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POSTPONED: Molecular, mechanical, and cellular mechanisms of fibrosis

CMCB Life Sciences Seminar

Date:19.03.2020, 13:00 - 14:00
Speaker: Boris Hinz, University of Toronto
Location: CRTD, ground floor, auditorium left
Host: Elisabeth Fischer-Friedrich

 

5 most important publications:


Hinz, B. and Lagares, D., (2020) Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases. Nature Reviews Rheumatology 16(1):11-31

Pakshir, P., Alizadehgiashi, M., Wong, B., Coelho, N.M., Chen, X., Gong, Z., Shenoy, V.B., McCulloch, C., and Hinz, B. (2019): Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix. Nature Communications 10: 1850

Li, C.X., Talele, N.P., Boo, S., Knee-Walden, E., Koehler, A., Kapus, A., Speight, P., Balestrini, J.L., Hinz, B. (2017). Micro RNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells. Nature Materials 16(3):379-389

Klingberg, F., Chow, M. L., Koehler, A., Boo, S., Buscemi, L., Quinn, T. M., Costell, M., Alman, B. A., Genot, E., and Hinz, B. (2014). Prestress in the extracellular matrix sensitizes latent TGF-beta1 for activation. J Cell Biol 207, 283-297

Buscemi, L., Ramonet, D., Klingberg, F., Formey, A., Smith-Clerc, J., Meister, J.-J., and Hinz, B.: (2011) The single-molecule mechanics of the latent TGFβ1 complex. Current Biology 21, 2046–2054

Abstract:

To rapidly restore mechanical integrity of tissues after injury, a variety of different cell types are activated to become myofibroblasts. Hallmarks of the myofibroblast are secretion of extracellular matrix (ECM), development of adhesion structures with the ECM, and formation of contractile stress fiber bundles. When contracture and ECM remodeling become progressive and manifest as organ fibrosis, stiff scar tissue obstructs and ultimately destroys organ function. Pivotal for the formation and persistence of myofibroblasts are mechanical stimuli arising during tissue repair and chronic persistence of inflammatory cells. I will give an overview on our current projects that address how mechanical factors orchestrate the development of myofibroblasts by mediating direct and far/ranging communication between myofibroblasts and macrophages. By understanding and manipulating myofibroblast and macrophage mechanoperception we will be able to devise better therapies to reduce scarring and support normal wound healing.

Everybody is welcome!

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