theoretical structures out of the numerous data. (Link to the studies in Nature: dx.doi.org 10.1038/nature13182)

German Press Release

Link to the RIKEN Press Release

Photo: In a series of meetings got together the researchers of the FANTOM5 consortium in that took part over 250 researchers in 114 labs based in more than 20 countries and regions. They created the parts list for cell type definition. ©RIKEN

„Sächsischer Biotechnologietag 2014“ – Awards for Research Studies at the Competitive Exhibition


More than 220 researchers and entrepreneurs of biotechnology in Saxony and further federal states as well as European countries have visited the “Sächsische Biotechnologietag 2014” that was organized by the Biotechnology Center at the TU Dresden (BIOTEC) and the “Biotechnologische-Biomedizinische Zentrum” (BBZ) from the university of Leipzig with the assistance of biosaxony e. V. “The new concept of a competitive exhibition in the Saxon biotechnology sector in research, economics, and commercial applications works”, says Professor Michael Schroeder, director of the BIOTEC. Thirteen guest speakers covered the first steps of a researcher for commercializing his research results up to the point of the presentation of successfully established internationally acting enterprises. 29 Saxon industry exhibitors, among them start-ups of the TU Dresden and other scientific institutes, showed their products and technological applications in the foyer of the DFG-Research Center for Regenerative Therapies Dresden – Cluster of Excellence at the TU Dresden (CRTD).

The poster session representedresearch results with a high potential of commercial applications. Joachim Haupt from BIOTEC received the 1. award for his research. Awarded were also Nicole Körber and Vuk Savkovic, both of the “Translationszentrum für Regenerative Medizin“ of the Universität Leipzig.

For the first time biosaxony e. V. awarded the best Bachelor’s and Master’s theses that students from Saxony had written in the subject of biotechnology. Claudia Heber was awarded the best Bachelor’s thesis  (conducted at „Berufsakademie Riesa“ and „Deutsche Biomasse Forschungszentrum Leipzig“). The second award was given to Helene Henning (B CUBE – Center for Molecular Bioengineering) and the third to Benedikt Schwarze (Universität Leipzig). Catleen Conrad (TU Bergakademie Freiberg) received the award for the best Master’s thesis in Saxony, followed by Tom Kunschmann (Universität Leipzig), and Sebastian Salentin (BIOTEC).

Photo: 29 Saxon industry exhibitors showed their products and technological applications in the foyer of the CRTD.  ©BIOTEC

„Sächsischer Biotechnologietag 2014“ – Converting Basic Research to Commercial Applications


The “Sächsische Biotechnologietag 2014” (Saxon Biotechnology Day 2014) presents itself as a competitive exhibition of Saxon biotechnology in research, economics, and commercial applications on March 19th, 2014. It  is organized by the Biotechnology Center of the TU Dresden (BIOTEC) and the  “Biotechnologisch-Biomedizinischen-Zentrum der Universität Leipzig” (BBZ) with the assistance of biosaxony e. V.

In 2014,  the “Sächsische Biotechnologietag as a Saxon wide forum will play a key role as communication and cooperation platform among researchers, enterprises, and technology transfer centers in Saxony . The realigned program  covers the first steps of a researcher for commercializing his research results to the point of the presentation of successfully established internationally acting enterprises. The main topics are „How to start and grow a business“, „Drug Discovery“, and „Sequencing“. More than 200 researchers and entrepreneurs from Saxony, Germany, and abroad are expected. This forum is framed by a competitive exhibition of Saxon biotechnology enterprises.

German Press Release

PROMOS Scholarship for BIOTEC and CRTD Masterstudents


Two students of the master’s programs of the Biotechnology Center of the TU Dresden (BIOTEC) and DFG-Research Center for Regenerative Therapies Dresden – Cluster of Excellence at the TU Dresden (CRTD) are awarded with a PROMOS scholarship of 300 Euros per month as a support for their 6-months stay at a US institution for their master’s thesis.  PROMOS is a scholarship program from the German Academic Exchange Service (DAAD) that supports short stay abroad of maximum 6 months so as to increase the mobility of German students. It is awarded on basis of academic excellence, motivation and relevance of the project.

Elisabeth Brandl, student in the CRTD master’s program “Regenerative Biology and Medicine” will do her thesis at the Diabetes Center of University of California in the group of Matthias Hebrok. Christian Winkler, student in the BIOTEC master’s program” Molecular Bioengineering”, will conduct his master’s thesis at the Fraunhofer Institute in Boston in the group of Alexis Sauer-Budge on Nanoscale Proteomics.

