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“M-CSF induced myeloid/NK cell differentiation cascade protects against CMV viremia post-HSCT” & “Myeloid control of immune checkpoint inhibition in colorectal cancer”

CMCB Postdoc Seminar

Date:07.02.2020, 16:00 - 17:00
Speaker: Michael Sieweke, Kandalla Prashanth Kumar & Sebastian Zeißig, Kenneth Peuker
Location: CRTD, auditorium left

 

Abstract (Michael Sieweke, Kandalla Prashanth Kumar):

Immune suppressed patients with leukopenia are highly susceptible to viral infections such as Cytomegalovirus (CMV), a**major cause of post hematopoietic stem cell transplantation (HSCT) morbidity and mortality. Immuno-therapies that could reconstitute anti-viral immune competence have not been identified so far. Here we show that M-CSF/CSF-1, a key cytokine of myelo-monocytic differentiation, surprisingly promoted rapid reconstitution of antiviral activity and protection from MCMV viremia in a mouse model of HSCT by stimulating NK cell differentiation and activation.

Abstract (Sebastian Zeißig, Kenneth Peuker):

Immune checkpoint inhibition has revolutionized the treatment of selected cancer entities, but has largely failed to demonstrate efficacy in some of the most common malignancies including colorectal cancer (CRC). The mechanisms of failure of checkpoint inhibition in CRC, however, are poorly understood. In this seminar, we will discuss the identification of a novel network of crosstalk between myeloid tumor-infiltrating cells, T cells and epithelial tumor cells, which promotes intestinal tumor development and metastasis through inhibition of cytotoxic T cell responses. We will discuss how barrier dysfunction and microbial translocation into tumors elicits cytokine responses by tumor-infiltrating myeloid cells, which in turn promote the expression of co-inhibitory proteins by the tumor epithelium to inhibit cytotoxic T cell responses. Finally, we will show that interference with this pathway in mice results in the activation of anti-tumor immunity, regression of established metastatic disease and durable disease control.

 ... followed by social hour! Everybody is welcome!

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