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Eye tissue Regeneration at the Molecular Age

CMCB external seminar

Date:30.05.2018, 14:00 - 15:00
Speaker: Prof. Katia Del Rio-Tsonis, Miami University,
Oxford, OH
Location: CRTD, ground floor, auditorium left
Host: Prof. Michael Brand (CRTD)


Several animals have the ability to regenerate parts of their eye if damaged or removed. Salamanders can regenerate their lenses completely and functionally at any stage of their lifetime by reprogramming pigmented cells of their iris. On the other hand, embryonic chicks can regenerate their retinas if removed by reprogramming retina pigmented epithelial cells. We are dissecting the molecular mechanisms involved in the reprogramming process in both model organisms and moving forward to apply this information towards human iPSC modeling systems. Our work will contribute important information that can help develop therapies for the many blinding diseases that currently rip the sight of many people around the world.

Recent Publications:

Haynes T, Luz-Madrigal A, Reis ES, Echeverri Ruiz NP, Grajales-Esquivel E, Tzekou A, Tsonis PA, Lambris JD, Del Rio-Tsonis K. Complement anaphylatoxin C3a is a Potent Inducer of Embryonic Chick Retina Regeneration. Nat Commun. 4: 2312, 2013.

Suetsugu-Maki R, Maki N, Nakamura K, Sumanas S, Zhu J, Del Rio-Tsonis K and Tsonis PA. Lens regeneration in axolotl: new evidence of developmental plasticity. BMC Biology 10(1):103, 2012.

Tsonis PA, Haynes T, Maki N, Casco-Robles MM, Yamada S, Miura T, Chiba C and Del Rio-Tsonis K. Controlling gene loss of function in newts with emphasis on lens regeneration. Nature Protocols 6(5): 593-9, 2011.

Vergara MN and Del Rio-Tsonis K. Retinal regeneration in the Xenopus laevis tadpole: a new model system. Mol. Vis. 15:1000-10013, 2009.

Haynes, T, Gutierrez, C, Aycinena, JC, Tsonis, PA and Del Rio-Tsonis, K. BMP signaling mediates stem/progenitor cell induced neural retina regeneration. PNAS 104(51):20380-5, 2007.

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