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Assembly of functional visual circuits: roles for adhesion molecules and neuronal morphology

CMCB Green Seminar

Date:11.10.2018, 16:00 - 17:00
Speaker: Dr. Robert Hindges, King’s College London, Centre for Developmental Neurobiology & MRC Centre for Neurodevelopmental Disorders
Location: CRTD, ground floor, auditorium left
Host: Dr. Madalena Carido Pereira

Abstract
A fundamental issue during brain development is the correct formation of connections. Accuracy of these events is critical for the correct function of the brain, including processes involved in memory, learning, perception and behaviour. My lab is interested in the molecular mechanisms underlying the assembly of the vertebrate visual circuitry. Our research mainly focuses on genes controlling synapse specificity between different subpopulations of retinal neurons, as well as long-range connections between the eye and retinorecipient areas. In addition, we are interested in how specific dendritic structures of retinal neurons generate visual functionalities.

5 most recent papers
Antinucci, P., Suleyman, O., Monfries, C. & Hindges, R. (2016). Neural Mechanisms Generating Orientation Selectivity in the Retina. Current Biology 26: 1802-1815.

Antinucci, P., Nikolaou, N., Meyer, M.P. & Hindges, R. (2013). Teneurin-3 specifies morphological and functional connectivity of retinal ganglion cells in the vertebrate visual system. Cell Reports 5: 582-592.

Maiorano N.A. & Hindges, R. (2013) Restricted perinatal retinal degeneration induces retina reshaping and correlated structural rearrangement of the retinotopic map, Nature Commun. 4:1938 doi: 10.1038/ncomms2926 (2013).

Pinter, R. & Hindges, R. (2010). Perturbations of MicroRNA Function in Mouse Dicer Mutants Produce Retinal Defects and Lead to Aberrant Axon Pathfinding at the Optic Chiasm, PLoS ONE 5(4): e10021.

Hindges, R., McLaughlin, T., Genoud, N., Henkemeyer, M. & O'Leary, D.D.M. (2002). EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping. Neuron 35: 475-487.

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