Examplepictures of DNA-Structures

Events


O & U vernetzt Synergien stärken - Redundanz vermindern

19. Tagung des Arbeitskreises Mitteldeutscher Orthopäden und Unfallchirurgen (AMOU)

Date:06.03.2015, 12:30 - 07.03.2015, 13:30
Location: CRTD
Host: Prof. Dr. med. Klaus-Peter Günther, Prof. Dr. med. Hans Zwipp

Das übergeordnete Tagungsthema "O & U vernetzt" bringt unser Ziel zum Ausdruck: es soll eine Plattform geschaffen werden, um verschiedenen Gruppen und Verbänden die Möglichkeit zur Mitgestaltung zu geben, die im Themenbereich der muskuloskelettalen Erkrankungen und Verletzungen auf unterschiedlichen Ebenen in unserer Region aktiv sind. Im Rahmen von Plenarvorträgen werden unterschiedliche und teilweise auch sehr kontroverse Themen aus den verschiedenen Blickwinkeln beleuchtet, die sowohl für Kliniker als auch niedergelassene Kollegen interessant sein dürften. Daran beteiligen sich Vertreter des Sächsischen Sportärztebundes, der Landesverbände von BVOU und VLOU sowie der Traumanetzwerke Ostsachsen und West¬sachsen.

Das bewährte Konzept der Workshops soll weitergeführt werden. Unter anderem geben sie eine Möglichkeit zur Standortbestimmung in wichtigen Qualitätsinitiativen der Endoprothetik (zertifizierte Endoprothetikzentren) bzw. Verletztenversorgung (Traumanetzwerke) und werden durch eine Demonstration neuer Techniken von Industriepartnern ergänzt. Nicht zuletzt soll den beteiligten Verbänden auch ein Rahmen für die Möglichkeit zu internen Arbeitssitzungen gegeben werden, um den zeitlichen Aufwand für häufig parallele Aktivitäten zu reduzieren.

Wir hoffen, mit diesem Konzept eine angestrebte Stärkung von Synergien zu erreichen und freuen uns über die engagierte Beteiligung aller Mitveranstalter. Wie immer ist vielleicht der kulturelle Rahmen Dresdens ein zusätzlicher Grund, wieder einmal einen Besuch in der sächsischen Landeshauptstadt zu planen.

Wir würden uns gemeinsam mit allen Mitveranstaltern sehr freuen, Sie im März 2015 als Gäste der AMOU bei uns begrüßen zu dürfen.

 

Prof. Dr. med. Klaus-Peter Günther

Geschäftsführender Direktor

 

Prof. Dr. med. Hans Zwipp

Ärztlicher Direktor

 



A zoo of single-molecule techniques applied to biological questions

B CUBE Predoc Seminar

Date:06.03.2015, 16:00 - 17:00
Speaker: Michael Schlierf (B CUBE), Ann Mukhortava (Predoc), Martin Ruer (Predoc)
Location: Seminar Room 1 & 2

Over the past years numerous single-molecule techniques have become available to study biological questions. Having these techniques at hand allows us to shine light on long-standing questions of structure-function relationships. After a short overview of which techniques we use for a broad set of questions, we will present two examples. Optical tweezers allow a the denaturation of single proteins by force and, thus, a closer look on protein folding of the small and fast folding lambda repressor and its downhill folder variants. In the second part, we will see how single-molecule FRET experiments on the molecular machine FtsH, a AAA+ protease, reveal that its conformational changes are not driven by ATP and how a pathogenic mutation affects these transitions.



Double Conference on Program of Early Mammalian Development and Systems Biology of Stem Cells


Date:08.03.2015, 16:00 - 12.03.2015, 12:00
Location: Oberstdorf-Haus, Oberstdorf, Germany
Host: Francis Stewart, Andreas Beyer, Edith Heard, Austin Smith

Program of Early Mammalian Development (08-11 March) and Systems Biology of Stem Cells (10-12 March) are the two overlapping conferences with two joint sessions organized by the EU-funded SyBoSS project. A large number of excellent speakers has followed our invitation to winterly Oberstdorf, the most southern village in Germany. Among them will be:
Adrian Bird, Déborah Bourc'his, Anne Ferguson-Smith, Kat Hadjantonakis, Petra Hajkova, Hitoshi Niwa, Mitinori Saitou, Jörn Walter, Raja Jothi, Nevan Krogran, Bo Torben Porse, Mike Rudnicki, Timm Schroeder and many more.

