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Events


Mechanical stress in microelectronics: a blessing or a curse?

Lecture Series on Nanoscience and Nanotechnology

Date:10.05.2016, 17:00 - 19:00
Speaker: Prof. Ingrid De Wolf (IMEC & KU Leuven, Belgium)
Location: BIOTEC, seminar rooms E05/E06

Broadcasted from KU Leuven, Belgium

Category: General


Optische Pinzetten: Moleküle in der Lichtzange

Dresdner Seniorenakademie

Date:11.05.2016, 10:00 - 11:30
Speaker: Christoph Ehrlich
Location: CRTD, Seminarraum 3
Host: Franziska Clauß


Next Generation Sequencing Illumina Seminar

Advances in Genome Science

Date:11.05.2016, 12:00 - 16:15
Speaker: Daniel Heisswolf (Illumina),
Prof. Dr. med. Christian Thiede (MK I),
Dr. med. Barbara Klink (CMTD),
Dr. Andreas Dahl (BIOTEC, CRTD)
Location: CRTD, Seminar room 3
Category: General


Exploring Primary Cilia Functions by APEX-based Proximity Labeling

BIOTEC External Seminar

Date:13.05.2016, 11:00 - 12:00
Speaker: David Mick, PhD (Stanford University School of Medicine, Dept. of Molecular and Cellular Physiology, Stanford, USA)
Location: CRTD, Auditorium left
Host: Joerg Mansfeld

Abstract:

The primary cilium is a central signaling hub that provides a special compartment by dynamically concentrating signaling molecules to generate adequate responses to external stimuli. To fulfill this function, cilia require specific trafficking machineries that enable rapid changes of the ciliary protein content in response to various signals. Yet, the extent of the signaling functions regulated by mammalian cilia remains unclear because of the limited means to identify ciliary proteins in an unbiased and highly sensitive manner.

To overcome our inability to purify primary cilia with classic biochemical purification methods, we established a proximity labeling approach using cilia-targeted ascorbate peroxidase (cilia-APEX) to specifically biotinylate ciliary proteins in living cells allowing effective isolation and identification by mass-spectrometric methods. Besides identifying known and novel cilia-resident proteins, cilia-APEX uncovered PKA and AMPK as signaling kinases that constantly survey the ciliary interior. Furthermore, proteomics profiling of Ift27/Bbs19 mutant cilia correctly detected BBSome accumulation inside Ift27-/- cilia and revealed that β‑arrestin 2 and the viral receptor CAR are candidate cargoes of the BBSome. Our work demonstrates that proximity labeling can be applied to proteomics of non-membrane-enclosed organelles and suggests that proteomics profiling of cilia will enable a rapid characterization of ciliopathies. Expanding this powerful methodology to explore the temporal protein distribution in cilia under different physiological conditions will provide insights into how the cilium generates its unique signaling environment.



Publications

Mick, D. U., Rodrigues, R. B., Leib, R. D., Adams, C. M., Chien, A. S., Gygi, S. P., and Nachury, M. V. (2015) Proteomics of Primary Cilia by Proximity Labeling.
Dev. Cell 35, 497-512.

Mick, D. U.*, Dennerlein, S.*, Wiese, H., Reinhold, R., Pacheu-Grau, D., Lorenzi, I., Sasarman, F., Weraarpachai, W., Shoubridge, E. A., Warscheid, B. and Rehling, P. (2012). MITRAC links mitochondrial protein translocation to respiratory chain assembly and translational regulation.
Cell 151, 1528-1541.

Reinhold, R., Bareth, B., Balleininger, M., Wissel, M., Rehling, P. and Mick, D. U. (2011). Mimicking a SURF1 allele reveals uncoupling of cytochrome c oxidase assembly from translational regulation in yeast.
Hum. Mol. Genet. 20, 2379-2393.

Mick, D. U., Vukotic, M., Piechura, H., Meyer, H. E., Warscheid, B., Deckers, M. and Rehling, P. (2010). Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria.1
 J. Cell Biol. 191, 141-154.

Bauerschmitt, H.*, Mick, D. U.*, Deckers, M., Vollmer C., Funes S., Kehrein K., Ott M., Rehling P. and Herrmann, J. M. (2010). Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation.
Mol. Cell. Biol. 21, 1937-1944.



10th CRTD Summer Conference on Regenerative Medicine


Date:03.06.2016, 09:00 - 16:00
Speaker: Henrik Semb (University of Copenhagen, Denmark),
Didier Stainier (Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany)
Location: CRTD
Host: Elly Tanaka

The program will include talks of great scientists, presentations of last years postdoctoral seed grants awardees as well as several short poster teasers in the morning followed by the poster sessions in the afternoon. Of course this will be followed by our legendary Summer Party as social event in the yard of the CRTD / BIOZ.

Confirmed speakers:
Henrik Semb, University of Copenhagen, Denmark
Didier Stainier, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany

New interactive poster session

- An online abstract book will be available to all registrants.
- Posters will be arranged by research areas.
- All posters will be presented within 5 minute slots in parallel poster sessions.
- CRTD will award postdoctoral seed grants based on interactions of poster participants (max. 15.000 EUR). Please use the abstract book to prepare yourself and the breaks at the poster session to start discussing putative projects and collaborations. Submit a proposal online until 15.08.2016 to Andrea Meinhardt (andrea.meinhardt(at)crt-dresden.de). Upon positive evaluation the applicants can start their project on 01.10.2016.


Submit your abstract to make this conference a fruitful experience!
Submission deadline: 09 May 2016!  
Please find attached the "Call for Posters".

You will find all necessary information here: https://www.crt-dresden.de/summer2016.

This site is regularly updated and can also be used to upload your poster abstracts.



Single cell decision-making: Of Conformists, Rebels & Individualists

DIPP Vision Talk

Date:14.06.2016, 16:00 - 17:00
Speaker: Jörg Mansfeld (BIOTEC)
Location: CRTD, Auditorium
Category: General, Biology


Eine kleine Geschichte der Mikroskopie

Dresdner Seniorenakademie

Date:15.06.2016, 10:00 - 11:30
Speaker: Dr. Ruth Hans
Location: CRTD, Seminarraum 3
Host: Franziska Clauß


TUD Summer University


Date:19.07.2016, 14:30 - 16:00
Location: CRTD

TUD Summer University enables prospective students interested in math, computer science, natural science and technology (MINT) getting to know student life. They gain insights into study, research and professions of MINT-fields in Dresden.

 
Program:

14.30-14.40 Introduction CRTD (seminar room 3)
14.40-15.15 Talk & discussion: „Selfmade Retina – New chances for research and therapy“ (with Predoc Manuela Völkner & group leader Dr. Mike Karl; seminar room 3)
15.15-15.30 Tour through the axolotl facility
15.30-15.45 Job description „Operator“ (Flow Cytometry Core Facility)
15.45-16.00 Job description „Researcher”


Further information:

https://tu-dresden.de/studium/vor_dem_studium/uni-testen/sommeruni

Category: General


Die Vermessung des Denkens

Dresdner Seniorenakademie

Date:17.08.2016, 10:00 - 11:30
Speaker: Dr. Alexander Garthe
Location: CRTD, Auditorium
Host: Franziska Clauß


Futter für das Denken: der Zusammenhang zwischen Ernährung und Hirnfunktion

Dresdner Seniorenakademie

Date:07.09.2016, 10:00 - 11:30
Speaker: Prof. Dr. Gerd Kempermann
Location: CRTD, Seminarraum 3
Host: Franziska Clauß

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