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Retina regeneration in zebrafish

BIOTEC Green Seminar

Date:16.10.2015, 11:00 - 12:00
Speaker: Prof. Dan Goldman, University of Michigan, Ann Arbor, USA,
Department of Biological Chemistry,
Molecular and Behavioral Neuroscience
Location: CRTD, auditorium left
Host: Michael Brand

Disease or injury to the mammalian retina often leads to gliosis and irreparable vision loss.  In contrast, the zebrafish retina responds to injury by regenerating lost neurons and recovering visual responses.  Key to this successful regeneration are Müller glia that undergo a reprogramming event so they acquire stem cell characteristics and generate a proliferating population of retinal progenitors that regenerate all major retinal cell types. Our studies have identified secreted factors, signal transduction cascades, epigenetic events and gene expression programs that are necessary for Müller glia reprogramming, proliferation and neuronal regeneration.  Recent studies have identified strategies for stimulating Müller glia reprogramming and proliferation in the uninjured retina and have identified secreted factors that contribute to Müller glia quiescence.  Our studies suggest Müller glia respond differently to pro-regenerative stimuli in the uninjured and injured retina.  It is anticipated that by uncovering the mechanisms regulating Müller glia reprogramming and retina regeneration in zebrafish we will be better equipped to suggest strategies for stimulating retina regeneration in mammals.

Goldman, D. Muller glial cell reprogramming and retina regeneration.  Nature Rev Neurosci 2014; 15:431-442.

Zhao, X-F., Wan, J., Powell, C. Ramachandran, R., Myers, M.G. and Goldman, D. Leptin and IL-6 family cytokines synergize to stimulate Muller glia reprogramming and retina regeneration.  Cell Reports 2014; 9:285–297. 

Wan, J., Zhao, X-F., Vojtek, A. and Goldman, D. Retinal injury, growth factors and cytokines converge on b-catenin and pStat3 signaling to stimulate retina regeneration. Cell Reports 2014; 9: 272–284.

Powell, C., Grant, A. R., Cornblath, E. and Goldman, D. Analysis of DNA methylation reveals a partial reprogramming of the Muller glia genome during retina regeneration. Proc Natl Acad Sci USA 2013; 110:19814-19819.

Ramachandran, R., Zhao, X-F. and Goldman, D. Insm1a-mediated gene repression is essential for the formation and differentiation of Muller glia-derived progenitors in the injured retina. Nature Cell Biol, 2012; 14:1013-1023.

Category: Green Seminar

Ready – SET(d) – Go: The H3K4 methyltransferase Setd1b as a crucial player in adult murine haematopoiesis

BIOTEC Predoc Seminar

Date:16.10.2015, 16:00 - 17:00
Speaker: Konstantinos Anastassiadis, Kerstin Schmidt (Predoc)
Location: CRTD, auditorium left
Category: General

RAC D - Bone and More

Joint CRTD/SKELMET-Symposium

Date:19.10.2015, 16:00 - 18:00
Speaker: Clemens Bergwitz (Yale University),
Michael Muders (Institute of Pathology,
Andrew Browne (Bone lab, MK3, UKD),
Christopher Antos (CRTD),
Prayag Murawala (CRTD)
Location: CRTD, auditorium left
Host: Lorenz Hofbauer
Category: General, Medicine

Limits and Limitations in Membrane Protein Structural Biology

DIPP Vision Talk

Date:20.10.2015, 16:00 - 17:00
Speaker: Karim Fahmy, Helmholtz-Zentrum Dresden-Rossendorf
Location: CRTD, auditorium left
Category: General, Biology

Regulation of neural stem cell fate: Between transcription and translation.

CRTD External Seminar

Date:23.10.2015, 11:00 - 12:00
Speaker: Prof. Verdon Taylor, Embryology and Stem Cell Biology, Department of Biomedicine, University of Basel
Location: CRTD, auditorium left
Host: Federico Calegari

About the research of Prof. Taylor:

The mammalian brain has a remarkable capacity for plasticity, critical for learning and memory and compensating for damage. However, the brains of mammals regenerate poorly, failing to generate appreciable numbers of new neurons. This was thought to be due to a lack of stem and progenitors cells in the postnatal brain, including in humans. It is accepted that the adult brain contains neural stem cells (NSCs) and in some species continue to generate neurons. Newborn adult neurons in the lateral forebrain and in the hippocampus contribute to olfaction and specific forms of memory, respectively. Using conditional mouse genetics and cell culture we are trying to understand the molecular mechanisms controlling NSC activity and fate during development and adulthood. We are also trying to elucidate why active NSCs are lost in infant humans and during aging.



