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November 01 - November 30

13 entries found

Self-organi..
Start date: November 08
04:00 pm 05:00 pm

Description: 

Abstract
A defining feature of living systems is the capacity to break symmetry and generate well-defined forms and patterns through self-organisation. Our group aims to understand the principle of multi-cellular self-organisation using early mouse embryos as a model system. Our studies revealed that morphogenesis and gene expression are highly dynamic and stochastically variable during blastocyst development. Determining which signal breaks the symmetry and how the blastocyst establishes a reproducible shape and pattern despite the preceding variability remains fundamental open questions. Integrating biology, physics and mathematics, we study how molecular, cellular and physical signals are dynamically coupled across the spatial and temporal scales for self-organisation during early mammalian development.

5 most recent papers
Korotkevich, E., Niwayama, R., Courtois, A., Friese, S., Berger, N., Buchholz, F. and Hiiragi, T. The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo. Developmental Cell (2017) 40(3), 235-247.e7.

Maître, J.-L., Turlier, H., Illukkumbura, R., Eismann, B., Niwayama, R., Nedelec, F. and Hiiragi, T. Asymmetric division of contractile domains couples cell positioning and fate specification. Nature (2016) 536(7616), 344-348.

Maître, J.-L., Niwayama, R., Turlier, H., Nédélec, F. and Hiiragi, T.: Pulsatile cell-autonomous contractility drives compaction in the mouse embryo. Nat Cell Biol (2015) 17, 849-855.

Ohnishi, Y., Huber, W., Tsumura, A., Kang, M., Xenopoulos, P., Kurimoto, K., Oleś, A.K., Araúzo-Bravo, M.J., Saitou, M., Hadjantonakis, A.-K. and Hiiragi, T.: Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages. Nat Cell Biol (2014) 16, 27-37.

Gene therap..
Start date: November 09
03:00 pm 04:00 pm

Description: 

Abstract
The Fischer group aims to bring promising new therapies to patients with retinal disorders and conducted the first retinal gene therapy trial in Germany. With a focus on genetic therapies, our mission is to understand disease processes leading to blindness, developing treatment strategies and testing promising new drugs in clinical trials.

5 most recent papers
Changes in retinal sensitivity after gene therapy in choroideremia. Fischer et al., Retina 2018: First report on clinical gene therapy trial on eyes in Germany.

AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye. Reichel et al. Mol Ther 2017: Immune considerations in regard to retinal gene therapy.

Codon-Optimized RPGR Improves Stability and Efficacy of AAV8 Gene Therapy in Two Mouse Models of X-Linked Retinitis Pigmentosa. Fischer et al. Mol Ther 2017: Codon optimisation as a mean to sidestep genetic fragility of RPGR for gene therapy.

High Symmetry of Visual Acuity and Visual Fields in RPGR-Linked Retinitis Pigmentosa. Bellingrath et al., Invest Ophthalmol Vis Sci. 2017: This is our initial cohort for RPGR gene therapy. We define suitable endpoints.

Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function. Michalakis et al., Mol Ther. 2010: POC paper for the CNGA3 gene therapy trial.

One beta-ce..
Start date: November 09
04:00 pm 05:00 pm

Description: 

Abstract
In this seminar we will ask a fundamental question related to the behavior of the insulin-producing pancreatic beta-cells. Specifically, we will challenge the idea that all beta-cells are functionally equivalent. Using high speed calcium imaging in the zebrafish pancreas, we have collected evidence for the presence of a critical sub-population of beta-cells. These cells, which we term Leaders, appear to orchestrate the function of the entire islet. Damaging or silencing Leaders can impair the pan-islet response to glucose. Thereby, we reveal that in vivo, the function of an entire islet can fail due to the loss of a small but critical sub-population of its constituent cells. This knowledge might become critical when considering how to regenerate or replace beta-cells in order to cure diabetes.

10. Retina-..
Start date: November 10
10:00 am 03:00 pm

Description: 

Der 10. Netzhaut-Informationstag bietet Ihnen aktuelle Informationen zu Themen aus der Grundlagen- und klinischen Forschung, sowie neue Möglichkeiten der Anwendung und Selbsthilfe. Im Mittelpunkt stehen die Erkrankungen Retinitis Pigmentosa, Makuladegeneration und das manifeste Glaukom.

Programm

10:00 Uhr
Grußwort von Karin Papp, Stellvertretende Vorstandsvorsitzende, PRO RETINA Deutschland e. V.
Grußwort von Sächsischer Staatsministerin für Soziales und Verbraucherschutz Barbara Klepsch verlesen durch Prof. Dr. Elisabeth Knust, Direktorin, MPI-CBG

10:20 Uhr
Prof. Dr. Marius Ader, CRTD, Dresden
Zell-Transplantation in die Netzhaut - aktueller Stand der Forschung

10:40 Uhr
Vortrag des Universitätsklinikums Dresden

11:00 Uhr
Kaffeepause, Informationsstände

11:40 Uhr
Prof. Dr. Domink Fischer, Universität Tübingen, Forschungsinstitut für Augenheilkunde
Wie funktioniert Gentherapie am Auge?

