Examplepictures of DNA-Structures


The mechanical genome

BIOTEC Green Seminar

Date:04.12.2015, 11:00 - 12:00
Speaker: Prof. Helmut Schiessel, Universiteit Leiden, Lorentz Institute for Theoretical Physics, Netherlands
Location: BIOZ, 5th floor, room 1
Host: Jochen Guck

Abstract: My group studies the three-dimensional arrangements of DNA molecules inside cells. Currently we explore the possibility that mechanical information is hidden inside the base-pair sequence of genomes. This information contains mechanical cues that e.g. guide the folding of the DNA molecule that carries this information. We were able to show that this mechanical information can be multiplexed with classical genetic information (as one can have two phone conversations on the same wire). This suggests the possibility of a mechanical evolution of DNA molecules that takes place in parallel and independent of the classical evolution of genomes. The methods employed by my group range from analytical treatments (using methods from statistical and classical mechanics) to computer simulations. Publications: R. D. Schram, G. T. Barkema and H. Schiessel, On the stability of fractal globules. J. Chem. Phys. 138, 224901-1-11 (2013).

M. Emanuel, G. Lanzani and H. Schiessel, Multi-plectoneme phase of double-stranded DNA under torsion. Phys. Rev. E 88, 022706-1-20 (2013).

A. Fathizadeh, A. B. Besya, M. R. Ejtehadi and H. Schiessel, Rigid body molecular dynamics DNA inside a nucleosome. Eur. Phys. J 36, 21-1-10 (2013).

M. Depken and H. Schiessel, Nucleosome shape dictates chromatin-fiber structure. Biophys. J. 96, 777-784 (2009).

I. M. Kulic and H. Schiessel. DNA spools under tension. Phys. Rev. Lett. 68, 228101 (2004).

Category: Green Seminar

3D-Bioprinting: a versatile tool for research on regenerative therapies?

CRTD RAC F Symposium

Date:07.12.2015, 16:00 - 18:00
Speaker: Yixin Zhang (B Cube TUD),
Ralf Zimmermann (Leibniz Institute of Polymer Research Dresden),
Anja Lode (Centre for Translational Bone, Joint and Soft Tissue Research, Medical Faculty, TUD)
Location: CRTD, Auditorium left
Host: Prof. Michael Gelinsky

16:00 - 16:30 Introduction by Michael Gelinsky (Centre for Translational
Bone, Joint and Soft Tissue Research, Medical Faculty, TUD)

16:30 - 16:50 Yixin Zhang (B Cube TUD)

"Non-covalent hydrogels: from screening to engineering"

16:50 - 17:10 Ralf Zimmermann (Leibniz Institute of Polymer Research

"3D-Printing of zonal hydrogel scaffolds"

17:10 - 17:30 Anja Lode (Centre for Translational Bone, Joint and Soft
Tissue Research, Medical Faculty, TUD)

"3D plotting of cell-laden alginate/methylcellulose blends – a simple
and versatile method for diverse bioprinting approaches"

17:30 - 18:00 Discussion and social get-together

Stem Cells and Regenerative Biomedicine


Date:11.12.2015, 09:00 - 12:30
Speaker: Boris Fehse (Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany),
Michael Sieweke (Centre d'Immunologie de Marseille-Luminy CIML, Marseille, France),
Francesca Peri (EMBL, Heidelberg, Germany),
Jochen Rink (MPI-CBG, Dresden, Germany)
Location: CRTD, auditorium left
Host: Elly Tanaka


9:00 - 9:10    Welcome by Elly Tanaka
9:10 - 9:55    Boris Fehse (Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany)

    "Permanent genome modification for research and cell-therapy applications"

9:55 - 10:40    Michael Sieweke (Centre d'Immunologie de Marseille-Luminy CIML, Marseille, France)

    "Beyond stem cells: Macrophage self-renewal and pro-regenerative activity"

10:40 - 11:00    Coffee Break
11:00 - 11:45    Francesca Peri (EMBL, Heidelberg, Germany)

    "The brain under surveillance: the role of neuronal-microglial interactions in the development and repair of the CNS"

11:45 - 12:30    Jochen Rink (Max Planck Institute of Cellular Biology and Genetics, Dresden, Germany)

    "Comparative analysis of flatworm regeneration: Towards system requirements of regeneration"

Pioneers in Science 11.12.2015

Pioneers in Science

Date:11.12.2015, 14:00 - 15:00
Speaker: Prof. Eric Warrant, Lund University, Department of Biology, Sweden
Location: CRTD, auditorium left
Host: Cristina Golfieri

Stem Cell Models of Neural Regeneration and Disease

ISSCR International Symposia 2016

Date:01.02.2016, 08:00 - 03.02.2016, 17:00
Location: CRTD
Host: Elly Tanaka

Stem Cell Models of Neural Regeneration and Disease will highlight the latest directions of neural stem cell research, including emerging techniques in model systems, that are moving the field to new understandings of disease and toward therapeutic applications. Hear from leaders in neural stem cell biology and neurodegenerative disorders, those who model neural regeneration, and  those who are driving stem-cell based products into clinical trials.


Confirmed Speakers:

- Oliver Brüstle, MD University of Bonn and LIFE & BRAIN GmbH, Germany

- Doo Yeon Kim, PhD, Massachusetts General Hospital/ Harvard Medical School, USA

- Juergen A. Knoblich, PhD, IMBA-Institute of Molecular Biotechnology, Austria

- Mototsugu Eiraku, PhD, Center for Developmental Biology, RIKEN, Japan
- Frederick J. Livesey, PhD, Gurdon Institute, United Kingdom

- Guo-Li Ming, MD, PhD, Johns Hopkins University, USA

- Lawrence S.B. Goldstein, PhD, University of California - San Diego, USA

- Ana Martin-Villalba, MD, PhD DKFZ German Cancer Research Center, Germany

- Frank Bradke, PhD, German Center for Neurodegenerative Diseases (DZNE), Germany

- Jonas Frisén, MD, PhD, Karolinska Institute, Sweden

- Robin Franklin, PhD, Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, United Kingdom

- Steven A. Goldman, MD, PhD, University of Copenhagen, Denmark

- Malin Parmar, PhD, Lund University, Sweden

- Lorenz Studer, MD, Sloan-Kettering Institute for Cancer Research, USA

- Sally Temple, PhD, Neural Stem Cell Institute, USA

- Peter Coffey, BSc, DPhil, University College London Institute of Ophthalmology, United Kingdom

- Elly Tanaka, Center for Regenerative Therapies Technische Universität Dresden, Germany

Category: General


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