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The Interface of Hormonal and Neuronal Signals in the Regulation of Bone Remodelling // A Sticky Situation: Unraveling the mechanism of diatom adhesion and motility

CMCB PhD/Postdoc seminar

Date:23.03.2018, 16:00 - 17:00
Speaker: Holger Henneicke, Manuel Gado (Predoc) // Nils Kröger, Nicole Poulsen (Postdoc)
Location: CRTD, auditorium left

Abstract (Holger Henneicke, Manuel Gado)

The skeleton undergoes constant renewal throughout life - a process referred to as bone remodelling. Failure of this process leads to a decline in bone quality and ultimately causes osteoporotic fractures. Hormonal signals, including stress hormones, as well as the central nervous system are powerful regulators of bone remodelling. Here we aim to investigate the intersection of hormonal as well as neuronal signals in regulating the renewal of the skeleton. Ultimately this research will inform therapies supporting the healthy maintenance of the skeleton throughout life.

Abstract (Nils Kröger, Nicole Poulsen)

Diatoms and bacteria are the dominant taxa in marine biofilm communities that colonize every biotic or abiotic surface in sunlit marine environments. The accumulation of biofilms on ship hulls poses significant problems due to enhanced drag and consequently increased fuel consumption. To develop coatings that prevent the accumulation of diatom biofilms, a better understanding of the molecular mechanism of diatom adhesion is required. Diatoms are a large group unicellular algae that are responsible for ~20% of the global primary biomass production and possess intricate cell walls made of nanopatterned silica. The underwater adhesion of diatoms is accomplished through the secretion of carbohydrate-rich extracellular polymeric substances (EPS). So far, the molecular composition of the diatom adhesive trails has remained poorly characterized. Here we report our results from the proteomics analysis of diatom adhesive trails and provide the insight into the mechanism of the diatom adhesion and motility.

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