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December 01 - December 31

5 entries found

Lessons fro..
Start date: December 03
03:00 pm 04:00 pm

Description: 

Baylor College Scientist Presents Update on Osteogenesis Imperfecta

Dr. med. Ingo Grafe, a German clinician scientist currently working with the group of Brendan Lee at the Department of Molecular and Human Genetics at Baylor College of Medicine in Houston, Texas, will give a talk on osteogenesis imperfecta on 3rd December at 3 pm in the lecture hall at house 19 (DINZ) in a joint symposium of the Center for Healthy Aging (UCGA) and the Center for Rare Diseases (UCSE) at UKD. He will give new insights into the therapy of the disease and will present novel therapeutic targets for its treatment both in adults and children. The research group of Prof. Brendan Lee is one of the most prestigious and productive genetic bone groups in the US and Dr. Grafe is looking forward to sharing his expertise with both clinicians and scientists here in Dresden.

All physicians, scientists, and students are welcome.

For more information, view the program.

Brendan Lee Lab:
https://www.bcm.edu/research/labs/brendan-lee

Benign isle..
Start date: December 04
03:00 pm 04:00 pm

Why do sens..
Start date: December 10
04:00 pm 05:00 pm

Description: 

Abstract
Sensitive periods are increasingly well-understood at the neural-physiological level. However, we know little about the evolutionary selection pressures that produce sensitive periods. In this talk, I will present a formal modeling approach to studying the evolution of sensitive periods. We model development as a specialization process during which individuals incrementally adapt to local environmental conditions, while sampling imperfect cues to the environmental state. We first compute optimal developmental mechanisms (i.e., decision rules) for a range of ecological conditions. Then we expose these mechanisms to experiences to obtain developmental trajectories and distributions of mature phenotypes. Our results show that genetically identical individuals who develop in the same environment diverge phenotypically due to stochastic variation in experiences. Moreover, the stability of individual differences increases with advancing age. These findings dovetail with empirical observations in rodents made at the CRT.

5 most recent papers
Fawcett, T. W., & Frankenhuis, W. E. (2015). Adaptive explanations for sensitive windows in development. Frontiers in Zoology, 12 (Suppl. 1): S3.

Frankenhuis, W. E., Nettle, D., & McNamara, J. M. (2018). Echoes of early life: Recent insights from mathematical modeling. Child Development, 89, 1504-1518.

Frankenhuis, W. E., & Panchanathan, K. (2011). Balancing sampling and specialization: An adaptationist model of incremental development. Proceedings of the Royal Society B, 278, 3558-3565.

Panchanathan, K., & Frankenhuis, W. E. (2016). The evolution of sensitive periods in a model of incremental development. Proceedings of the Royal Society B, 283, 20152439.

Stamps, J., & Frankenhuis, W. E. (2016). Bayesian models of development. Trends in Ecology and Evolution, 31, 260-268.

A vision fo..
Start date: December 11
04:00 pm 05:00 pm

Description: 

DIPP Vision Talks aim at giving insight into the research fields represented in the DIPP. They offer - from the perspective of the speaker's expertise - a significant overview of the field, including open questions, existing resources and techniques, challenges and the possible future developments.

http://www.dresden-ipp.de/curriculum/training/dipp-vision-talks/  

The Dresden International PhD Program (DIPP) is jointly organized by the Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB) and the International Max Planck Research School for Cell, Developmental and Systems Biology (IMPRS-CellDevoSys).

From encode..
Start date: December 13
04:00 pm 05:00 pm

Description: 

Outline of the talk
Virtually all drugs are molecular (be them large or small) capable of binding to one or more target proteins of biomedical interest. Thus, the isolation of binders to protein targets is a central step in the drug discovery process. Two methodologies, which rely on the preparation of very large encoded combinatorial libraries, have revolutionized the way protein ligands are discovered. On one hand, antibody phage display libraries (pioneered by Sir Gregory Winter, Nobel Prize Chemistry 2018) allow the construction and screening of very large collections, comprising billions of different antibodies. On the other hand, DNA-encoded chemical libraries allow the construction and screening of large collections of small molecules, individually coupled to DNA tags, serving as amplifiable indentification barcodes. In this lecture, I will show how antibody phage libraries and DNA-encoded chemical libraries have been used in my laboratory (in collaboration with the Philogen group), in order to generate products, which are currently investigated in clinical trials.

Recent Publications of the Neri Group

Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2. Cazzamalli S, Ziffels B, Widmayer F, Murer P, Pellegrini G, Pretto F, Wulhfard S, Neri D. Clin Cancer Res. 2018 Aug 1;24(15):3656-3667.

Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold. Li Y, De Luca R, Cazzamalli S, Pretto F, Bajic D, Scheuermann J, Neri D. Nat Chem. 2018 Apr;10(4):441-448.

Chemically Defined Antibody- and Small Molecule-Drug Conjugates for in Vivo Tumor Targeting Applications: A Comparative Analysis. Cazzamalli S, Dal Corso A, Widmayer F, Neri D. J Am Chem Soc. 2018 Feb 7;140(5):1617-1621.

DNA-Encoded Chemical Libraries: A Selection System Based on Endowing Organic Compounds with Amplifiable Information. Neri D, Lerner RA. Annu Rev Biochem. 2018 Jun 20;87:479-502.

Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8+ T-cell Recognition of a Retroviral Antigen. Probst P, Kopp J, Oxenius A, Colombo MP, Ritz D, Fugmann T, Neri D. Cancer Res. 2017 Jul 1;77(13):3644-3654.

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