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May 01 - May 31

6 entries found

How to desi..
Start date: May 05
05:00 pm 07:00 pm

Description: 

The lectures are broadcast live to all participating universities using a Virtual Classroom concept in the EMM Nano programme. Find more information here.

Topological..
Start date: May 12
05:00 pm 07:00 pm

Description: 

The lectures are broadcast live to all participating universities using a Virtual Classroom concept in the EMM Nano programme. Find more information here.

VERSCHOBEN:..
Start date: May 13
10:00 am 11:30 am

Minimal sys..
Start date: May 14
03:00 pm 04:00 pm

Description: 

Link to the conference -  Zoom Meeting ID: 978 6190 3519, Password: 04751

Abstract:

In my group we are interested in understanding how dynamic and force-generating properties of the microtubule cytoskeleton contribute to the spatial organisation of cells. 

Over the years, we have worked on the reconstitution of minimal, functional cytoskeletal systems at increasing levels of complexity. 

Examples are the reconstitution, in artificial confinement, of basic mitotic spindles, and the topic of today: the design of minimal systems for the study of microtubule-based polarity. 

These efforts fit in a long-term ambition to build, in collaboration with others, a complete synthetic cell from scratch.    

5 most important publications:

S. Roth, I.C. Gârlea, M. Vleugel, B.M. Mulder, M. DogteromReconstitution of basic mitotic spindles in cell-like confinement (bioRxiv)

L. Laan, N. Pavin, J. Husson, G. Romet-Lemonne, M. van Duijn, M. Preciado-Lopez, R. D.  Vale, F. Jülicher, S. L. Reck-Peterson, and M. Dogterom, Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters, Cell 148, 502-514 (2012).

P. Bieling, L. Laan, H. Schek, L. Munteanu, L. Sandblad, D. Brunner, M. Dogterom, and T. Surrey, Reconstitution of a microtubule plus-end tracking system in vitro, Nature 450, 1100-1105 (2007)   

J.W.J. Kerssemakers, E.L. Munteanu, L. Laan, T.L. Noetzel, M.E. Janson, and M. DogteromAssembly dynamics of microtubules at molecular resolution, Nature 442, 709-712 (2006).

M. Dogterom and B. Yurke, Measurement of the force-velocity relation for growing microtubules, Science 278, 856 (1997) 

Prof. Dr. Dogterom will be happy to have a chat with who is interested after her talk.

Growing min..
Start date: May 19
05:00 pm 07:00 pm

Description: 

The lectures are broadcast live to all participating universities using a Virtual Classroom concept in the EMM Nano programme. Find more information here.

Active defo..
Start date: May 28
01:00 pm 02:00 pm

Description: 

Link to the conference -  Zoom Meeting ID: 934 2705 8190, Password: 175528

Abstract:

We conceive stripped-down experimental systems that reproduce cellular behaviours in simplified conditions: cytoskeleton dynamics are reproduced on liposome membranes. By changing experimentally membrane tension and the structural details of the cytoskeleton architecture, we draw a phase diagram where inward or outward deformations are favoured. We observe buckling and wrinkling under osmotic deflation, thereby confirming network elastic properties. Our results illustrate the generic mechanism of buckling and wrinkling found in various systems spanning from pollen grains to the development of the gut or the brain.

Inspired by actin forces exerted on membranes and organelles, we address now how the nucleus, which is the most rigid cell organelle, is deformed by the actin cytoskeleton during cell translocation.

5 most important publications:

C. Simon, V. Caorsi, C. Campillo, C. Sykes, "Interplay between membrane tension and the actin cytoskeleton determines shape changes",Physical Biology, 5(6):065004, doi: 10.1088/1478-3975/aad1ab. (2018)

A. Allard, M. Bouzid, T. Betz, C. Simon, M. Abou-Ghali, J. Lemière, F. Valentino, J. Manzi, F. Brochard-Wyart, K. Guevorkian, J. Plastino, M. Lenz, C. Campillo*, C. Sykes*, "Actin modulates shape and mechanics of tubular membranes” bioRxiv 712505; doi: https://doi.org/10.1101/712505, and, Science advances in press

C. Simon, R. Kusters, V. Caorsi, A. Allard, M. Abou-Ghali, J. Manzi, A. Di Cicco, D. Lévy, M. Lenz, J.-F. Joanny, C. Campillo, J. Plastino, P. Sens, C. Sykes " Actin dynamics drive cell-like membrane deformation " Nature Physics, https://doi.org/10.1038/s41567-019-0464-1 (2019)

R. Kusters, C. Simon, R. Lopes Dos Santos, V. Caorsi, Sangsong Wu, J.-F. Joanny, P. Sens, C. Sykes, “Actin shells control buckling and wrinkling of biomembranes” Soft Matter, 15, 9647 – 9653 doi: 10.1039/c9sm01902b (2019)

P.M. Davidson, A. Battistella, T. Déjardin, T. Betz, J. Plastino, N. Borghi, B. Cadot, C. Sykes “Actin accumulates nesprin-2 at the front of the nucleus during confined cell migration” bioRxiv 713982; doi: https://doi.org/10.1101/713982, EMBO Reports, in press

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