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October 01 - October 31

8 entries found

Start date: October 02
11:00 am 12:00 pm


About the research of Dr. Grimpe: The research of my laboratory addresses spinal cord injury and the concomitant failure of nerve regeneration. As a possible new therapeutic we demonstrated the many desirable properties of deoxyribozymes, a knock down technology able to strongly reduce the expression of arbitrary proteinous inhibitors of axonal growth. Due to the multitude of involved interacting biomolecules my laboratory employed more and more sophisticated software tools in order to cope with complexity, predict regulation mechanisms and to identify promising molecular targets. Computer-based comparative analysis of regenerating and non-regenerating animals is forming one new direction of investigations. Through all that, my group became convinced that knowledge representations, computational modeling and simulation in combination with wet lab experiments will institute a new promising research strategy to overcome the barring complexity encountered in such notoriously hard problems like spinal cord injury and regeneration. Publications: Lemmon V, Ferguson A, Popovich P, Xu XM, Snow D, Igarashi M, Beattie C, Bixby J. Consortium: Abeyruwan S, Beattie M, Bethea J, Bradke F, Bresnahan J, Bunge M, Callahan A, David S, Dunlop S, Fawcett J, Fehlings M, Fischer I, Giger R, Goshima Y, Grimpe B, Hagg T, Hall E, Harrison B, Harvey A, He C, He Z, Hirata T, Hoke A, Hulsebosch, Hurtado A, Jain A et al. (2014) Minimal Information About a Spinal Cord Injury Experiment (MIASCI): a proposed reporting standard for spinal cord injury experiments, Journal of Neurotrauma, Epub ahead of print      (IF: 4.295)

Oudega M, Chao OY, Avison DL, Bronson RT, Buchser WJ, Hurtado A, Grimpe B (2012) Systemic administration of a deoxyribozyme to xylosyltransferase-1 mRNA promotes recovery after a spinal cord contusion injury, Experimental Neurology, 237: 170-179  (IF: 4.699)

Hurtado A, Podini H, Oudega M, Grimpe B (2008) Deoxyribozyme-mediated knock down of xylosyltransferase-1 mRNA promotes axon growth in the adult rat spinal cord, Brain 131: 2596-605  (IF: 9.457)    

Ries A, Goldberg JL, Grimpe B (2007) A novel biological function for CD44 in axon growth of retinal ganglion cells identified by a bioinformatics approach, Journal of Neurochemistry 103: 1491-1505  (IF: 4.061)

Grimpe B, Silver J (2004) A novel DNA-enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted DRG axons to regenerate beyond lesions in the spinal cord, Journal of Neuroscience 24: 1393-1397  (IF: 7.27)

Review: Grimpe B (2012) Deoxyribozymes and bioinformatics: Complementary tools to investigate axon regeneration. Cell Tissue Research, 349:181-200  (IF: 3.114)

Machine lea..
Start date: October 02
04:00 pm 05:00 pm


The Group Leader introduction will discuss how machine learning and complex-network science can play a crucial role in the new upcoming health-science revolution towards personalized and systems biomedicine. To this aim, the PhD student will present a new easy and fast unsupervised multivariate method for reveling discriminative network functional modules in omics (lipidomics, metabolomics, metagenomics, genomics, etc.) data. In particular, the key network role of the transcription factor gata6 in controlling the proliferation of carcinoma cancer cell will be discussed.

Start date: October 05
11:00 am 12:00 pm


About the research of Maksim Plikus:

My laboratory studies regeneration in adult mammals. We use skin as the primary research model. In the normal skin we study how hundreds of thousands of hair follicles coordinate their regeneration cycles with one another. We show that organ-level management of regeneration can be achieved via the self-organization mechanism based on the Cellular Automata principle. In the wounded skin we study how de novo regeneration can be reactivated. We show that new skin can regenerate via mechanisms that partially replicate embryonic development.

(1) Plikus MV, Mayer J, de la Cruz D, Baker R, Maini P, Maxson R, Chuong C (2008). Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature 451: 340-344 http://www.ncbi.nlm.nih.gov/pubmed/18202659

(2) Plikus MV, Baker R, Chen C, Fare C, de la Cruz D, Andl T, Maini P, Millar S, Widelitz R, Chuong C (2011). Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science. 332: 586-589. http://www.ncbi.nlm.nih.gov/pubmed/21527712

(3) Plikus MV, Vollmers C, De la Cruz D, Chaix A, Ramos R, Panda S, Chuong CM (2013) Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling. Proc Natl Acad Sci USA. 110: E2106–E2115. www.ncbi.nlm.nih.gov/pubmed/23690597

(4) Gay D, Kwon OS, Zhang Z, Burrows M, Plikus MV, Holler PD, Ito M, Yang Z, Treffeisen E, Kim CD, Nace A, Zhang X, Baratono S, Wang F, Ornitz DM, Millar SE, Cotsarelis G (2013). Fgf9 from dermal γδT cells induces hair follicle neogenesis after wounding. Nature Medicine. 19: 916-923. http://www.ncbi.nlm.nih.gov/pubmed/23727932

(5) c. Zhang LJ, Guerrero-Juarez CF, Hata T, Bapat SP, Ramos R, Plikus MV, Gallo RL (2015). Dermal adipocytes protect against invasive Staphylococcus aureus skin infection. Science 347: 67-71. http://www.ncbi.nlm.nih.gov/pubmed/25554785

Müller Cell..
Start date: October 09
11:00 am 12:00 pm


About the research of Andreas Bringmann: The topics of the research are the contribution of Müller cell gliosis to the development of retinal edema and neurodegeneration and functional alterations of the retinal pigment epithelium which may contribute to the development of AMD. Previous research involved studies regarding the functional roles of glial potassium and water channels in the normal and diseased retina, the mechanisms of cellular swelling and the receptor-mediated regulation of the Müller and neuronal cell volume, the role of purinergic receptors in the retinal development and under pathological conditions, and the functional roles of cytokines in the retinal pigment epithelium.


