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Events


Alzheimer's disease, from cellular models to human patients.

CRTD External Seminar

Date:27.05.2016, 11:30 - 12:30
Speaker: Prof. Christian Haass (Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität, Munich)
Location: CRTD, auditorium left
Host: Dr. Jared Sterneckert

About the research of Prof. Haass:

Alzheimer’s disease (AD) is the most common neurodegenerative disorder and threatens our ageing society.  Pathologically, AD is characterized by the accumulation of Amyloid plaques, composed of Amyloid ß-peptide (Aß).  Aß is generated by proteolytic processing from its precursor.   ß-Secretase cleaves first a the N-terminus of the Aß domain and the remaining stub is then re-cleaved by g-secretase to liberate Aß.  I will present data, which indicate important biological functions of ß-scretase in myelination, muscle spindle formation and neuronal function.  Moreover, a novel proteolytic processing pathway, which we discovered recently, suggests that pharmacological inhibition of ß-secretase may silence neuronal activity.  In the second part, I will demonstrate very recent findings on a novel inflammatory mechanism, which is probably common for all neurodegenerative disorders.  Here we followed microglia activation with small animal PET and in a very special cohort of patients with dominantly inherited AD (DIAN) with CSF analyses of a novel biomarker for microglial activation.



Publications:

(1) Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Muller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Muller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C (2015) eta-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature: 526 :443-7.

(2) Kleinberger G., Yamanishi Y., Suárez-Calvet M., Czirr E., Lohmann E., Cuyvers E., Struyfs H., Pettkus N., Wenninger-Weinzierl A., Mazaheri F., Tahirovic S., Lleó A., Alcolea D., Fortea J., Willem M., Lammich S., Molinuevo J. L., Sanchez-Valle R., Antonell A., Ramirez A., Heneka M., Sleegers K., van der Zee J., Martin J.-J., Engelborghs S., Demirtas-Tatlidede A., Zetterberg H., Van Broeckhoven C., Gurvit H., Wyss-Coray T., Hardy J., Colonna M. & Haass C.  (2014) TREM2 mutations linked to neurodegeneration impair cell surface transport and phagocytosis.  Science Translational Medicine, 6, 1-29.

(3) Willem, M., Garratt, A.N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., DeStrooper, B., Saftig, P.,Birchmeier, C. and Haass, C. (2006) Control of peripheral nerve myelination by the beta-secretase BACE1. Science 314, 664-6.

(4) Edbauer, D., Winkler, E., Regula, J.T., Pesold, B., Steiner, H. and Haass, C. (2003) Reconstitution of gamma-secretase activity. Nat Cell Biol 5, 486-8.

(5) Haass, C., Schlossmacher, M.G., Hung, A.Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B.L., Lieberburg, I., Koo, E.H., Schenk, D., Teplow, D.B. and et, a.l. (1992) Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359, 322-5.



Laser Capture Microdissection: precise & contact-free isolation

BioDIP Spring Seminar

Date:31.05.2016, 14:30 - 16:00
Speaker: Ulrich Sauer (Zeiss, Munich),
Daniela Richter (PLID),
Mario Brosch (UKD)
Location: MPI-CBG, small auditorium

Program:

Ulrich Sauer (Zeiss, Munich): Introduction

Daniela Richter (PLID): Laser Microdissection on Human Pancreatic Islets

Mario Brosch (UKD): LCM based Omics: a Tool to Understand GI Disease

 

Everybody is very welcome!



10th CRTD Summer Conference on Regenerative Medicine


Date:03.06.2016, 09:00 - 16:00
Speaker: Henrik Semb (University of Copenhagen, Denmark),
Didier Stainier (Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany)
Location: CRTD
Host: Elly Tanaka

The program will include talks of great scientists, presentations of last years postdoctoral seed grants awardees as well as several short poster teasers in the morning followed by the poster sessions in the afternoon. Of course this will be followed by our legendary Summer Party as social event in the yard of the CRTD / BIOZ.

