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Evolution of transcription factor networks in primate brains

CMCB Green Seminar

Date:24.10.2018, 11:00 - 12:00
Speaker: Katja Nowick, Freie Universität Berlin
Location: CRTD, auditorium left
Host: Dr. Volker Busskamp

Abstract
Our group studies the evolution of primates. We are interested in the molecular forces that shape phenotypic differences between primate species. I am most fascinated by the differences in brain size and cognitive abilities. Our main focus is on the impact of Gene regulatory factors, such as transcription factors and non-coding RNAs, on differences in transcriptomes, gene regulatory networks, and ultimately the phenotype. We use computational and wet-lab methods to understand the evolution of human specific phenotypes.

5 most recent papers
Kutsche, L.K., Gysi, D.M.*, Fallmann, J., Lenk, K., Petri, R., Swiersy, A., Klapper, S.D., Pircs, K., Khattak, S., Stadler, P.F., Jakobsson, J., Nowick, K. and Busskamp, V. (2018) Combined experimental and system-level analyses reveal the complex regulatory network of miR-124 during human neurogenesis, Cell Systems in press (*my PhD student is shared first author)

Berto, S. and Nowick, K. (2018) Species-specific changes in a primate transcription factor network provide insights into the molecular evolution of the primate prefrontal cortex, Genome Biology and Evolution 2018 Jul 30. doi: 10.1093/gbe/evy149

Berto, S., Perdomo-Sabogal, A., Gerighausen, D., Qin, J., Nowick, K. (2016) A transcription factor consensus network of the human frontal lobe: insights into the molecular mechanisms of human cognitive abilities, Frontiers in Genetics: Special on Systems biology of transcriptional regulation

Perdomo-Sabogal, A., Nowick, K.*, Piccini, I., Sudbrak, R., Lehrach, H., Yaspo, ML., Warnatz, HJ.†, Querfurth, R.*† (2016) Human lineage-specific transcriptional regulation through GA binding protein transcription factor alpha (GABPa), Molecular Biology and Evolution 2016 May; 33(5):1231-44. doi: 10.1093/molbev/msw007 (*shared corresponding author)

Perdomo-Sabogal, A., Kanton, S., Walter, M.B.C., Nowick, K. (2014) The roles of gene regulatory factors in the history of human evolution, Current Opinion in Genetics and Development 9;29C: 60-67

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