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March 01 - March 31

18 entries found

Diabetes re..
Start date: March 05
03:00 pm 04:00 pm

Description: 

Speaker: Marius Distler, Department for Visceral, Thoracic and Vascular Surgery
Title: Diabetes research from a surgeonsperspective-future perspectives for collaboration

Speaker: Petrina Delivani, Angela Hommel, Marie-Luise Zielmann, Regenerative Therapies for Diabetes, CRTD
Title: Update on the type 1 diabetes genetic screening Freder1k and the primary prevention trial POInT.

 

 

Semiconduct..
Start date: March 05
05:00 pm 06:00 pm

A genetic p..
Start date: March 08
11:00 am 12:00 pm

Description: 

Abstract
Coloration is an important and fascinating feature in the biology of an organism. It plays key roles in several fundamental physiological, ecological, and evolutionary processes. My research focus are the molecular, genomic and developmental underpinnings of color patterns in cichlid fishes. Here, in a few million years, over 1,200 species of cichlid fishes have evolved to form repeated adaptive radiations in the East African lakes Victoria, Tanganyika, and Malawi giving rise to an astonishing diversity of species displaying various color patterns. My recent work gives insights into the genetic basis of repeated evolution and diversification of stripe patterns, and the importance of gene regulatory evolution for these processes.

More information: http://www.claudius-kratochwil.com

5 most recent papers
Kratochwil CF, Liang Y, Gerwin J, Woltering JM, Urban S, Henning F, Machado-Schiaffino G, Hulsey CD, and Meyer A. (2018). Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiations. Science 362:457-460.

Di Meglio T*, Kratochwil CF*, Vilain N, Loche A, Vitobello A, Yonehara K, Roska B, Peters AHFM, Wellik D, Ducret S, and Rijli FM (2013). Ezh2 orchestrates topographic tangential migration and connectivity of precerebellar neurons. Science 339 (6116), 204-207.

Kratochwil CF and Meyer A (2015). Closing the genotype-phenotype gap: Emerging technologies for evolutionary genetics in ecological model vertebrate systems. BioEssays 37 (2), 213-226.

Kratochwil CF*, Geissler L*, Irisarri I*, and Meyer A (2015). Molecular evolution of the neural crest regulatory network in ray-finned fish. Genome Biology and Evolution 7 (11), 3033-3046.

Kastenhuber E*, Kratochwil CF*, Ryu S*, Schweitzer J, and Driever W (2010). Genetic dissection of dopaminergic and noradrenergic contributions to catecholaminergic tracts in early larval zebrafish. J Comp Neurol 518 (4), 439-458.

Function-ba..
Start date: March 08
01:00 pm 02:00 pm

Description: 

Abstract

Blindness alone affects 34 million people worldwide according to WHO (2016). Several diseases, such as retinitis pigmentosa, Leber's Congenital Amaurosis, Glaucoma and age-related macular degeneration due result in the functional impairment of vision impairment and ultimately blindness. Multiple therapeutic approaches have been developed during last decays including: neuroprotection, gene therapy, antibody therapy, optogenetics, neuroprotection, retinal prosthesis, and cell replacement therapy. As the utmost parameter of these therapies, we need to examine retinal functionality in animal models. To this end we quantified retinal coding diversity by the development of a visual characterization toolbox by which responses of retinal ganglion cells to different visual inputs were classified.

Colloidal c..
Start date: March 08
04:00 pm 05:00 pm

Description: 

Part 1 - BIOTEC

Speaker: Jochen Guck, Katrin Wagner (Postdoc)
Title: "Colloidal crystals of layered compliant microgel beads to study 3D cell migration and mechanosensitivity in vitro"

Part 2 - LUMICKS B.V., Amsterdam

Speaker: Philipp Rauch
Title: "Single-cell acoustic force spectroscopy (scAFS)- a novel approach to quantify cell adhesion"

Part 3 - CRTD

Speakers: Jared Sterneckert, Vadreenath Tripathy (Predoc)
Title: "A novel approach to protecting MNs from ALS"

Everybody is welcome!

Seminconduc..
Start date: March 12
05:00 pm 06:00 pm

The proprio..
Start date: March 13
04:00 pm 05:00 pm

Description: 

Abstract
The musculoskeleton is a tremendously sophisticated and complex biomechanical organ system. It allows vertebrates, including us humans, to display a vast repertoire of movement and postural patterns and, consequently, of behaviors and functions. Our main goal is to understand the biological and biomechanical principles governing musculoskeletal development and function, maintenance and regeneration, as well as aging and pathology. Deciphering the mechanisms underlying these processes will pave the way for development of new therapeutic approaches for treatment of numerous musculoskeletal diseases, including congenital and degenerative, and injuries.

Papers
New functions for the proprioceptive system in skeletal biology. Blecher R, Heinemann-Yerushalmi L, Assaraf E, Konstantin N, Chapman JR, Cope TC, Bewick GS, Banks RW, Zelzer E. Philos Trans R Soc Lond B Biol Sci. 2018 Sep 24;373(1759).

