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Building cortical networks: from molecules to function

CMCB Life Sciences Seminar

Date:16.05.2019, 16:00 - 17:00
Speaker: Prof. Beatriz Rico, King's College London
Location: CRTD, auditorium
Host: Dr. Madalena Carido (CRTD/DZNE)

Understanding brain function and dysfunction begins with the knowledge of how neuronal connections are established and organised in functional networks. To address this question my lab is focused in three main questions: 1) How are the mammalian cortical networks built, 2) how do they respond to activity and, 3) What are the functional consequences of disrupting the development of cortical circuitries.

Most important publications
1.-Favuzzi E*, Deogracias R*, Marques-Smith A, Maeso P, Exposito-Alonso D, Kroon T., Baglia M., Fernandez- Maraver E, Rico B (2019). Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits, Science 363: 413-417.

2.-Hinojosa, A.J., Deogracias, R., Rico, B (2018). The microtubule regulator Nek7 coordinates the wiring of cortical Parvalbumin interneurons. Cell Reports 24:1231-1242.

3.-Favuzzi I, Marques-Smith A, Deogracias R, Winterflood CM, Mantoan L, Fernandes C, Ewers H & Rico B (2017). Activiy-dependent gating of Parvalbumin interneuron function by perineuronal nets, Neuron 95: 639-655.

4.-Del Pino I, Brotóns-Más J, Marques-Smith A, Marighetto A, Frick A, Marín O*, Rico B* (2017). Abnormal wiring of CCK+ basket cells disrupts spatial information coding, Nature Neuroscience, 20:784-792.

5.-Del Pino I, Garcia-Frigola C, Dehorter N, Brotons-Mas JR, Alvarez-Salvado E, Martinez De Lagran M, Ciceri G, Gabaldon MV, Moratal D, Dierssen M, Canals S, Marín O*, Rico B* (2013) Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes. Neuron 79:1152-1168.

6.-Fazzari P, Paternain AV, Valiente M, Pla R, Luján R, Lloyd K, Lerma J, Marín O*, Rico B* (2010) Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature 464:1377-1380.

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