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Amyloid-beta42 mediated neurodegeneration in adult zebrafish brain and its response

PhD / Postdoc Seminar

Date:22.05.2015, 16:00 - 17:00
Speaker: Caghan Kizil, Prabesh Bhattarai
Location: CRTD, auditorium left

Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder characterized by different morphological culprits, one of which is deposition of Amyloid peptides in forms of intracellular aggregates or extracellular senile plaques that lead to gradual neuronal loss. One of the reasons why we cannot circumvent and counteract this disease is the lack of neurogenic input from neural stem cells of the mammalian brains. Zebrafish, on the other hand, can regenerate its brain after various insults such as severe traumatic injuries, and therefore offers an excellent model to study the molecular mechanisms how neural stem cells can be reprogrammed to form neurons after damage and regenerate the neurons. To address such molecular programs, we are in need of generating neurodegeneration models in adult zebrafish brain. Here we use a manual microinjection method, cerebroventricular microinjection (CVMI), to inject amyloid peptides into the adult zebrafish brain to mimic amyloid deposition. We found that amyloid depositions in the brain resulted in cell death, hence displaying an acute neurodegenerative condition. Furthermore, amyloid inclusions also showed immediate inflammatory response and synaptic degeneration. In contrast to mammalian brains, amyloid deposition in zebrafish brain initiated reactive proliferation of radial glial cells and subsequent neurogenesis, indicating that zebrafish has the neurogenic plasticity of its neural stem cells upon neurodegeneration. Our transcriptional profiling experiments led to differential expression of multiple genes, which we are functionally analyzing for their relevance to neurodegeneration-induced plasticity. Our results point to a fundamental difference in regenerative plasticity response between mammalian and zebrafish neural stem cells, and to their molecular signatures.



Efficient learning and generalization in networks with "material" synapses: theory and message-passing algorithms

BIOTEC Green Seminar

Date:29.05.2015, 11:00 - 12:00
Speaker: Prof. Riccardo Zecchina, Politecnico di Torino, Dept. for Applied Science and Technology Human Genetics Foundation, Torino
Location: CRTD, auditorium left
Host: Carlo V. Cannistraci

Research Activity:
The research interests of Riccardo Zecchina lie at the interface between statistical physics, computational neuroscience and computational biology. The main themes include equilibrium and out-of-equilibrium modelling, statistical physics of inverse problems for data analysis, statistical inference and combinatorial optimization, learning theory and regulatory networks. The research activity covers fundamental aspects as well as the design of efficient algorithms.

Publications:
Determining computational complexity from characteristic `phase transitions' , Nature 400, 133 (8-July-1999), with R. Monasson, S.Kirkpatrick, B.Selman, L.Troyansky

Analytic and Algorithmic Solution of Random Satisfiability Problems , Science 297, 812 (2002) (Sciencexpress published on-line 27-June-2002; 10.1126/science.1073287), with M.Mezard and G.Parisi;

Efficient supervised learning in networks with binary synapses  , C. Baldassi, A. Braunstein, N. Brunel, R. Zecchina, Proc. Nat. Acad. Sci. (PNAS) 104, 11079-11084 (2007)

Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments, U. Ala et. al., PNAS 110, 7154 (2013)

3D Protein Structure Predicted from evolutionary sequence variation   , D.S. Marks et. al,  PLoS O NE 6, e28766 (2011)

Category: Green Seminar


9th CRTD Summer Conference on Regenerative Medicine

Date:05.06.2015, 09:00 - 21:00
Location: CRTD

Submission Deadline for abstracts: 4. May 2015
Submit your abstract to make this conference a fruitful experience!

Call for posters (link)
Website: webapp.biotec.tu-dresden.de/summer2015


New interactive poster session

  • An online abstract book will be available to all registrants.
  • Posters will be mixed and not be separated by research areas.
  • All posters will be presented within 5 minute slots in parallel poster sessions. Be aware to explain your project also to newbies!
  • As part of the poster interaction we will award a seed grant (max. 15.000 EUR) for postdocs. Please use the abstract book to prepare yourself and the breaks at the poster session to start discussing putative projects and collaborations. Submit a proposal online until 6.7.2015 to Andrea Meinhardt (andrea.meinhardt@crt-dresden.de). Upon positive evaluation the applicants can start their project on 1.10.2015.


BIOTEC Green Seminar 26.06.2015

BIOTEC Green Seminar

Date:26.06.2015, 11:00 - 12:00
Speaker: Prof. Eberhard Bodenschatz, Max-Planck-Institute for Dynamics and Self-Organization Fluid Dynamics, Pattern Formation and Biocomplexity
Location: CRTD, auditorium left
Host: Jochen Guck
Category: Green Seminar


BIOTEC Green Seminar 10.07.2015

BIOTEC Green Seminar

Date:10.07.2015, 11:00 - 12:00
Speaker: Prof. Alfred Nordheim, Eberhard Karls Universität Tübingen, Molecular Biology
Location: CRTD, auditorium left
Host: Jörg Mansfeld
Category: Green Seminar


BIOTEC Green Seminar 18.09.2015

BIOTEC Green Seminar

Date:18.09.2015, 11:00 - 12:00
Speaker: Prof. Pierre Magistretti, King Abdullah University of Science and Technology, Biological and Environmental Sciences and Engineering
Location: CRTD, auditorium left
Host: Carlo V. Cannistraci
Category: Green Seminar


12th Dresden Symposium on Autoantibodies


Date:23.09.2015, 09:00 - 26.09.2015, 18:00
Location: CRTD


BIOTEC Green Seminar 16.10.2015

BIOTEC Green Seminar

Date:16.10.2015, 11:00 - 12:00
Speaker: Prof. Dan Goldman, Georgia Institute of Technology, Complex Rheology and Biomechanics
Location: CRTD, auditorium left
Host: Jörg Mansfeld
Category: Green Seminar


BIOTEC Green Seminar 13.11.2015

BIOTEC Green Seminar

Date:13.11.2015, 11:00 - 12:00
Speaker: Prof. Helmut Schiessel, Universiteit Leiden, Theoretical Physics of Life Processes
Location: CRTD, auditorium left
Host: Jochen Guck
Category: Green Seminar


BIOTEC Green Seminar 11.12.2015

BIOTEC Green Seminar

Date:11.12.2015, 11:00 - 12:00
Speaker: Prof. Moritz Helmstaedter, Max-Planck-Institute for Brain Research, Department of Connectomics
Location: CRTD, auditorium left
Host: Carlo V. Cannistraci
Category: Green Seminar

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