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Mechanisms of epigenetic regulation in stem cells and development

CRTD External Seminar

Date:26.08.2016, 14:00 - 15:00
Speaker: Professor Alexander Meissner (Harvard University, USA)
Location: CRTD, auditorium left
Host: Sara Zocher (CRTD, Kempermann)

Bacillus subtilis – model organism for bacterial multicellular differentiation and microbial cell factory

Green Seminar

Date:02.09.2016, 11:00 - 12:00
Speaker: Thorsten Mascher (Chair of General Microbiology, Institute for Microbiology, TU Dresden)
Location: CRTD, Auditorium left
Host: Francis Stewart



We are interested in how microorganisms, especially the Gram-positive model bacterium Bacillus subtilis, communicate with, and respond to changes occurring within their environment. The primary questions that motivate our research are: What are the molecular mechanisms of novel signal transducing systems with emphasis on the development of antibiotic resistance (molecular biology)? How do such signal transducing systems interdependent within regulatory networks (systems biology)? How can we rewire such systems to orchestrate novel expression programs within bacteria (Synthetic Biology)? Knowledge gained from approaching these central questions is applied to develop genetic tools (e.g. novel expression systems or whole-cell biosensors) or novel concepts (SporoBeads = functionalized biological microparticles) for biotechnological purposes.


Radeck J., Fritz G., and Mascher T. (2016) The cell envelope stress response of Bacillus subtilis: from static signaling devices to dynamic regulatory network. Curr. Genet. (Epub ahead of print)

Pinto D. and Mascher T. (2016) (Actino)Bacterial "intelligence": using comparative genomics to unravel the information processing capacities of microbes. Curr. Genet. 62: 487-98

Wolf D. and Mascher T. (2016) The applied side of antimicrobial peptide-inducible promoters from Firmicutes bacteria: expression systems and whole-cell biosensors. Appl. Microbiol. Biotechnol. 100: 4817-29

Mascher T. (2014) Bacterial (intramembrane-sensing) histidine kinases: signal transfer rather than stimulus perception. Trends Microbiol. 22: 559-565

Mascher T. (2013) Signaling diversity and evolution of extracytoplasmic function (ECF) σ factors. Curr. Opin. Microbiol. 16:148-155

Wecke T. and Mascher T. (2011). Antibiotic research in the age of omics - from expression profiles to interspecies communication. J. Antimicrob. Chemother. 66:2689-704

Category: Green Seminar

Futter für das Denken: der Zusammenhang zwischen Ernährung und Hirnfunktion

Dresdner Seniorenakademie

Date:07.09.2016, 10:00 - 11:30
Speaker: Prof. Dr. Gerd Kempermann
Location: CRTD, Seminarraum 3
Host: Franziska Clauß


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