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May 01 - May 31

14 entries found

Insights in..
Start date: May 04
11:00 am 12:00 pm

Description: 

Understanding how the different cell types that build our central nervous system (CNS) communicate and influence one another is key to understand its function. We are interested in the cells which produce myelin in the CNS (oligodendrocytes), the insulating multimembrane layer that surrounds most of our axons. Selected Publications:  Snaidero N, Möbius W, Czopka T, Hekking L.H.P., Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons DA, Nave KA, Simons M (2014) Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell 156:277-290

Czopka T, ffrench-Constant C, Lyons DA (2013). Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in vivo. Developmental Cell 25(6):599-609.

Almeida RG*, Czopka T*, ffrench-Constant C, Lyons DA (2011) Individual axons regulate the myelinating potential of single oligodendrocytes in vivo. Development 138(20):4443-50.

Best of Ost..
Start date: May 04
04:00 pm 06:00 pm

Description: 

Program:


16:00 - 16:10       Introduction by Lorenz Hofbauer

16:10 - 16:35       Markus Hoffmann (Universiyt of Erlangen Nuremberg) Checkpoints of chronicity and regeneration in immune mediated inflammatory diseases

16:35 - 17:00       Anne Dudeck (TU Dresden) Mast cells: sentinels and communicators in skin and bone inflammation and regeneration

17:00 - 17:25       Martina Rauner (TU Dresden) MFG-E8: a novel osteoimmune factor

17:25 - 17:50       Juliane Salbach-Hirsch (TU Dresden) Smart biomaterials for bone regeneration - GAGs that interact with sclerostin

17:50 - 18:00       Discussion and social get-together

Artificial ..
Start date: May 05
05:00 pm 06:00 pm

Description: 

The idea of tiny vessels roaming around in human blood vessels working as surgical nanorobots was first proposed by Richard Feynman, a vision that has triggered imagination in scientists and non-scientists alike. With current advances in nanotechnology, there have been several strategies to realize this dream of a “nanovoyager”, aiming to maneuver artificial nanostructures in biological media for diagnostic and therapeutic applications. We will provide a review of the various approaches that have been used to move artificial nanostructures remotely in fluidic environments in a controllable fashion, with special emphasis on manipulation techniques that rely on small, spatially homogenous magnetic fields.

Ambarish Ghosh received his undergraduate degree in Physics from the Indian Institute of Technology, Kharagpur, India. Subsequently, he did his PhD in Physics from Brown University in 2004, and worked at Harvard University from 2005-2009 as a postdoctoral fellow. In 2009, he joined Indian Institute of Science, Bangalore, India as an Assistant Professor, where he is currently a faculty member at the Centre for Nano Science and Engineering, and associate faculty at the Departments of Physics and Electrical Communication Engineering. His research interests include the study of quantum fluids, plasmonics, driven colloidal particles and their applications in biotechnology.

Adult Neuro..
Start date: May 06
End date:  - May 08
09:00 am 06:00 pm

Description: 

In 2015 we celebrate the 50th anniversary of Joseph Altman's landmark discovery of adult neurogenesis. The 2015 Abcam conference on adult neurogenesis aims at putting the developmental process of adult neurogenesis and its regulation into the wider context of its functional and presumed evolutionary relevance.

Fourth meeting in the series!

Following meetings in Dresden (2007), Frauenchiemsee (2010) and Barcelona (2012), we are delighted to be returning to Dresden for the fourth meeting in the series chaired by Prof Gerd Kempermann (German Center for Neurodegenerative Diseases (DZNE) Dresden, Germany).

Stem cell r..
Start date: May 08
04:00 pm 05:00 pm

Description: 

The fly testis is an excellent model system for studying the regulation of stem cell behaviour through extrinsic niche signals. Because of its simple and organization and genetic tractability it lends itself for studying fundamental principles of stem cell - niche interactions that can then be extended to more complex or medically relevant niches. We are interested both in the functional organization of this model niche as well as in the cell biology of the underlying signaling pathways.

We could recently show that the Hedgehog signalling cascade cooperates with the fly cytokine receptor pathway to control proliferation and differentiation of the somatic testis stem cell pool via the key transcriptional regulator Zfh-1. In this Friday seminar we will describe our attempts at further dissecting the cell biology of Hedgehog pathway activation, and will ask to what extent thinking about stem cells separately from their niche makes sense at all.