For more information see here: http://syboss.eu/oberstdorf

More speakers will be selected from abstracts.

Here you can download the poster

Register now!




Date:09.03.2015, 09:00 - 13.03.2015, 17:00
Location: CRTD, auditorium left
Host: bts e.V.

GMP (Good Manufacturing Practice, dt. = Gute Herstellungspraxis) sind Richtlinien zur Qualitätssicherung bei der Produktion von Arzneimitteln, Kosmetika, Lebens- und Futtermitteln.
GMP-Kenntnisse werden in vielen Unternehmen von Absolventen aus den Life Sciences erwartet, jedoch in Hochschulen nur selten vermittelt. Oft sind GMP-Kenntnisse eine zentrale Anforderungen bei Stellenausschreibungen, besonders in der Pharmaindustrie. Aus diesem Grund bieten wir einen Lehrgang für Studenten und Absolventen aus den Bereichen Pharmazie, Biochemie, Biologie und angrenzenden Wissenschaften an.
Um den Lehrgang möglichst praxisnah zu gestalten, werden die Inhalte durch Mitarbeiter verschiedener Unternehmen vermittelt.
Deshalb haben wir Referenten von der Dresdner Mühle, AreviPharma, WorldCourier, Reinraum-Akademie, Profi-con, Apogepha, Li-il und der BioType Diagnostic GmbH eingeladen. 



Investigating the Genetics, Structure and Function of the Diseased Retina to Prepare for Clinical Trials

CRTD External Seminar

Date:10.03.2015, 16:00 - 17:00
Speaker: Hendrik Scholl, Wilmer Eye Institute, Johns Hopkins University, Baltimore
Location: CRTD, auditorium right
Host: Marius Ader

Information about the speaker:

Hendrik Scholl is the director of the Retinal Degenerations Clinic of the Retina Division and the director of the Visual Neurophysiology Service. He is also the co-director of Wilmer’s newly founded Center for Stem Cells and Ophthalmic Regenerative Medicine (STORM). He specializes in medical and surgical management of retinal diseases such as age-related macular degeneration (AMD) and diabetic retinopathy. He has a specific expertise in inherited retinal degenerations and uses the latest diagnostic technology such as eletroretinography, microperimetry and high-resolution imaging. Dr. Scholl’s primary

research interest relates to visual loss in retinal degenerations and to therapeutic measures in order to rescue vision. In his leadership role of large multi-center clinical studies, he aims to develop better tools to prove therapeutic efficacy for upcoming clinical trials.


Selected publications:

1. Charbel Issa P, Gillies MC, Chew EY, Bird AC, Heeren TF, Peto T, Holz FG, Scholl HPN (2013). Macular telangiectasia type 2. Prog Retin Eye Res. 34: 49-77. 

2. Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HPN, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ (2011) Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature 478: 76-81.

3. Charbel Issa P, Troeger E, Finger R, Holz FG, Wilke R, Scholl HPN (2010) Structure-function correlation of the human central retina. PLoS One. 22;5(9): e12864.

4. Scholl HPN, Charbel Issa P, Walier M, Janzer S, Pollok-Kopp B, Börncke F, Fritsche LG, Chong NV, Fimmers R, Wienker T, Holz FG, Weber BHF, Oppermann M (2008) Systemic complement activation in age-related macular degeneration. PLoS ONE 3(7):e2593.

5. Scholl HPN, Bellmann C, Dandekar SS, Bird AC, Fitzke FW  (2004) Photopic and scotopic fine matrix mapping of retinal areas of increased fundus autofluorescence in patients with age-related maculopathy. Invest Ophthalmol Vis Sci 45:574-583.



How cells coordinate their decisions across tissues: A Turing system patterns fingers.