(1) Uckermann O, Vargová L, Ulbricht E, Klaus C, Weick M, Rillich K, Wiedemann P, Reichenbach A, Syková E, Bringmann A. Glutamate-evoked alterations of glial and neuronal cell morphology in the guinea-pig retina. J Neurosci 2004;24:10149-10158.

(2) Pannicke T, Iandiev I, Uckermann O, Biedermann B, Kutzera F, Wiedemann P, Wolburg H, Reichenbach A, Bringmann A. A potassium channel-linked mechanism of glial cell swelling in the postischemic retina. Mol Cell Neurosci 2004;26:493-502.

(3) Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, Skatchkov SN, Osborne NN, Reichenbach A. Müller cells in the healthy and diseased retina. Prog Retin Eye Res 2006;25:397-424.

(4) Bringmann A, Iandiev I, Pannicke T, Wurm A, Hollborn M, Wiedemann P, Osborne NN, Reichenbach A. Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects. Prog Retin Eye Res 2009;28:423-451.

(5) Linnertz R, Wurm A, Pannicke T, Krügel K, Hollborn M, Härtig W, Iandiev I, Wiedemann P, Reichenbach A, Bringmann A. Activation of voltage-gated Na+ and Ca2+ channels is required for vesicular release of glutamate from retinal glial cells implicated in cell volume regulation. Neuroscience 2011;188:23-34. doi: 10.1016/j.neuroscience.2011.04.058.

Structural ..
Start date: October 09
04:00 pm 05:00 pm


Our project is called SPACE-P (Structural Phage Assisted Continuous Evolution of Proteins) and is part of the Synthetic Biology field. It focuses on accelerating the process of developing protein binding partners, which is required in pharmaceutical research as well as biotechnology and many other fields of science. Thus far, phage display is the most commonly used method for the discovery of protein binding partners. In this method a large library of potential binding partners is created where the strongest candidates are selected for further affinity testing. This process is very time consuming, cost intensive, requires human intervention steps, and is limited to the size of the given library. Our platform will make it possible to start with a single molecule, transform it by mutation and selection pressure to improve the binding affinity towards a target protein. This method is not only easy to implement, utilizing simple organisms and devices, but also significantly faster and cheaper than currently used tools.

If you would like to get more information about the team please visit their website 2015.igem.org/Team:TU_Dresden

Retina rege..
Start date: October 16
11:00 am 12:00 pm


Disease or injury to the mammalian retina often leads to gliosis and irreparable vision loss.  In contrast, the zebrafish retina responds to injury by regenerating lost neurons and recovering visual responses.  Key to this successful regeneration are Müller glia that undergo a reprogramming event so they acquire stem cell characteristics and generate a proliferating population of retinal progenitors that regenerate all major retinal cell types. Our studies have identified secreted factors, signal transduction cascades, epigenetic events and gene expression programs that are necessary for Müller glia reprogramming, proliferation and neuronal regeneration.  Recent studies have identified strategies for stimulating Müller glia reprogramming and proliferation in the uninjured retina and have identified secreted factors that contribute to Müller glia quiescence.  Our studies suggest Müller glia respond differently to pro-regenerative stimuli in the uninjured and injured retina.  It is anticipated that by uncovering the mechanisms regulating Müller glia reprogramming and retina regeneration in zebrafish we will be better equipped to suggest strategies for stimulating retina regeneration in mammals.

Goldman, D. Muller glial cell reprogramming and retina regeneration.  Nature Rev Neurosci 2014; 15:431-442.

Zhao, X-F., Wan, J., Powell, C. Ramachandran, R., Myers, M.G. and Goldman, D. Leptin and IL-6 family cytokines synergize to stimulate Muller glia reprogramming and retina regeneration.  Cell Reports 2014; 9:285–297. 

Wan, J., Zhao, X-F., Vojtek, A. and Goldman, D. Retinal injury, growth factors and cytokines converge on b-catenin and pStat3 signaling to stimulate retina regeneration. Cell Reports 2014; 9: 272–284.

Powell, C., Grant, A. R., Cornblath, E. and Goldman, D. Analysis of DNA methylation reveals a partial reprogramming of the Muller glia genome during retina regeneration. Proc Natl Acad Sci USA 2013; 110:19814-19819.

Ramachandran, R., Zhao, X-F. and Goldman, D. Insm1a-mediated gene repression is essential for the formation and differentiation of Muller glia-derived progenitors in the injured retina. Nature Cell Biol, 2012; 14:1013-1023.

RAC D - Bon..
Start date: October 19
04:00 pm 06:00 pm

CRTD Extern..
Start date: October 23
11:00 am 12:00 pm

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