Materials a..
Start date: May 11
10:00 am 11:00 am

Description: 

Neuro-electronic implants improve the lives of countless individuals through diagnostic or prosthetic functions. Beyond the success of the cochlear implant or the deep brain pacemaker, we can envisage therapeutic applications in virtually any body system controlled by neurons. Making the most out of this opportunity will depend on the seamless integration of functional implants with the body.  Challenges stem from the kinetic nature and mechanical softness of neural tissues, as well as from our limited ability to control neural circuits with arbitrary selectivity. Overcoming these challenges will increase the longevity and usefulness of neural interfaces.
In this talk, I will summarize our efforts to integrate low modulus engineering materials in implantable neuroelectronic devices that can survive in mechanically challenging environments and integrate with host tissues.  We created an artificial membrane that mimics the mechanical properties of dura mater -   the protective skin around the brain and spinal cord - and integrated elastic electrodes, interconnects and microfluidics to enable multi-modal neuromodulation. Chronically implanted on the surface of the spinal cord (intrathecally), the electronic dura mater was used to restore walking in rats with paralyzing spinal cord injury by delivering precise electro-chemical stimulation to the dormant spinal cord (1). Still in the context of spinal cord injury, we adapted the soft technology to create the sensory arm of a closed-loop bladder control neuroprosthetic system. By using elastomeric microchannels as axonal amplifiers integrated with delicate sensory spinal roots, we have been able to monitor bladder fullness in rats (2). Finally, I will discuss strategies to modulate the cell response at the implant-tissue interface using micro-topographically structured and soft surfaces (3). Soft neural interfaces will enable fundamental new studies of the mechanisms of brain and nerve functions, and start new repair strategies to restore lost functions.

Publications:
1.    I. R. Minev et al., Electronic dura mater for long-term multimodal neural interfaces. Science 347, 159 (2015).
2.    D. J. Chew et al., A Microchannel Neuroprosthesis for Bladder Control After Spinal Cord Injury in Rat. Science Translational Medicine 5, 210ra155 (2013).
3.    I. R. Minev et al., Interaction of glia with a compliant, microstructured silicone surface. Acta Biomaterialia 9, 6936 (2013).

microDimens..
Start date: May 11
02:00 pm 03:00 pm

Description: 

The LMF BIOTEC / CRTD hosts a Zeiss slide scanner (Axio Scan.Z1) optimally suited to create virtual slides e.g. as basis for 3d reconstructions. A concise system overview will be given by Hella Hartmann.

Seeing the ..
Start date: May 13
11:00 am 12:00 pm

Deconvoluti..
Start date: May 15
11:00 am 12:00 pm

Description: 

Since her post-doctoral work with Stanley Korsmeyer, Patricia Ernst has focused on the chromatin-modifying proto-oncogene, MLL1 in hematopoietic stem cell homeostasis and leukemia. She showed that MLL1 is required to sustain hematopoiesis through its actions in hematopoietic stem cells, myelo-erythroid progenitors, and lymphoid progenitors.  Her work combines murine model systems and human cells to understand pathways that can be regulated to manipulate hematopoietic stem cell self-renewal and better treat leukemia.

Probing Sph..
Start date: May 19
11:00 am 12:00 pm

Description: 

Sphingolipids are a fascinating class of membrane lipids, acting both as structural modulators that influence the biophysical properties of cell membranes, and as signalling molecules. Because of this dual structural and regulatory role, these lipids are able to create an interface between environmental inputs, such as nutrition and stress on the one hand, and cellular energy metabolism, survival, and growth—all processes mediated in part by the activities of vesicular membranes. The physical properties of the membrane and how they are influenced by sphingolipids--e.g. fluidity or tension--contribute in a surprisingly complex way to the regulation of signalling processes, for example via clustering, docking, involution, budding, and phase separation, i.e. membrane domain formation.
Our laboratory examines the activities and behaviours of sphingolipids on very different scales, using a variety of techniques: their role in vesicle trafficking and survival in neurons in the brain, using Drosophila as a model, vs. their distribution and effects on membrane properties, at the sub-micron scale. In the physiological context of the fly brain, we have carried out lipidomic studies in different mutants that influence sphingolipid metabolism and degeneration, and in parallel have studied the effects of these mutants on membrane fluidity in the living nervous system, using fluorescence correlation spectroscopy.
To examine sphingolipid behaviours in membranes, we use cell culture as well as synthetic membrane systems--supported lipid bilayers and giant unilamellar vesicles (GUVs). As probes of membrane organization and dynamics, we exploit a strategy that bacterial toxins such as tetanus, and pathogens such as Aβ use to invade cells: they interact with nano-scale assemblages of complex sphingolipids and cholesterol via relatively short peptide motifs. We have developed several probes based on these toxins to trace the diffusion dynamics of sphingolipid domains in live cells, and compare these behaviours with those in artificial membranes. This work may be of long-term interest for the design anti-pathogen decoys, for example using engineered lipid targets.
All of these approaches, from single-molecule analysis of diffusion behaviour in membranes, to sphingolipidomics in the fly brain, contribute to our strategy for understanding sphingolipid dynamics in membranes, cells, and the brain.

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