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Controlling human islet formation

External Diabetes Research Seminar

Date:05.06.2018, 15:30 - 16:30
Speaker: Matthias Hebrok, UCSF Diabetes Center
Location: CRTD, Auditorium left

Dr. Hebrok's work focuses on understanding the mechanisms underlying pancreas development and disease, including Diabetes and Pancreatic cancer. His research on the role of embryonic signaling pathways in these processes has provided a glimpse into how tight regulation of these signaling events is imperative for proper organogenesis and formation of functional beta cells. His lab has used the information gained from these developmental studies to understand processes underlying the dedifferentiation and dysfunction of pancreatic beta cells. In addition, his group has been optimizing differentiation conditions to generate functional beta cells from human embryonic stem cells and converted fibroblasts. The goal of his studies is to study human beta cell biology with the intent of preventing or reversing defective processes that occur during the development and progression of diabetes.

5 selected publications:

1. Thayer*, S. P., Pasca di Magliano, M., Heiser, P.W., Roberts, D. J., Nielsen, C. M., Lauwers, G. Y., Qi, Y.P., Gysin, S., Fernandez-del Castillo, F., Yajnik, V., Antoniu, B., McMahon, M., Warshaw, A. L., and M. Hebrok* (2003): Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425, 851 - 856. * Co-corresponding authors. PMC3688051

2. Puri, S., Akiyama, H., and M. Hebrok (2013): VHL-mediated disruption of Sox9 activity compromises ß-cell Identity and Results in Diabetes.Genes & Development. 2013 Dec 1;27(23):2563-75. doi: 10.1101/gad.227785.113. PCMID: PMC3861670.

3. von Figura, G., Fukuda, A., Liku. M. E., Morris, J. P., Kim, G. E., Russ, H. A., Firpo, M. A., Mulvihill, S., Mueller, W. F., Busch, A., Hertel, K. J., and M. Hebrok (2013): Loss of Brg1 Cooperates with Oncogenic Kras to Form Intraductal Papillary Mucinous Neoplasm and Pancreatic Ductal Adenocarcinoma. Nature Cell Biology, 2014 Mar;16(3):255-67. doi: 10.1038/ncb2916. Epub 2014 Feb 23. PMC4684081.

4. Russ, H. A., Parent, A. V., Ringler, J. J., Hennings, T. G., Nair, G. G., Shveygert, M., Guo, G., Puri, S., Haataja, L., Cirulli, V., Szot, G., Arvan, P. and M. Hebrok (2015): Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro. Embo J.,2015 Apr 23. pii: e201591058. PMCID: PMC4516429

5. Zhu, S., Russ, H. A., Wang, W., Hebrok*, M., and S. Ding* (2016): Direct conversion of human fibroblasts into endodermal progenitors giving rise to functional beta-like cells. Nature Communications, 2016 Jan 6;7:10080. doi: 10.1038/ncomms10080. PMCID: PMC4729817.*Co-corresponding authors.

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