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PhD student (E 13 TV-L)


At DFG-Center for Regenerative Therapies Dresden the Chair of Molecular and Cellular Immunology / Focus Immune Regulation (Prof. Dr. Karsten Kretschmer) offers a position as

PhD student (E 13 TV-L)

starting September 1st 2014 which entail 50 % to 65 % of the fulltime weekly hours. We initially offer a contract for three years. The period of employment is governed by the Fixed Term Research Contracts Act (Wissenschaftszeitvertragsgesetz - WissZeitVG). The research interest of our group focuses on molecular and cellular pathways that govern the generation, lifestyle and function of Foxp3+ regulatory T (Treg) cells, which play an essential role in maintaining immune homeostasis in mice and men. A particularly striking example of Foxp3+ Treg cell function that restrains destructive tissue-specific autoimmunity is our recent observation that acute Treg cell ablation in the NOD mouse model of human type 1 diabetes unleashes overt autoimmune diabetes within days (Petzold et al., J Diabetes Res 2013). Conversely, Treg cells represent exciting gain-of-function targets in clinical settings of unwanted immune responses, such as autoimmunity, allergies and transplant rejection.

Position and Requirements

The PhD position we offer is part of a project in which we aim to investigate the molecular and epigenetic mechanisms underlying the development of Foxp3+ Treg cell sublineages. In this context, a particular focus is placed on exploring the possibility that different Treg cell subphenotypes exert specialized effector functions in the control of unwanted immunity, such as organ-specific autoimmunity (webpage:  http://www.crt-dresden.de/research/crtdcore-groups/kretschmer.html).
We aim at attracting the best talent in the respective research fields and expect the following: an outstanding masters university degree (or equivalent) in Biology, Science or related field of science; experience in  immunology, flow cytometry, gene-targeted and autoimmune mouse models, cell culture and molecular/biochemical methods; ability to work
in an international team is essential; inter- and multidisciplinary thinking; high motivation; an integrative and cooperative personality with excellent communication and social skills; fluency in English – written and oral.
Applications from women are particularly welcome. The same applies to people with disabilities.

Application Procedure

Your application should include: Cover letter, indicating current and future research interests and career goals;  description of research experience and accomplishments, including summary of previous research done during your master thesis (max. 2 pages);  list of
publications, if available; CV, including copies of degree certificates and transcript of grades (i.e. the official list of coursework including your grades); two letters of recommendation or contact information for two references, including current supervisor.
Please submit your application by 8th August 2014 (stamped arrival date applies) preferably by email as a single pdf document (using “surname_firstname.pdf”) to: silvia.palme(at)tudresden.de (Please note: We are currently not able to receive electronically signed and encrypted data.) or via central mail service to the following address: TU Dresden, CRTD, Frau Silvia Palme, Fetscherstr. 105, 01307 Dresden, Germany.



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