CRTD External Semniar

Date:13.03.2015, 11:00 - 12:00
Speaker: Prof. Dr. James Sharpe, Centre for Genomic Regulation, Barcelona Biomedical Research Park, Barcelona
Location: CRTD, auditorium right
Host: Ingo Röder

The research of Dr. Sharpe’s group is focused around a better understanding of vertebrate limb development. The aim is to understand it at the level of gene regulation but also at the level of the physical interactions between cells. Dr. Sharpe’s group includes embryologists, computer scientists, imaging specialists and engineers, applying different methodologies ranging from novel approaches for data-capture (live time-lapse OPT imaging), over finite-element simulations of the growing 3D structure, to computer models of gene regulatory networks responsible for pattern formation. For more details please have a look at the web site of the Sharpe lab: www.crg.eu/en/programmes-groups/multicellular-systems-biology.



Force and Function: Single Molecule Biophysics of Molecular Interactions

BIOTEC Green Seminar

Date:20.03.2015, 11:00 - 12:00
Speaker: Prof. Hermann Gaub, Ludwig-Maximilians-Universtität München, Biophysics and Molecular Materials
Location: CRTD, auditorium left
Host: Jochen Guck

Molecular interactions are the basis of life and forces play a crucial role in both the assembly and the structural integrity as well as the dynamics of all living systems. The regulation of bio-molecular complexes, the maintenance of cellular structures, and even cell signaling are controlled by forces. At the molecular level the relation between these forces and their biological functions have become accessible by the different single molecule force spectroscopy techniques, which evolved in recent years. A deeper understanding of the physics of this relation has emerged from the very fruitful combination of the high resolution and precision of such experiments with the insight in structural rearrangements from all-atom Molecular Dynamics Calculations. In this talk a general overview on this field will be given, followed by a report on recent discoveries: The activation mechanisms of two prominent intracellular force sensors, Myosin Light Chain Kinase and Titin Kinase were elucidated. The clamp-mechanism of catch bonds between Cohesin and Dockerins in the Cellulosome complexes could be resolved. Novel strategies for parallelization of force-measuring assays will be discussed and a new chip based strategy will be introduced starting out from genes providing direct access to the mechanics of the encoded proteins in a one step process. At last, the use of molecular force balances for the analysis of DNA-protein interactions will be presented.



cfaed Spring Research Festival

Date:25.03.2015, 08:00 - 26.03.2015, 18:00
Location: CRTD

The Cluster of Excellence cfaed will celebrate its annual Spring Research Festival at CRTD on 25 March 2015. All nine research paths of cfaed will present their highlights of the past year as well as plans for the coming months. The Cluster's Scientific Advisory Board will closely evaluate the progress made and advise on the future direction of cfaed's program. In addition to scientific presentations, cfaed will display a poster exhibition as well as several technical demonstrations. The huge challenge of the Cluster's program is the highly interdisciplinary work of natural scientists and engineers to follow their vision to explore new technologies for electronic information processing which overcome the limits of today's predominant CMOS technology.



Human pluripotent stem cells: a new tool to understand and treat retinal diseases

Extraordinary CRTD External Seminar

Date:09.04.2015, 16:00 - 17:00
Speaker: Dr. Olivier Goureau, Research Director at INSERM Laboratory of Cellular and Molecular Pathophysiology of the Retina U592, "INSERM", Paris, France
Location: CRTD, auditorium left
Host: Mike Karl

Information about the research of Dr. Goureau:

Our research group aims at understanding retinal differentiation mechanisms and at participating in cell therapy by developing new approaches based on retinal cell regeneration. Our main research fields include the use of human induced pluripotent stem (iPS) cells in cell-based rescue or replacement strategies and in human retinal disease modeling. Our objectives are: i) the development of innovative and robust protocols allowing the differentiation of human iPS cells into different retinal cell types (retinal ganglion cells, photoreceptors and RPE cells) and the ii) derivation of iPS cells from patients affected by specific inherited retinal dystrophies to understand retinal pathological mechanisms and to further develop large-scale drug screening.


Selected publications:

From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium. Reichman S, Terray A, Slembrouck A, Nanteau C, Orieux G, Habeler W, Nandrot EF, Sahel JA, Monville C, Goureau O. Proc Natl Acad Sci U S A. 2014

Involvement of Bcl-2-associated transcription factor 1 in the differentiation of early-born retinal cells. Orieux G, Picault L, Slembrouck A, Roger JE, Guillonneau X, Sahel JA, Saule S, McPherson JP, Goureau O. J Neurosci. 2014

Ciliary neurotrophic factor promotes muller glia differentiation from the postnatal retinal progenitor pool. Goureau O, Rhee KD, Yang XJ. Dev Neurosci. 2004

Inducible nitric oxide synthase mediates the change from retinal to vitreal neovascularization in ischemic retinopathy. Sennlaub F, Courtois Y, Goureau O. J Clin Invest. 2001 Mar;107(6):717-25.

Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transforming growth factor beta in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation. Goureau O, Lepoivre M, Becquet F, Courtois Y. Proc Natl Acad Sci U S A. 1993



BIOTEC Green Seminar 17.04.2015

BIOTEC Green Seminar

Date:17.04.2015, 11:00 - 12:00
Speaker: Prof. Ana Pombo, Max-Delbrück-Centrum Berlin, Epigenetic regulation and chromatin architecture
Location: CRTD, auditorium left
Host: Jörg Mansfeld


Adult Neurogenesis: Evolution, Regulation and Function

ABCAM Neurogenesis Meeting

Date:06.05.2015, 09:00 - 08.05.2015, 18:00
Location: CRTD
Host: Prof. Gerd Kempermann

In 2015 we celebrate the 50th anniversary of Joseph Altman's landmark discovery of adult neurogenesis. The 2015 Abcam conference on adult neurogenesis aims at putting the developmental process of adult neurogenesis and its regulation into the wider context of its functional and presumed evolutionary relevance.

Fourth meeting in the series!

Following meetings in Dresden (2007), Frauenchiemsee (2010) and Barcelona (2012), we are delighted to be returning to Dresden for the fourth meeting in the series chaired by Prof Gerd Kempermann (German Center for Neurodegenerative Diseases (DZNE) Dresden, Germany).



BIOTEC Green Seminar 29.05.2015

BIOTEC Green Seminar

Date:29.05.2015, 11:00 - 12:00
Speaker: Prof. Riccardo Zecchina, Politecnico di Torino, Statistical physics and interdisciplinary applications
Location: CRTD, auditorium left
Host: Carlo V. Cannistraci


BIOTEC Green Seminar 26.06.2015

BIOTEC Green Seminar

Date:26.06.2015, 11:00 - 12:00
Speaker: Prof. Eberhard Bodenschatz, Max-Planck-Institute for Dynamics and Self-Organization Fluid Dynamics, Pattern Formation and Biocomplexity
Location: CRTD, auditorium left
Host: Jochen Guck


BIOTEC Green Seminar 10.07.2015

BIOTEC Green Seminar

Date:10.07.2015, 11:00 - 12:00
Speaker: Prof. Alfred Nordheim, Eberhard Karls Universität Tübingen, Molecular Biology
Location: CRTD, auditorium left
Host: Jörg Mansfeld


BIOTEC Green Seminar 18.09.2015

BIOTEC Green Seminar

Date:18.09.2015, 11:00 - 12:00
Speaker: Prof. Pierre Magistretti, King Abdullah University of Science and Technology, Biological and Environmental Sciences and Engineering
Location: CRTD, auditorium left
Host: Carlo V. Cannistraci


12th Dresden Symposium on Autoantibodies


Date:23.09.2015, 09:00 - 26.09.2015, 18:00
Location: CRTD


BIOTEC Green Seminar 16.10.2015

BIOTEC Green Seminar

Date:16.10.2015, 11:00 - 12:00
Speaker: Prof. Dan Goldman, Georgia Institute of Technology, Complex Rheology and Biomechanics
Location: CRTD, auditorium left
Host: Jörg Mansfeld


BIOTEC Green Seminar 13.11.2015

BIOTEC Green Seminar

Date:13.11.2015, 11:00 - 12:00
Speaker: Prof. Helmut Schiessel, Universiteit Leiden, Theoretical Physics of Life Processes
Location: CRTD, auditorium left
Host: Jochen Guck


BIOTEC Green Seminar 11.12.2015

BIOTEC Green Seminar

Date:11.12.2015, 11:00 - 12:00
Speaker: Prof. Moritz Helmstaedter, Max-Planck-Institute for Brain Research, Department of Connectomics
Location: CRTD, auditorium left
Host: Carlo V. Cannistraci

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