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June 01 - June 30

9 entries found

The functio..
Start date: June 04
11:00 am 12:00 pm


5 most important publications:

Baden T, Berens P, Franke K, Román Rosón M, Bethge M, Euler T. The functional
diversity of retinal ganglion cells in the mouse. Nature. 2016 Jan
21;529(7586):345-50. doi: 10.1038/nature16468. Epub 2016 Jan 6.

2: Euler T, Haverkamp S, Schubert T, Baden T. Retinal bipolar cells: elementary
building blocks of vision. Nat Rev Neurosci. 2014 Aug;15(8):507-19. Review.

3: Becker AJ, Urbach H, Scheffler B, Baden T, Normann S, Lahl R, Pannek HW,
Tuxhorn I, Elger CE, Schramm J, Wiestler OD, Blümcke I. Focal cortical dysplasia
of Taylor's balloon cell type: mutational analysis of the TSC1 gene indicates a
pathogenic relationship to tuberous sclerosis. Ann Neurol. 2002 Jul;52(1):29-37.

4: Baden T, Chagas AM, Gage GJ, Marzullo TC, Prieto-Godino LL, Euler T. Open
Labware: 3-D printing your own lab equipment. PLoS Biol. 2015 Mar
20;13(3):e1002086. doi: 10.1371/journal.pbio.1002086. eCollection 2015 Mar.

5: Baden T, Berens P, Bethge M, Euler T. Spikes in mammalian bipolar cells
support temporal layering of the inner retina. Curr Biol. 2013 Jan 7;23(1):48-52.
doi: 10.1016/j.cub.2012.11.006. Epub 2012 Dec 13.

Start date: June 05
03:30 pm 04:30 pm


Dr. Hebrok's work focuses on understanding the mechanisms underlying pancreas development and disease, including Diabetes and Pancreatic cancer. His research on the role of embryonic signaling pathways in these processes has provided a glimpse into how tight regulation of these signaling events is imperative for proper organogenesis and formation of functional beta cells. His lab has used the information gained from these developmental studies to understand processes underlying the dedifferentiation and dysfunction of pancreatic beta cells. In addition, his group has been optimizing differentiation conditions to generate functional beta cells from human embryonic stem cells and converted fibroblasts. The goal of his studies is to study human beta cell biology with the intent of preventing or reversing defective processes that occur during the development and progression of diabetes.

5 selected publications:

1. Thayer*, S. P., Pasca di Magliano, M., Heiser, P.W., Roberts, D. J., Nielsen, C. M., Lauwers, G. Y., Qi, Y.P., Gysin, S., Fernandez-del Castillo, F., Yajnik, V., Antoniu, B., McMahon, M., Warshaw, A. L., and M. Hebrok* (2003): Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425, 851 - 856. * Co-corresponding authors. PMC3688051

2. Puri, S., Akiyama, H., and M. Hebrok (2013): VHL-mediated disruption of Sox9 activity compromises ß-cell Identity and Results in Diabetes.Genes & Development. 2013 Dec 1;27(23):2563-75. doi: 10.1101/gad.227785.113. PCMID: PMC3861670.

3. von Figura, G., Fukuda, A., Liku. M. E., Morris, J. P., Kim, G. E., Russ, H. A., Firpo, M. A., Mulvihill, S., Mueller, W. F., Busch, A., Hertel, K. J., and M. Hebrok (2013): Loss of Brg1 Cooperates with Oncogenic Kras to Form Intraductal Papillary Mucinous Neoplasm and Pancreatic Ductal Adenocarcinoma. Nature Cell Biology, 2014 Mar;16(3):255-67. doi: 10.1038/ncb2916. Epub 2014 Feb 23. PMC4684081.

4. Russ, H. A., Parent, A. V., Ringler, J. J., Hennings, T. G., Nair, G. G., Shveygert, M., Guo, G., Puri, S., Haataja, L., Cirulli, V., Szot, G., Arvan, P. and M. Hebrok (2015): Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro. Embo J.,2015 Apr 23. pii: e201591058. PMCID: PMC4516429

5. Zhu, S., Russ, H. A., Wang, W., Hebrok*, M., and S. Ding* (2016): Direct conversion of human fibroblasts into endodermal progenitors giving rise to functional beta-like cells. Nature Communications, 2016 Jan 6;7:10080. doi: 10.1038/ncomms10080. PMCID: PMC4729817.*Co-corresponding authors.

Chronic Mas..
Start date: June 12
02:00 pm 03:00 pm



Chronic massively parallel recordings in superficial areas of large mammals such as humans and non-human primates have been feasible for almost a decade, due to the advent of Utah arrays and similar multiwire arrays. However, in smaller brains and in deep-seated areas, such approaches have not been successful. We use a new approach: electrochemically-roughened, carbon-nanotube-coated, thin twisted tetrodes. We conduct massively parallel recording of tens of single units per tetrode, for months, with isolated units stable for several weeks. This technique opens up new possibilities in rodent neurophysiology relating to development, learning, pathological processes, and aging.