Photo: The Masterstudents Christian Winkler and Elisabeth Brandl are awarded with a PROMOS scholarship for their stay at a US institution for their master’s thesis.©BIOTEC/CRTD

Nikos Kyritsis receives “PhD Student Award in Regenerative Medicine”


The “Best Publication Award” by the Berlin-Brandenburg School for Regenerative Therapies (BSRT) was awarded to Dr. Nikos Kyritsis from the research group of Professor Michael Brand at the DFG Research Center for Regenerative Therapies Dresden - Cluster of Excellence (CRTD) at the TU Dresden.  The prize is given once a year by BSRT for excellent publications which promote the research on regenerative therapies. From the 15 submitted publications the independent jury had voted for Kyritsis paper „Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain “ which was  published in November 2012 in the journal Science (Science 2012, DOI 10.1126.science.1228773).

Injuries in the human brain and spinal cord cause an inflammatory response. Since decades it is discussed in medicine, if this reaction of the immune system after injuries of the central nervous system is rather promoting or inhibiting the healing process. For the first time, Dr. Nikos Kyritsis has demonstrated, using zebrafish as a model, that the inflammatory reaction is necessary for the regeneration of neuronal cells upon brain injury. In addition, they identified an inflammatory mechanism, which is regulating the activation of neural stem cell upon injury and leads to brain regeneration. The brains of humans and zebrafish might be different regarding size and appearance however they are evolutionarily related in terms of Neuroanatomy and Genetics, making zebrafish a great model to study acute central nervous system injuries and neurodegenerative diseases. Further information

Photo: Dr. Nikos Kyritsis ©CRTD

DFG further funds lipid research in Dresden, Heidelberg und Bonn


The German Research Association (DFG) extends the funding of the collaborative research center / Transregio (SFB/TTR 83) “Molecular Architecture and Cellular Functions of Lipid/Protein Assemblies”, a network of lipid research at the universities in Dresden, Heidelberg and Bonn, for another four years. Speaker University is the University of Heidelberg. In Dresden, the SFB/TRR83 is located at the BIOTEC with Professor Bernard Hoflack as regional speaker. The DFG granted from 2014 to 2017 funds of 6,9 million Euros. Dresden receives more than 2 million Euros for lipid research from this funding. The SFB/TRR83 was initially funded from January 2010 on for four years with 8,66 million Euros.

German Press Release.

Professorship for Biophysics at the BIOTEC was newly appointed


Stephan Grill has accepted the professorship for biophysics at the Biotechnology Center of the TU Dresden (BIOTEC). Before he was groupleader in Dresden at the Max Planck Institute of Molecular Cell Biology and Genetic as well as at the Max Planck Institute for Physics of Complex Systems. Particularly he is interested in molecular machines, their functions in cells as well as the responsible interaction among each other that constitute living organisms.

Photo: Professor Stephan Grill is a new groupleader at the BIOTEC. ©BIOTEC

British Ambassador is visiting the CRTD


Simon McDonald CMG, British Ambassador in Berlin, and Kenan Poleo, Regional Director UK Science and Innovation Network - Europe, Russia and Turkey, visited the DFG Research Center for Regenerative Therapies Dresden – Cluster of Excellence at the TU Dresden (CRTD) during their stay in Dresden. Professor Elly Tanaka (CRTD) and Professor Jochen Guck from the Biotechnology Center of the TU Dresden presented the research areas of both institutes. In particular they were interested in the regeneration research on Axolotl of Professor Elly Tanaka.

In the evening, the British Ambassador started the lecture series “Wissensbrücken” of the TU Dresden with his talk „Creating Prosperity – is research expensive theory or driver for growth?”. The lecture series records different aspects of the synergetic university and will reveal approaches for the complex challenges of the 21th century in the dialogue between science, economy, culture and politics.

