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December 01 - December 31

6 entries found

Start date: December 05
11:00 am 12:00 pm


My LINK network science group (www.linkgroup.hu) is concentrating on the analysis of the topology and dynamics of biological networks, including protein structure networks, proteim-protein interaction networks, signaling networks and chromatin networks. We have recently developed a network dynamics tool, Turbine (www.turbine.linkgroup.hu), which is able to discover the attractor structure of dynamic systems and predict target sets of multi-target drug candidates shifting the cell from a disease state to a healthy state. We have established a biotech startup (www.dzzom.com) to explore the applications of this method. In my lecture I will also summarize my recent concept on plasticity-rigidity cycles forming a general adaptation mechanism, and will show its applications in drug design.

Veres, D., Gyurko, D., Thaler, B., Szalay, K., Fazekas, D., Korcsmaros, T. and Csermely, P. (2015) ComPPI (www.comppi.linkgroup.hu): a cellular compartment-specific database for protein-protein interaction network analysis. Nucleic Acid Res. Database Issue, in press

Kovács, I.A. Mizsei, R. and Csermely P. (2014) A unified data representation theory for network visualization, ordering and coarse-graining. http://arxiv.org/abs/1409.8420

Szalay-Bekő, M., Palotai, R., Szappanos, B., Kovács, I.A., Papp, B. and Csermely, P. (2012) ModuLand plug-in for Cytoscape (www.modules.linkgroup.hu): determination of hierarchical layers of overlapping network modules and community centrality. Bioinformatics, 28, 2202-2204

Korcsmáros, T., Farkas, I.J., Szalay, M. S., Rovó, P., Fazekas, D., Spiró, Z., Böde, C., Lenti, K., Vellai, T and Csermely, P. (2010) Uniformly curated signaling pathways (www.signalink.org) reveal tissue-specific cross-talks, novel pathway components, and drug target candidates. Bioinformatics 26, 2042-2050

Csermely, P., Korcsmáros, T., Kiss, H.J.M., London, G. and Nussinov, R. (2013) Structure and dynamics of biological networks: a novel paradigm of drug discovery. A comprehensive review. Pharmacol. Therap. 138, 333-408 (http://linkgroup.hu/docs/13PharmTher.pdf)

Start date: December 08
End date:  - December 09
09:15 am 04:00 pm


The BIOTEC Forum 2014 "Biomechanics across scales - molecules, cells, tissues" brings together international and local experts in the areas of biomechanics, biophysics, cell and developmental biology. The focus will be on biomechanical processes that are at work on different scales. The goal is to present current developments in this area and to identify commonalities and differences of biomechanical processes independent of scale. Specific topics covered include molecular force generation, the cytoskeleton, cell mechanics, mechanonsensitivity and tissue mechanics - a spectrum that reflects the expertise of biomechanics research in Dresden.

Starting in 2007, the BIOTEC Forum has become an annual open meeting, discussing hot topics in one or more of the research areas represented at the BIOTEC Center of the TU Dresden. The format of the meeting is such that internationally renowned speakers at the forefront of their respective research fields will present and discuss recent scientific advances. The meeting is fully open to local and external scientists, with no conference fee being taken. Own contributions can be made within a postersession.

Registration and abstract submission for the BIOTEC Forum is now open.
There is no registration fee for the conference! Register here

Deadline for abstract submission is end of October, registration is open until mid November. Amongst the abstract submissions we will select several for contributed short talks in addition to the invited speakers' talks.

We plan a conference get-together on Monday evening after a stroll over the christmas market - this is a great opportunity to mingle with the speakers in an informal setting.

Please do also register if you only want to attend the conference and don't want to submit an abstract.

Invited speakers (confirmed):

Chip Asbury, UW Seattle, USA

Guillaume Charras, Center for Nanotech, London, UK

Zvonimir Dogic, Brandeis, USA

Kristian Franze, U of Cambridge, UK

Nicole Gorfinkiel, CBMSO Madrid, Spain

Jonne Helenius, ETH Zürich, Switzerland

Claire Hur, U of Cambridge, UK

Hernán López-Schier, Helmholtz Zentrum München

Scott Manalis, MIT, USA

Erwin Peterman, VU Amsterdam, Netherlands, UK

Giuliano Scarcelli, Harvard, USA

Thomas Surrey, London Research Institute, UK

Jonas Tegenfeldt, Lund University, Sweden

Xavier Trepat, IBEC Barcelona, Spain

David Warshaw, U Vermont, USA

Local organizers: Stefan Diez, Stephan Grill, Jochen Guck

Start date: December 08
04:00 pm 05:00 pm


Michele De Luca has dedicated most of his scientific activities to translational medicine. He is recognised as a leading scientist in squamous epithelial stem cell biology and has been a driving force in the development of epithelial stem cell-mediated cell therapy and gene therapy. Following on early work on the use of human epidermal stem cell cultures in life-saving treatment of massive full-thickness burns and in repigmentation of stable vitiligo and piebaldism by keratinocyte/melanocyte co-colture, he was first to establish human urethral stem cell culture aimed at urethral regeneration in posterior hypospadias (N. Engl. J. Med. 1990). He and his principal collaborator, Graziella Pellegrini, developed human limbal stem cell culture (J. Cell Biol. 1999) for corneal regeneration in patients with severe limbal stem cell deficiency (Lancet 1997; N. Engl. J. Med 2010). This treatment leads to recovery of normal vision and is now used worldwide. De Luca is also pioneering ex-vivo epithelial stem cell-mediated gene therapy for genetic skin diseases. He coordinates the first successful clinical trial to treat junctional epidermolysis bullosa (Nat. Med. 2006; Stem Cell Rep. 2014). De Luca has characterised molecular mechanisms regulating long term proliferative potential, clonal evolution and self-renewal of epithelial stem cells. In particular, he shed light on the role of p63 (different isoforms) and c/EBPδ in regulating the proliferative potential and the self-renewal of human corneal stem cells, respectively (PNAS 2001, 2005; J. Cell Biol. 2007). Notably, his work demonstrated that the clinical success of limbal stem cultures is dependent on a discrete number of stem cells identified as holoclones expressing the ΔNα isoform of p63 (N. Engl. J. Med.  2010, TMM 2011).
Michele De Luca is internationally recognised for his experience in stem cell therapy. He contributed to two reports by the International Society for Stem Cell Research, dealing with new guidelines for responsible translational stem cells research (Cell Stem Cell 2008, 2009).

