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February 01 - February 29

5 entries found

“M-CSF indu..
Start date: February 07
04:00 pm 05:00 pm

Description: 

 

Abstract (Michael Sieweke, Kandalla Prashanth Kumar):

Immune suppressed patients with leukopenia are highly susceptible to viral infections such as Cytomegalovirus (CMV), a**major cause of post hematopoietic stem cell transplantation (HSCT) morbidity and mortality. Immuno-therapies that could reconstitute anti-viral immune competence have not been identified so far. Here we show that M-CSF/CSF-1, a key cytokine of myelo-monocytic differentiation, surprisingly promoted rapid reconstitution of antiviral activity and protection from MCMV viremia in a mouse model of HSCT by stimulating NK cell differentiation and activation.

Abstract (Sebastian Zeißig, Kenneth Peuker):

Immune checkpoint inhibition has revolutionized the treatment of selected cancer entities, but has largely failed to demonstrate efficacy in some of the most common malignancies including colorectal cancer (CRC). The mechanisms of failure of checkpoint inhibition in CRC, however, are poorly understood. In this seminar, we will discuss the identification of a novel network of crosstalk between myeloid tumor-infiltrating cells, T cells and epithelial tumor cells, which promotes intestinal tumor development and metastasis through inhibition of cytotoxic T cell responses. We will discuss how barrier dysfunction and microbial translocation into tumors elicits cytokine responses by tumor-infiltrating myeloid cells, which in turn promote the expression of co-inhibitory proteins by the tumor epithelium to inhibit cytotoxic T cell responses. Finally, we will show that interference with this pathway in mice results in the activation of anti-tumor immunity, regression of established metastatic disease and durable disease control.

 ... followed by social hour! Everybody is welcome!

Can we grow..
Start date: February 11
05:00 pm 07:00 pm

Description: 

The lectures are broadcast live to all participating universities using a Virtual Classroom concept in the EMM Nano programme. Find more information here.

From transi..
Start date: February 18
05:00 pm 07:00 pm

Description: 

The lectures are broadcast live to all participating universities using a Virtual Classroom concept in the EMM Nano programme. Find more information here.

How nanotec..
Start date: February 25
05:00 pm 07:00 pm

Description: 

The lectures are broadcast live to all participating universities using a Virtual Classroom concept in the EMM Nano programme. Find more information here.

Protein Seq..
Start date: February 27
01:00 pm 02:00 pm

Description: 

 

5 most important publications:

Toth-Petroczy A*, Palmedo P*, John Ingraham JI, Thomas A. Hopf TA, Berger B, Sander C, Marks DS. Structured states of disordered proteins from genomic sequences. Cell 2016, 167(1):158-70.

Rockah-Shmuel L, Toth-Petroczy A, Sela A, Wurtzel O, Sorek R and Tawfik DS. The Occurrence and Bypass of Frame-shifting Insertion-Deletions (InDels) to give Functional Proteins are correlated. PloS Genetics 2013 (10) e1003882

Dellus-Gur E*, Toth-Petroczy A*, Elias M, Tawfik DS. What makes a protein fold amenable to functional innovations? Fold polarity and stability trade-offs. J Mol Biol 2013; 425(14):2609-21.

Toth-Petroczy A and Tawfik DS. Protein insertions and deletions enabled by neutral roaming in sequence space. Mol Biol Evol 2013; 30(4):761-71.

Tóth-Petróczy A and Tawfik DS. Slow protein evolutionary rates are dictated by surface-core association. PNAS 2011, 108(27):11151-6.

Abstract:

Protein sequence space is vast, the possibilities are astronomical, yet only a tiny fraction of it is sampled by existing proteins. We mine evolutionary information from millions of genomes to understand how protein families evolve, and what rules govern their functional and structural divergence. We focus not only on genetic mutations but also on phenotypic mutations, i.e mutations introduced by transcriptional and translational machinery. We wish to answer how proteins remain robust to mutations and facilitate innovations at the same time. We combine bioinformatics, modelling and experimental evolution to answer fundamental questions about molecular evolution.

Everybody is very welcome!

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