Picture: Professor Elly Tanaka explained the British Ambassador in Germany, Simon McDonald, the regeneration of Axolotls.©CRTD

Mayor of Dresden received international scientists


450 international guests visited the reception of the Dresden Mayor Helma Orosz at the State Museum Albertinum on September 12th, 2013, including scientist of the DFG Research Center for Regenerative Therapies Dresden – Cluster of Excellence (CRTD), the Biotechnology Center of the TU Dresden (BIOTEC), and the Center for Molecular Bioengineering (B CUBE). This year the event was themed “Welcome Culture”. To the reception invited were people, who came to Dresden from abroad and live  here permanently or temporarily for professional reasons. After the special concert of the Dresden Philharmonic Orchestra there was time for exchange between the scientists and the Mayor.

Picture: The Dresden Mayor (in the middle) with scientists from the CRTD and BIOTEC ©:Stadt Dresden/ Matthias Rietschel

New day care places for CRTD and BIOTEC employees


Employees of the DFG Center for Regenerative Therapies Dresden (CRTD) and the Biotechnology Center of the TU Dresden (BIOTEC) can look forward to more day care places for their children. Today, the part of the day care for kids until 3 years of age is opening on Loschwitzer Straße 21. On August 1st, the day care part for kids from age 3 will open. There are 21 places reserved for children of employees of the CRTD and the BIOTEC. Next to the Kita Biopolis, which opened in 2009, this is the second day care with reserved spots for BIOTEC and CRTD employees. The Thüringer Sozialakademie is operating the day care center on Loschwitzer Straße as well as the Biopolis one. The new day care is located in the Villa St. Petersburg that was built in 1872 in the style of historism. In 1995, the villa was renovated and used most recently by the Institut für Bildung und Beratung. After a further renovation and reconstruction the villa can now be used as day care.

Photo: Day care on Loschwitzer Straße 21. ©CRTD

Work against Poverty at the „Day of Action genialsozial 2013” – Pupils work at the BIOTEC


During the Saxon „Day of Action genialsozial 2013” on July 9, 2013 pupils can exchange a day in school for a day at work in companies, associations, or institutes. Their wages are afterwards donated to humanitarian or social projects. Today there are two pupils, grade 5 and 7 from two different grammar schools, working in the Biotechnology Center at the TU Dresden in the office of the administration and in the media kitchen that prepares solutions and culture media for the scientific work. This year, the BIOTEC is participating for the first time in this initiative of the Saxon Youth Foundation. One part of the wages this year will benefit the flood aid. In addition, projects of the development cooperation in Guatemala, Mozambique, and Madagascar are supported.

Website of the initiative:  http://www.genialsozial.de

Summer Party at the Kita Biopolis


For the children of the Kita Biopolis who celebrated their summer party with families and friends in magnificent summer weather, the water slide was an ideal cooling. One highlight was the participatory circus, which was sponsored by the “Friends of the Day Care Centre Biopolis e.V.”: The children practiced how to juggle, jumped over imaginary fire like lions, or performed little tricks as waddling penguins. The girls from the dancing project “Tanzmäuse” had practiced two dances, which they performed with umbrellas and scarfs.
The Kindergarten Biopolis is a joint facility of the Thüringer Sozialakademie, the DFG Research Center for Regenerative Therapies Dresden – Cluster of Excellence at the TU Dresden, the Biotechnology Center of the TU Dresden, and the Max Planck Institute for Molecular Cell Biology and Genetics.

Photo: Dancing Girls of the Kita Biopolis. ©Privat

Axolotl, Bananas, and Genes: More than 1,600 Visitors came into the CRTD during the Long Night of Science


Which organism has the most genes? Answers to these and other fascinating questions were given to more than 1,600 visitors at the CRTD during the 11th Long Night of Sciences. Scientists of the DFG Research Center for Regenerative Therapies – Cluster of Excellence (CRTD), the Biotechnology Center of the TU Dresden (BIOTEC), the ZIK BCUBE, the Paul Langerhans Institute (PLID), the German Center for Neurodegenerative Diseases (DZNE), and the Medical Faculty Carl Gustav Carus presented their research on July 5th, 2013 from 6pm – 1 am: At various stations, lectures, and children tours it was possible for anyone to get an insight into the work of the CRTD and other institutes in the network. The visitors were able to extract DNA from bananas together with international students of the School Project, they learned more about the regenerative capacity of Axolotls and zebrafish as well as about forces in the cell or latest diabetes and neurodegenerative research. By the way: Plants like horse tail or tulips possess more genes than mammalians like the human being.

We want to say "Thank you" to all the scientists for their contributions to this successful long night of science. They made this diverse program possible.
The next Dresden Science Night will be on July 4th, 2014.