Mechanical regulation of musculoskeletal system development. Felsenthal N, Zelzer E. Development. 2017 Dec 1;144(23):4271-4283.

Tendon-to-bone attachment: from development to maturity Zelzer E, Blitz E, Killian ML, Thomopoulos S.

Birth Defects Res C Embryo Today. 2014 Mar;102(1):101-12. Franziska Knopf, Dr. Tatiana Sandoval Guzmán, Holger Henneicke, MD PhD, Jacqueline Tabler

Function an..
Start date: March 14
04:00 pm 05:00 pm

Description: 

Abstract
We demonstrate that amyloid plaque seeding is increased in the absence of functional TREM2. Increased seeding is accompanied by decreased microglial clustering around newly seeded plaques and reduced plaque associated Apolipoprotein E (ApoE). Reduced ApoE deposition in plaques is also observed in brains of AD patients carrying TREM2 coding variants. Proteomic analyses and microglia depletion experiments revealed a microglial origin of plaque associated ApoE. Longitudinal amyloid small animal positron emission tomography demonstrates accelerated amyloidogenesis in TREM2 loss of function mutants at early stages, which progressed at a lower rate with aging. These findings suggest that in the absence of functional TREM2 early amyloidogenesis is accelerated due to reduced phagocytic clearance of amyloid seeds despite reduced plaque associated ApoE.

The 5 most important publications
Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Sebastian Monasor L, Tahirovic S, Willem M, Pettkus N, Butovsky O, Bartenstein P, Edbauer D, Rominger A, Ertürk A, Jucker M, Holtzman DM, Meyer-Luehmann M, Haass C. Loss of TREM2 function increases amyloid seeding but reduces plaque associated ApoE. Nature Neuroscience, 22(2): 191-204.

Suárez-Calvet M, Caballero MA, Kleinberger G, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Ewers M, Haass C for the Dominantly Inherited Alzheimer Network (2016) Early changes of CSF sTREM2 in Dominantly Inherited Alzheimer's Disease follow markers of Amyloid Deposition and Neuronal Injury. Science Translational Medicine 8(369): 369ra178.

Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Muller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Muller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C (2015) eta-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature 526 :443-7.

Kleinberger G., Yamanishi Y., Suárez-Calvet M., Czirr E., Lohmann E., Cuyvers E., Struyfs H., Pettkus N., Wenninger-Weinzierl A., Mazaheri F., Tahirovic S., Lleó A., Alcolea D., Fortea J., Willem M., Lammich S., Molinuevo J. L., Sanchez-Valle R., Antonell A., Ramirez A., Heneka M., Sleegers K., van der Zee J., Martin J.-J., Engelborghs S., Demirtas-Tatlidede A., Zetterberg H., Van Broeckhoven C., Gurvit H., Wyss-Coray T., Hardy J., Colonna M. & Haass C. (2014) TREM2 mutations linked to neurodegeneration impair cell surface transport and phagocytosis. Science Translational Medicine, 6, 1-29.

Willem, M., Garratt, A.N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., DeStrooper, B., Saftig, P., Birchmeier, C. and Haass, C. (2006) Control of peripheral nerve myelination by the beta-secretase BACE1. Science 314, 664-6.

Stammzellen..
Start date: March 15
09:00 am 02:45 pm

Description: 

 

Start: 9:00 Uhr Begrüßung und Videoübertragung

Quiz: Fragen zu Stammzellen

Stammzellen im Fokus

  9:45 - 10:15 Vortrag "Regeneration & Stammzellen: Beispiel Auge"
10:15 - 10:45 Vortrag "Stammzellen und Diabetes"
10:45 - 11:00 Vortrag "Gesunde Blutstammzellen versus Leukämie-Stammzellen"
11:00 - 11:15 Pause
11.15 - 11.30 Vortrag "Stammzellen im Gehirn"
11.30 - 11.45 Vortrag "Stammzellen im Knochen"
11.45 - 12.00 Quiz reloaded
12.00 - 13.00 Lunch
13.00 - 14:30 "Stammzellen erleben" (buntes Nachmittagsprogramm mit Vorträgen, Workshops, Diskussionen und eigenen Experimenten)
14:30 - 14:45 Austausch, Evaluation und Verabschiedung

Wo: Technische Universität Dresden, DFG - Forschungszentrum für Regenerative Therapien Dresden (CRTD) - Exzellenzcluster an der TU Dresden Fetscherstraße 105, 01307 Dresden

Wer: Schülerinnen und Schüler der Biologie-Leistungskurse in der Sekundarstufe II

Wie: Anmeldung durch die Lehrerin oder den Lehrer unter recruitment(at)crt-dresden.de

Da das Platzangebot begrenzt ist, werden die Plätze in der Reihenfolge der Anmeldung vergeben.

Novel conce..
Start date: March 19
05:00 pm 06:00 pm

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