Selected Publications

Pellegrini G., Traverso C., Franzi A.T., Zingirian M., Cancedda R. and De Luca M. (1997) Long term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. The Lancet. 349:990-993.

Pellegrini G., Dellambra E., Golisano O., Martinelli E., Fantozzi I., Bondanza S., Ponzin D., McKeon F. and De Luca M. (2001) p63 identifies human keratinocyte stem cells. Proc. Natl. Acad. Sci. USA. 98:3156-3161.

Mavilio F., Pellegrini G., Ferrari S., Di Nunzio F., Di Iorio E., Recchia A., Maruggi G., Ferrari G., Bonini C., Capurro S., Conti A., Magnoni C., Giannetti A. and De Luca M. (2006) Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells.  Nat. Med. 12:1397-1402.

Rama P., Matuska S., Paganoni G., Spinelli A., De Luca M. and Pellegrini G. (2010) A long-term study of corneal regeneration and cultures of limbal stem cells. N. Engl. J. Med. 363:147-155.

De Rosa L., Carulli S., Cocchiarella F., Quaglino D., Enzo E., Franchini E., Giannetti A., De Santis G., Recchia A., Pellegrini G. and De Luca M. (2014) Long-term stability and safety of transgenic cultured epidermal stem cells in gene therapy of junctional epidermolysis bullosa. Stem Cell Rep. 2:1-8.

Nano scienc..
Start date: December 12
11:00 am 12:00 pm


In the last few years, there has been a burst in the study and conceiving of new devices for the generation and manipulation of electromagnetic field at the nanoscale, where radiation-matter interaction is strongly enhanced. Several fabrication methods are now available for material preparation and nano-structuring, but only few of them can ensure the stringent design control needed for the effective and reproducible device behavior.
We report, herein, novel processes of micro and nanofabrication techniques for several applications in different research fields.
During the lecture it will be presented selected topics from our research activity. In particular it will be highlighted the results on single molecule detection, Plasmon Polariton conversion to Hot electrons and direct imaging of DNA.

Hot-electron nanoscopy using adiabatic compression of surface plasmons; A Giugni, B Torre, A Toma, M Francardi, M Malerba, A Alabastri, RP Zaccaria ...Enzo Di Fabrizio
Nature nanotechnology 8 (11), 845-852, 2013

M. dal Maschio, D. Ghezzi1, G. Bony, A. Alabastri, G. Deidda, M. Brondi, S. Sulis Sato, R. P. Zaccaria, E. Di Fabrizio, G. M. Ratto, L. Cancedda, "High-performance and site-directed in utero electroporation by a triple-electrode probe" Nature Communication; 3, 960, May 2012

F. De Angelis, F. Gentile, F. Mecarini, G. Das, M. Moretti, P. Candeloro, M.L. Coluccio, G. Cojoc, A. Accardo, C. Liberale, R.P. Zaccaria, G. Perozziello, L. Tirinato, A. Toma, G. Cuda, R. Cingolani and E. Di Fabrizio, "Breaking the diffusion limit with super-hydrophobic delivery of molecules to plasmonic nanofocusing SERS structures", Nature Photonics, 5, 682-687 (2011) DOI: 10.1038/ NPHOTON.2011.222

F. De Angelis, G. Das, P. Candeloro, M. Patrini, M. Galli, A. Bek, M. Lazzarino, I. Maksymov, C. Liberale, L. C. Andreani, and E. Di Fabrizio "Nanoscale chemical mapping using three-dimensional adiabatic compression of surface plasmon polaritons" Nature Nanotechnology, 5 (2010) 67-72. DOI: 10.1038/NNANO.2009.348.

C. Liberale, P. Minzioni, F. Bragheri, F. De Angelis, E. Di Fabrizio, I. Cristiani "Miniaturized all- fibre probe for three dimensional optical trapping and manipulation; Nature Photonics ; Volume: 1; pp.: 723-727; ISBN: 1749-4885, 2007     

Malignant D..
Start date: December 15
04:00 pm 06:00 pm

Rethinking ..
Start date: December 16
02:00 pm 03:00 pm


What do you think about the current state of academic publishing and communication? Does the way researchers make their results public serve well enough? Do you experience pressure to be interesting and make a choice between ‘exciting’ and ‘honest’ data?

For years, we have felt that there has to be a more efficient and fairer way to organize scientific communication. As scientists, we are frustrated with the dominance of the impact factor and how peer review is conducted. That is why someone has to take a step toward realizing a new vision.  Last year we founded ScienceOpen. ScienceOpen is a new community-based Open Access publisher and research network from Berlin and Boston. With the initiative ScienceOpen, we would like to change the current scientific publishing culture and have therefore created a concept of immediate publication followed by transparent evaluation (https://www.scienceopen.com/home). Additionally, the ScienceOpen platform enables reviewing and commenting on over 1 million Open Access publications.

We are deeply committed to developing a different kind of publishing.

Nana Bit-Avragim, MD

Editor/Open Access Outreach

ScienceOpen, Berlin

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