Confirmed speakers:
Henrik Semb, University of Copenhagen, Denmark
Didier Stainier, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany

New interactive poster session

- An online abstract book will be available to all registrants.
- Posters will be arranged by research areas.
- All posters will be presented within 5 minute slots in parallel poster sessions.
- CRTD will award postdoctoral seed grants based on interactions of poster participants (max. 15.000 EUR). Please use the abstract book to prepare yourself and the breaks at the poster session to start discussing putative projects and collaborations. Submit a proposal online until 15.08.2016 to Andrea Meinhardt (andrea.meinhardt(at)crt-dresden.de). Upon positive evaluation the applicants can start their project on 01.10.2016.


Submit your abstract to make this conference a fruitful experience!
Submission deadline: 09 May 2016!  
Please find attached the "Call for Posters".

You will find all necessary information here: https://www.crt-dresden.de/summer2016.

This site is regularly updated and can also be used to upload your poster abstracts.



Vision restoration using natural and engineered light-gated receptor

CRTD Talk

Date:09.06.2016, 10:00 - 11:00
Speaker: Benjamin Gaub, PhD (ETH Zürich, Biophysics group Prof. Müller, Department of Biosystems Science and Engineering (D-BSSE), Switzerland)
Location: CRTD, auditorium left
Host: Volker Busskamp

Benjamin Gaub about his reserach:

Most inherited forms of human blindness are caused by mutations that lead to photoreceptor cell death, but spare the inner retina, providing an opportunity for treatment. Using viruses as gene delivery vehicles, we expressed light-gated proteins in the remaining neurons of the retina. We asked if these cells would then function as the new photoreceptors and if they would be able to drive visual responses. The quick answer is: yes, they do.

In blind mice, we compared the ability of different target cells to act as new photoreceptors. Installing light sensors downstream in retinal ganglion cells lead to robust and uniform responses, whereas expression upstream in bipolar cells lead to more diverse activity patterns in response to light. We characterized mammalian proteins as optical actuators and found that light gated ion channels drive fast responses but require very high light intensities whereas G-protein coupled receptors are about 1000x more sensitive to light but at the cost of slow kinetics.

We further extended our studies to dogs and were able to show that our treatment restored light responses in blind rcd1 dog retinas in vitro and was safe and well tolerated in vivo. Our results in both large and small animal models of photoreceptor degeneration provide a path to clinical translation



Single cell decision-making: Of Conformists, Rebels & Individualists

DIPP Vision Talk

Date:14.06.2016, 16:00 - 17:00
Speaker: Jörg Mansfeld (BIOTEC)
Location: CRTD, Auditorium
Category: General, Biology


Eine kleine Geschichte der Mikroskopie

Dresdner Seniorenakademie

Date:15.06.2016, 10:00 - 11:30
Speaker: Dr. Ruth Hans
Location: CRTD, Seminarraum 3
Host: Franziska Clauß


The Cytoskeleton as a Polymer-Network – from Self-Assembly to Living Cells

BIOTEC Green Seminar

Date:17.06.2016, 11:00 - 12:00
Speaker: Sarah Köster (Institute for X-Ray Physics, Georg-August-University, Göttingen)
Location: CRTD, auditorium left
Host: Stephan Grill
Category: Green Seminar


TUD Summer University


Date:19.07.2016, 14:30 - 16:00
Location: CRTD

TUD Summer University enables prospective students interested in math, computer science, natural science and technology (MINT) getting to know student life. They gain insights into study, research and professions of MINT-fields in Dresden.

 
Program:

14.30-14.40 Introduction CRTD (seminar room 3)
14.40-15.15 Talk & discussion: „Selfmade Retina – New chances for research and therapy“ (with Predoc Manuela Völkner & group leader Dr. Mike Karl; seminar room 3)
15.15-15.30 Tour through the axolotl facility
15.30-15.45 Job description „Operator“ (Flow Cytometry Core Facility)
15.45-16.00 Job description „Researcher”


Further information:

https://tu-dresden.de/studium/vor_dem_studium/uni-testen/sommeruni

Category: General


Die Vermessung des Denkens

Dresdner Seniorenakademie

Date:17.08.2016, 10:00 - 11:30
Speaker: Dr. Alexander Garthe
Location: CRTD, Auditorium
Host: Franziska Clauß


Futter für das Denken: der Zusammenhang zwischen Ernährung und Hirnfunktion

Dresdner Seniorenakademie

Date:07.09.2016, 10:00 - 11:30
Speaker: Prof. Dr. Gerd Kempermann
Location: CRTD, Seminarraum 3
Host: Franziska Clauß

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