(1) Knuckles, P., Vogt, M.A., Lugert, S., Milo, M., Chong, M.M.W., Hautbergue, G.M., Wilson, S.A., Littman, D.R., and Taylor, V. (2012). Drosha regulates neurogenesis by controlling Neurogenin2 expression independent of microRNAs.  Nature Neuroscience. 15, 962-969. 
(2) Giachino, C., Basak, O., Lugert, S., Knuckles, P., Obernier, K., Fiorelli, R., Frank, S., Raineteau, O., Alvarez-Buylla, A., and Taylor, V. (2014). Molecular diversity subdivides the adult forebrain neural stem cell population. Stem Cells 32, 70-84.
(3) Basak, O., Giachino, C., Fiorini, E., MacDonald, H.R., and Taylor, V. (2012). Neurogenic subventricular zone stem/progenitor cells are Notch1-dependent in their active but not quiescent state J Neurosci. 32, 5654-5666.   (4) Lugert, S., Vogt, M., Tchorz, J.S., Müller, M., Giachino. C. and Taylor, V. (2012). Homeostatic neurogenesis in the adult hippocampus does not involve amplification of Ascl1high  intermediate progenitors. Nature Communications 3, 670.
(5) Lugert, S., Basak, O., Knuckles, P., Häussler, U., Haas, C., Fabel, K., Goetz, M., Kempermann, G., Taylor, V. * and Giachino. C. (2010). Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. Cell Stem Cell, 6:445-456. (*senior and corresponding author).

CRTD External Seminar 06.11.2015

CRTD External Seminar

Date:06.11.2015, 11:00 - 12:00
Speaker: Fiona Doetsch, Biozentrum, University of Basel, Switzerland
Location: CRTD, auditorium left
Host: Caghan Kizil

Genetics and the Importance of Nomenclature for Research Mice & "The Functions and Applications of Alzet Osmotic Pumps in Experimental Research"

Charles River Seminar

Date:09.11.2015, 13:00 - 17:00
Speaker: Jutta Davidson,
Charles River
Location: CRTD, Seminar Room 1 & 2
Host: Katrin Spekl
Category: General

CRTD External Seminar 12.11.2015

CRTD External Seminar

Date:12.11.2015, 16:00 - 17:00
Speaker: José-Alain Sahel, Vision Institute, Paris, France
Location: CRTD, auditorium left
Host: Marius Ader

BIOTEC Green Seminar 13.11.2015

BIOTEC Green Seminar

Date:13.11.2015, 11:00 - 12:00
Speaker: Prof. Helmut Schiessel, Universiteit Leiden, Theoretical Physics of Life Processes
Location: CRTD, auditorium left
Host: Jochen Guck
Category: Green Seminar

BIOTEC Green Seminar 11.12.2015

BIOTEC Green Seminar

Date:11.12.2015, 11:00 - 12:00
Speaker: Prof. Moritz Helmstaedter, Max-Planck-Institute for Brain Research, Department of Connectomics
Location: CRTD, auditorium left
Host: Carlo V. Cannistraci
Category: Green Seminar

Pioneers in Science 11.12.2015

Pioneers in Science

Date:11.12.2015, 14:00 - 15:00
Speaker: Prof. Eric Warrant, Lund University, Department of Biology, Sweden
Location: CRTD, auditorium left
Host: Cristina Golfieri

Stem Cell Models of Neural Regeneration and Disease

ISSCR International Symposia 2016

Date:01.02.2016, 08:00 - 03.02.2016, 17:00
Location: CRTD
Host: Elly Tanaka

Stem Cell Models of Neural Regeneration and Disease will highlight the latest directions of neural stem cell research, including emerging techniques in model systems, that are moving the field to new understandings of disease and toward therapeutic applications. Hear from leaders in neural stem cell biology and neurodegenerative disorders, those who model neural regeneration, and  those who are driving stem-cell based products into clinical trials.


Confirmed Speakers:

- Oliver Brüstle, MD University of Bonn and LIFE & BRAIN GmbH, Germany

- Doo Yeon Kim, PhD, Massachusetts General Hospital/ Harvard Medical School, USA

- Juergen A. Knoblich, PhD, IMBA-Institute of Molecular Biotechnology, Austria

- Mototsugu Eiraku, PhD, Center for Developmental Biology, RIKEN, Japan
- Frederick J. Livesey, PhD, Gurdon Institute, United Kingdom

- Guo-Li Ming, MD, PhD, Johns Hopkins University, USA

- Lawrence S.B. Goldstein, PhD, University of California - San Diego, USA

- Ana Martin-Villalba, MD, PhD DKFZ German Cancer Research Center, Germany

- Frank Bradke, PhD, German Center for Neurodegenerative Diseases (DZNE), Germany

- Jonas Frisén, MD, PhD, Karolinska Institute, Sweden

- Robin Franklin, PhD, Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, United Kingdom

- Steven A. Goldman, MD, PhD, University of Copenhagen, Denmark

- Malin Parmar, PhD, Lund University, Sweden

- Lorenz Studer, MD, Sloan-Kettering Institute for Cancer Research, USA

- Sally Temple, PhD, Neural Stem Cell Institute, USA

- Peter Coffey, BSc, DPhil, University College London Institute of Ophthalmology, United Kingdom

- Elly Tanaka, Center for Regenerative Therapies Technische Universität Dresden, Germany

Category: General


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