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CNS Scarring and Repair

CMCB Life Sciences Seminar

Date:06.06.2019, 16:00 - 17:00
Speaker: Prof. Christian Göritz, Karolinska Institutet Stockholm, Department of Cell and Molecular Biology
Location: CRTD, ground floor, auditorium left
Host: Dr. Olaf Bergmann

Damage to the mammalian central nervous system often leads to persistent functional deficits. One important cause why these deficits become permanent is the establishment of a scar that blocks regeneration. This seminar will explore the questions of (1.) what the origin and function of scar tissue is and (2.) how different scar components influence axonal regeneration and functional recovery after CNS injury. Evidence will be presented that (1.) a specific subpopulation of perivascular cells is the main source of stromal scartissue following spinal cord injury. (2.) Pericyte-derived fibrotic cells participate in the wound closure and are crucial for the re-establishment of tissue integrity after injury but constitute the long-term persistent fibrotic scar core. (3.) Attenuation of pericyte-derived scarring improves axonal regeneration and functional recovery. (4.) Pericytes as a new therapeutic target for the treatment of CNS injury.

Selected publications:
* Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth. Reichenbach B, Classon J, Aida T, Tanaka K, Genander M, Göritz C. EMBO J. 2018 May 2;37(9). pii: e98280.

* Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. Dias DO, Kim H, Holl D, Werne Solnestam B, Lundeberg J, Carlén M, Göritz C*, Frisén J. Cell. 2018 Mar 22;173(1):153-165.e22. *Lead contact author

* A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse. Magnusson JP*, Göritz C*, Tatarishvili J, Dias DO, Smith EM, Lindvall O, Kokaia Z, Frisén J. Science. 2014 Oct 10;346(6206):237-41. *Equal contribution

* Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice. Sabelström H, Stenudd M, Réu P, Dias DO, Elfineh M, Zdunek S, Damberg P, Göritz C & Frisén J. Science. 2013 Nov 1;342(6158):637-40.

* A pericyte origin of spinal cord scar tissue. Göritz C, Dias DO, Tomilin N, Barbacid M, Shupliakov O, Frisén J. Science. 2011 Jul 8;333(6039):238-42.

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