Recent Publications:

Takagaki K, Ohl FW (2017)
Coarse-Graining to Investigate Cerebral Cortex Dynamics.
in Complexity and Synergetics pp 289-299.

Takagaki K, Morales MK, Vitantonio D, Berkowitz F, Bell WL, Kumar PN, Motamedi GK (2016)
Periodic Lateralized Epileptiform Discharges (PLEDs) in Patients With Neurosyphilis and HIV Infection. Clin EEG Neurosci. 47(3):247-50.

Takagaki K, Russell J, Lippert MT, Motamedi GK (2015)
Development of the posterior basic rhythm in children with autism. Clinical Neurophysiology. 126(2):297-303.

Huang XY, Xu W, Liang J, Takagaki K, Gao X, Wu JY (2010)
Spiral wave dynamics in neocortex. Neuron. 68(5):978-990.

Takagaki Keq, Lippert MTeq, Dann B, Wanger T, Ohl FW (2008)
Normalization of voltage-sensitive dye signal with functional activity measures.
PLoS ONE. 3(12):e4041.

Protein Eng..
Start date: June 14
04:00 pm 05:00 pm



Protein-based tools are at the core of many of strategies to study brain function as they endow a high degree of specificity, allow highlighting designated types of neurons and their subcellular structures, and permit implantation deeply into living brains.  Proteins are used as sensors to monitor activity or biochemistry of neurons, to control or block action potential firing of neurons, or to manipulate circuits on longer time scales by pharmaco-genetics. As such, they typically exploit the talents evolved in nature, but they rarely come to application in their native form. Often, many iterative cycles of improvements and adaptations are necessary, domains of different origins may need to be recombined, and often several screening and design strategies may need to be tried and validated to finally obtain a variant that performs highly in a real physiological experiment.  In my presentation I will outline some of the multidisciplinary optimization approaches used in the field to create useful tools for research in cell biology and neuroscience.

Recent Publications:

C. SCHNAITMANN, V. HAIKALA, E. ABRAHAM, V. OBERHAUSER, T. THESTRUP, O. GRIESBECK, D.F. REIFF (2018). Color Processing in the Early Visual System of Drosophila. Cell 172:318–330.

T. THESTRUP, J. LITZLBAUER, I. BARTHOLOMÄUS , M. MUES, L. RUSSO,  H. DANA, Y. KOVALCHUK, Y. LIANG, G. WITTE, T.W. CHEN, S. BECKER, Y. LAUKAT, T. ALLEN, L.C. ROME, A. GEIGER , D.S. KIM, O. GARASCHUK, C. GRIESINGER, O. GRIESBECK (2014). Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T-lymphocytes. Nature Methods 11:175-82.

Q.-T. NGUYEN, L. F. SCHROEDER, M. MANK , A. MULLER, P. W. TAYLOR, O. GRIESBECK, D. KLEINFELD (2010). An in vivo biosensor for neurotransmitter release and exogenous receptor activity. Nature Neuroscience 13:127-32.

M.MANK, A. FERRAO SANTOS, S. DIRENBERGER, T. MRSIC-FLÖGEL, S. HOFER, V. STEIN, C. LEVELT, D.F. REIFF, T. HENDL, A. BORST, T. BONHOEFFER, M.HÜBENER, O. GRIESBECK (2008). A genetically encoded calcium indicator for chronic in vivo two photon imaging. Nature Methods 5:805-811.

O. GRIESBECK, G.S. BAIRD, R.E. CAMPBELL, D.A. ZACHARIAS, R.Y. TSIEN (2001). Reducing the environmental sensitivity of yellow fluorescent protein: mechanism and application. J. Biol. Chem. 276:29188-94.

Lange Nacht..
Start date: June 15
End date:  - June 16
06:00 pm 01:00 am



The role of..
Start date: June 18
10:30 am 11:30 am

Start date: June 19
04:00 pm 05:00 pm

Kreisläufe ..
Start date: June 20
10:00 am 11:30 am

The genetic..
Start date: June 22
04:00 pm 05:00 pm


Abstract 1st talk:

I study the effect of temperature on the fertility of nematodes. C. elegans remains fertile across a range of temperature that match those experienced in its habitat. However, extremes of high and low temperature render it infertile. How then do different nematodes change their physiology to adapt to a new temperature niche? Manipulating P granules, which are liquid-like organelles that program cells to become the future gonad, can change the fertility at low temperature. This result leads to a model where the liquid properties of P granules influence the temperature dependence of fertility.

Abstract 2nd talk:

Regeneration requires a proper interaction of the new forming tissue with the old remaining one. In axolotl limb, bone is a prominent component that undergoes a dramatic resorption upon amputation. The mechanisms associated with this process are unknown. We aim to describe the dynamics of bone resorption and the cell types that are involved in it. Unravelling how this process takes place is important for understanding how successful bone regeneration occurs.

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