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Precise genome engineering to empower drug discovery

BIOTEC Seminar

Date:18.01.2019, 15:00 - 16:00
Speaker: Marcello Maresca, AstraZeneca Research Gothenburg, Sweden
Location: CRTD, auditorium left
Host: Prof. Dr. Francis Stewart


Gene and base editing hold great promises in the prevention and treatment of genetic diseases. Predicting the on-target and off-target activities of Cas9/CRISPR and Base Editors is an essential requirement for a safe and efficacious treatment. Recent progress shows how the analysis and modulation of DNA repair pathway can be applied to predict base and genome editing outcomes.

  • Taheri-Ghahfarokhi, Amir, et al. "Decoding non-random mutational signatures at Cas9 targeted sites." Nucleic acids research 46.16 (2018): 8417-8434.
  • Akcakaya, Pinar, et al. "In vivo CRISPR editing with no detectable genome-wide off-target mutations." Nature 561.7723 (2018): 416.
  • Wienert, Beeke, et al. "Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq." bioRxiv (2018): 469635.

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