12:00 Uhr
Carola Engelmann, SFZ Förderzentrum gGmbH
Das neue Bundesteilhabegesetz - Erweiterte Regelungen zu Nachteilsausgleichen

12:10 Uhr
Dario Rizzo, SFZ Förderzentrum gGmbH
Selbstbestimmt und eigenständig - auch mit Sehbehinderung! Angebote zur Rehabilitation

12:20 Uhr
Mittagspause, Informationsstände

13:20 - 14:20 Uhr
Frageforum - Von der Entdeckung im Labor zur Therapie für den Patienten. Die Referenten der Vorträge beantworten Ihre Fragen rund um das Thema Retina
Moderation: Prof. Dr. Elisabeth Knust

15:00 Uhr
Ende der Veranstaltung

DFG-Forschungszentrum für Regenerative Therapien an der Technischen Universität Dresden
Begehbares Augenmodell - Die Welt aus der Sicht von Patienten mit Netzhauterkrankungen erleben

PRO RETINA Deutschland e.V.
Informationen zum Angebot der Selbsthilfegruppe

Blinden- und Sehbehinderten Verband Sachsen e.V. (BSVS)
Informationen zum Projekt "Blickpunkt Auge" und zu den Angeboten des BSVS

SFZ Förderzentrum gGmbH
Informationen zu Rehabilitationsangeboten

Universitätsklinikum Carl Gustav Carus
Beratung der Klinik und Poliklinik für Augenheilkunde

Sehzentrumfachgeschäft Dresden & Blinden- und Sehbehinderten Verband Sachsen e.V.
Fragen rund um den Blindenführhund

Flyer

Regulation ..
Start date: November 16
04:00 pm 05:00 pm

Description: 

Abstract
Salamanders have the remarkable ability to regenerate their entire limbs throughout life. Limb regeneration is an accurate process which gives rise exclusively to the missing structures and in the correct proportions, irrespective of the amputation level. This suggests that cells in the stump have a memory of their position within the limb, a property termed 'positional identity'. At present, very little is known about how positional identity is encoded at the molecular level and how it interplays with tissue growth. Through a single cell RNAseq approach as well as a protein-interaction screen, we recently identified the Tig1 tumour suppressor as a potential determinant of proximal identity. Tig1 exhibits graded expression along the proximodistal axis, is regulated by the proximalising factor retinoic acid, and is able to change the fate of distal cells to more proximal locations along the regenerating limb. In this talk, we will discuss evidence supporting the role of Tig1 as a new determinant of proximodistal identity, as well as its functions in regulating limb proportions during salamander limb regeneration.

Neuroscienc..
Start date: November 19
04:00 pm 06:00 pm

Description: 

We would like to invite you to our next CRTD (RAC C) Symposium on "Neuroscience - from Bench to Bedside" on Monday, 19th November 2018, 4:00 pm at the CRTD, auditorium left.

Program

4:00 - 4:05 Introduction by Prof. Andreas Hermann

4:05 - 4:35 Dr. Christian Lange (Brand group, CRTD)
Adventures in (pseudo)time and space - single cell sequencing identifies functional subpopulations of newborn neurons in the adult zebrafish brain.

4:35 - 4:55 Dr. Kevin Peikert (Hermann group, Dept. Neurology, TUD)
Targeting Lyn kinase in Chorea-Acanthocytosis: A bench to bedside translation in an ultra-rare disease.

4:55 - 5:15 Dr. René Günther (Hermann group, Dept. Neurology, TUD)
Modelling SOD1-ALS: From Bench to Bedside.

5:15 - 5:35 Lara Marrone (Sterneckert group, CRTD)
Modelling FUS amyotrophic lateral sclerosis using isogenic iPSC reporter lines - with a particular focus on impaired granulostasis and protein homeostasis.

5:35 - 6:00 Discussion and social get-together

Single cell..
Start date: November 20
04:00 pm 05:00 pm

Karriere in..
Start date: November 22
03:30 pm 04:30 pm

Coordinatio..
Start date: November 22
04:00 pm 05:00 pm

Description: 

Abstract
During tissue development morphogen signaling controls both pattern formation and tissue growth. In turn the profiles of morphogen activity depend on the molecular and biophysical properties of tissues. The goal of our research is to unravel the feedbacks between cell fate specification, tissue growth and morphogen signaling in the developing spinal cord. Understanding how these processes are coordinated will provide insight into how the reproducibility and accuracy of spinal cord development is achieved.


5 most recent papers

Decoding of position in the developing neural tube from antiparallel morphogen gradients. 
Zagorski M, Tabata Y, Brandenberg N, Lutolf MP, Tkacik G, Bollenbach T, Briscoe JKicheva A.
Science (2017) 356(6345):1379-1383.

The roles of negative feedback and Gli regulation in the dynamics of Shh signaling. 
Cohen M, Kicheva A, Ribeiro A, Blassberg R, Page K, Briscoe J.
Nature Comm(2015): 6, 6709.

Coordination of progenitor specification and growth in mouse and chick spinal cord. 
Kicheva A, Bollenbach T, Ribeiro A,Valle HP, Rovell-Badge R, Episkopou V, Briscoe J.
Science (2014): 345 (6204):1254927.

Developmental pattern formation: insights from physics and biology.
Kicheva A, Cohen M, Briscoe J.
Science (2012): 338, 210.

Kinetics of morphogen gradient formation.
Kicheva A§, Pantazis P§, Bollenbach T§, Kalaidzidis Y, Bittig T, Jülicher F & González-Gaitán M.
Science (2007): 315, 521-5.

Evo Devo – ..
Start date: November 28
09:30 am 11:00 am

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