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November 01 - November 30

14 entries found

Shaping Cel..
Start date: November 05
11:00 am 12:00 pm

Transposons..
Start date: November 06
01:00 pm 02:00 pm

Transplanta..
Start date: November 08
03:00 pm 04:00 pm

Description: 

Abstract:

The retinal pigment epithelium (RPE) plays a pivotal role for the retina and in age-related macular degeneration (AMD), the most common cause of blindness in industrialised societies. The RPE also spearheads developments for cell therapeutics from pluripotent stem cells, whereby their application in AMD may hold the promise of curing the disease. 

 

Publications:
1: Stanzel B, Ader M, Liu Z, Amaral J, Aguirre LIR, Rickmann A, Barathi VA, Tan
GSW, Degreif A, Al-Nawaiseh S, Szurman P. Surgical Approaches for Cell
Therapeutics Delivery to the Retinal Pigment Epithelium and Retina. Adv Exp Med
Biol. 2019;1186:141-170. doi: 10.1007/978-3-030-28471-8_6. PubMed PMID: 31654389.


2: Sharma R, Khristov V, Rising A, Jha BS, Dejene R, Hotaling N, Li Y, Stoddard
J, Stankewicz C, Wan Q, Zhang C, Campos MM, Miyagishima KJ, McGaughey D,
Villasmil R, Mattapallil M, Stanzel B, Qian H, Wong W, Chase L, Charles S, McGill
T, Miller S, Maminishkis A, Amaral J, Bharti K. Clinical-grade stem cell-derived 
retinal pigment epithelium patch rescues retinal degeneration in rodents and
pigs. Sci Transl Med. 2019 Jan 16;11(475). pii: eaat5580. doi:
10.1126/scitranslmed.aat5580. Erratum in: Sci Transl Med. 2019 Feb 6;11(478):.
PubMed PMID: 30651323.

3: Stanzel BV, Liu Z, Somboonthanakij S, Wongsawad W, Brinken R, Eter N, Corneo
B, Holz FG, Temple S, Stern JH, Blenkinsop TA. Human RPE stem cells grown into
polarized RPE monolayers on a polyester matrix are maintained after grafting into
rabbit subretinal space. Stem Cell Reports. 2014 Jan 2;2(1):64-77. doi:
10.1016/j.stemcr.2013.11.005. eCollection 2014 Jan 14. PubMed PMID: 24511471;
PubMed Central PMCID: PMC3916756.

4: Liu Z, Yu N, Holz FG, Yang F, Stanzel BV. Enhancement of retinal pigment
epithelial culture characteristics and subretinal space tolerance of scaffolds
with 200 nm fiber topography. Biomaterials. 2014 Mar;35(9):2837-50. doi:
10.1016/j.biomaterials.2013.12.069. Epub 2014 Jan 15. PubMed PMID: 24439407.

5: Binder S, Stanzel BV, Krebs I, Glittenberg C. Transplantation of the RPE in
AMD. Prog Retin Eye Res. 2007 Sep;26(5):516-54. Epub 2007 Mar 6. Review. PubMed
PMID: 17532250.

11. Retina-..
Start date: November 09
10:00 am 03:00 pm

Description: 

11. Retina-Informationstag
Netzhaut-Forschung in Dresden

10:00 Uhr Grußwort von Karin Papp,
Stellvertretende Vorstandsvorsitzende, PRO RETINA Deutschland e. V.

Grußwort von Bürgermeisterin Frau Dr. Kristin Klaudia Kaufmann
Geschäftsbereich Arbeit, Soziales, Gesundheit und Wohnen der Landeshauptstadt Dresden

10:20 Uhr Dr. Mike O. Karl (CRTD/DZNE)
Menschliche Netzhaut-Organoide: Neue Chancen für die Therapieentwicklung bei Retinitis Pigmentosa und Makuladegeneration

10:45 Uhr Kaffeepause, Informationsstände

11:30 Uhr OA PD Dr. Dr. med. Boris Viktor Stanzel (Augenklinik Sulzbach, Knappschaftsklinikum Saar GmbH)
Zelltherpeutika für die Netzhaut aus Stammzellen: Wo stehen wir?

11:55 Uhr Dr. med. Dirk Sandner (Klinik und Poliklinik für Augenheilkunde am UKD)
Aktuelle Behandlungsmethoden diabetischer Augenveränderungen

12:20 Uhr Mittagspause, Informationsstände

13:20 – 14:20 Uhr Frageforum – Von der Entdeckung im Labor zur Therapie für den Patienten.
Die Referenten der Vorträge beantworten Ihre Fragen rund um das Thema Netzhauterkrankungen
Moderation: Prof. Dr. Elisabeth Knust

15:00 Uhr Ende der Veranstaltung

Forschungszentrum für Regenerative Therapien (CRTD) an der Technischen Universität Dresden
Begehbares Augenmodell - Die Welt aus der Sicht von Patienten mit Netzhauterkrankungen erleben

PRO RETINA Deutschland e.V.
Informationen zum Angebot der Selbsthilfegruppe

Blinden- und Sehbehinderten Verband Sachsen e.V. (BSVS)
Informationen zum Projekt "Blickpunkt Auge" und zu den Angeboten des BSVS

Universitätsklinikum Carl Gustav Carus
Beratung der Klinik und Poliklinik für Augenheilkunde

Flyer

Enhanced, S..
Start date: November 11
02:00 pm 03:00 pm

Size contro..
Start date: November 11
03:00 pm 04:00 pm

Wie kann ma..
Start date: November 13
10:00 am 10:45 am

CRISPR engi..
Start date: November 14
02:00 pm 03:00 pm

Description: 

Prof. Kathrin Schumann from TUM (Munich) will talk about CRISPR engineering immune cells towards clinical translation. Kathrin Schumann was trained at the Marson and Bluestone labs at UCSF. Her research focuses on engineering HIV resistant T cells, engineering improved CAR T cells, and dissecting transcriptional regulation in human regulatory T cells.

Link to her lab webpage with publications:

http://www.mikrobio.med.tum.de/Projekt_AG_Schumann

Blood vesse..
Start date: November 14
04:00 pm 05:00 pm

Description: 

Abstract:
"Research of the past two decades has revealed that the vascular and the central nervous systems (CNS) share many regulatory  cellular molecular principles. Although it is clear that both systems regulate each other during development, homeostasis and disease, the molecular mechanisms of those cross-talks remain poorly characterize. Here, I will summary the work performed and undergoing in my group to understand how the neural compartment regulates vascular growth and patterning during CNS development, and viceversa, how we found that the vasculature is also an active player in neurodevelopment."

De novo thy..
Start date: November 15
04:00 pm 05:00 pm

Description: 

Abstract:

Although regeneration abilities are generally restricted among vertebrates, the axolotls are exceptional in their capacity to regenerate complete limbs post-amputation as well as large parts of various organs including the brain, spinal cord or heart. We have recently found that, even more extraordinarily, the axolotl can regenerate a complete organ – the thymus – /de novo/. The thymus is the primary organ of the adaptive immune system playing a crucial role in T-cell development and specialization. We use a combination of imaging, tissue transplantation and single-cell RNA sequencing (scRNA-seq) approaches to address which molecular players are crucial for thymus regeneration, which cell type gives rise to the new structure, and whether the regenerated organ is completely functional. Ultimately, this work will contribute to our understanding of the cellular and molecular basis for de novo thymus regeneration and maintenance, of both basic and translational relevance.

... followed by Social Hour!

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