Photo: Examining the samples under a microscope for children. ©CRTD

From Basic Research to Therapeutic Application. Saxony funds five translation projects of the BIOTEC and CRTD


Four research projects of the Biotechnology Center of the TU Dresden (BIOTEC) and one project of the DFG Research Center for Regenerative Therapies Dresden – Cluster of Excellence of the TU Dresden (CRTD) receive a funding by the Saxon Ministry of Science and Fine Arts (SMWK). The aid money is provided by the Free State of Saxony in the "Offensive Biotechnology and Life Sciences 2020" for sustaining the available future potential of the region, which was " launched end of 2012.In the next two years there will be nine million Euros invested in the key technologies biotechnology and life sciences.  Out of 144 applications submitted from Saxony, 26 projects were chosen for funding with the goal of research and their economical application (translation).

See German Press Release

Interior Design for Stem Cells


How are stem cells influenced by their environment? For a better understanding of this question, scientists of the Leibniz-Institut für Polymerforschung Dresden, the Medical Faculty of the TU Dresden and the DFG Research Center for Regenerative Therapies Dresden have reproduced the micro environment of stem cells in the laboratory. They have developed a matrix structure in which human blood stem cells grow three times faster than with previous conditions. These results were published June 16th in the journal Nature Method (http://dx.doi.org/10.1038/nmeth.2523).

Axolotl, new Neural Stem Cells, and DNA from Bananas


Long Night of Science: Discover Science and experiment

What are genes made of? How many genes has a human being? These exciting questions will be answered by scientists in the DFG Research Center for Regenerative Therapies Dresden – Cluster of Excellence at the TU Dresden (CRTD), Fetscherstraße 105, 01307 Dresden during the Long Night of Science on Friday, July 5th, 2013 from 6pm to 1am.  Research groups of the CRTD, the Biotechnology Center of the TU Dresden (BIOTEC), the Center for Innovation BCUBE, the Paul Langerhans Institute Dresden (PLID), the German Center for Neurodegenerative Diseases (DZNE), as well as the Medical Faculty Carl Gustav Carus will offer a look over their shoulder, will give talks and invite visitors to actively participate in experiments.  For children there will be extra tours to the Axolotl. International student teams and students of the CRTD cooperation school Martin-Andersen-Nexö-Gymnasium will show experiments.

German Press Release

Website Long Night of Science 2013



Natural Scientists and Humanists acquire information together


Creating interdisciplinary dynamic is the goal of 40 genetics, chemists, and historians who will meet at the workshop “Transmission of Information in the time and in space in the Dresden Bioinnovation Center from June 16th to 18th, 2013. This multidisciplinary international symposium on acquirement of information takes place for the first time and  is organized by the Biotechnology Center of the TU Dresden (BIOTEC), the Center for Innovation “Center for Molecular Bioengineering“ (ZIK BCUBE), and the Research Centre for the Comparative History of Religious Orders (FOVOG) at the TU Dresden.

German Press Release

Website of the Workshop

Twelve million euros for Dresden SBF 655 „ Cells into tissues“


German Research Foundation funds Dresden cutting-edge research for another four years

The third period of the Collaborative Research Center (Sonderforschungsbereich) SFB 655 "From cells to tissues - commitment and interaction of stem cells and progenitor cells during tissue formation" will start on 1 July 2013. After the continued application of the Technical University had been successfully evaluated in mid-March 2013 in Dresden, now the Grants Committee of the German Research Foundation DFG in Bonn approved funding for another four years. For this period, the SFB 655 will receive about twelve million euros. German Press Release

A real-time view onto the rules of life


Naturally occurring bacteria and viruses are in a constant struggle for existence among each other. Bacteria developed a kind of immune system in order to protect themselves from virus attacks: Special defense enzymes can destroy the viral genetic information (DNA) and at the same time assure that the DNA of the bacterium isn’t attacked. In this process involved are markers on the DNA of the bacteria that are missing in the viruses. Physicists of the Biotechnology Center of the TU Dresden (BIOTEC) were examining in cooperation with scientists from the University of Bristol, how the defense enzymes scan the bacteria DNA for these markers and how they communicate between them in order to start the defense mechanism. They were able to observe for the first time in real-time how the defense enzymes move by means of thermic energy very efficiently between two markers that are located far apart in the genome. The results of this study were published in the magazine Science. 

See German Press Release


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