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Transplantation of Cell Therapeutics into the Retina

CRTD Seminar

Datum:08.11.2019, 15:00 - 16:00
Sprecher: Dr. Boris Stanzel
Ort: CRTD Auditorium right
Gastgeber: Dr. Marius Ader


The retinal pigment epithelium (RPE) plays a pivotal role for the retina and in age-related macular degeneration (AMD), the most common cause of blindness in industrialised societies. The RPE also spearheads developments for cell therapeutics from pluripotent stem cells, whereby their application in AMD may hold the promise of curing the disease. 


1: Stanzel B, Ader M, Liu Z, Amaral J, Aguirre LIR, Rickmann A, Barathi VA, Tan
GSW, Degreif A, Al-Nawaiseh S, Szurman P. Surgical Approaches for Cell
Therapeutics Delivery to the Retinal Pigment Epithelium and Retina. Adv Exp Med
Biol. 2019;1186:141-170. doi: 10.1007/978-3-030-28471-8_6. PubMed PMID: 31654389.

2: Sharma R, Khristov V, Rising A, Jha BS, Dejene R, Hotaling N, Li Y, Stoddard
J, Stankewicz C, Wan Q, Zhang C, Campos MM, Miyagishima KJ, McGaughey D,
Villasmil R, Mattapallil M, Stanzel B, Qian H, Wong W, Chase L, Charles S, McGill
T, Miller S, Maminishkis A, Amaral J, Bharti K. Clinical-grade stem cell-derived 
retinal pigment epithelium patch rescues retinal degeneration in rodents and
pigs. Sci Transl Med. 2019 Jan 16;11(475). pii: eaat5580. doi:
10.1126/scitranslmed.aat5580. Erratum in: Sci Transl Med. 2019 Feb 6;11(478):.
PubMed PMID: 30651323.

3: Stanzel BV, Liu Z, Somboonthanakij S, Wongsawad W, Brinken R, Eter N, Corneo
B, Holz FG, Temple S, Stern JH, Blenkinsop TA. Human RPE stem cells grown into
polarized RPE monolayers on a polyester matrix are maintained after grafting into
rabbit subretinal space. Stem Cell Reports. 2014 Jan 2;2(1):64-77. doi:
10.1016/j.stemcr.2013.11.005. eCollection 2014 Jan 14. PubMed PMID: 24511471;
PubMed Central PMCID: PMC3916756.

4: Liu Z, Yu N, Holz FG, Yang F, Stanzel BV. Enhancement of retinal pigment
epithelial culture characteristics and subretinal space tolerance of scaffolds
with 200 nm fiber topography. Biomaterials. 2014 Mar;35(9):2837-50. doi:
10.1016/j.biomaterials.2013.12.069. Epub 2014 Jan 15. PubMed PMID: 24439407.

5: Binder S, Stanzel BV, Krebs I, Glittenberg C. Transplantation of the RPE in
AMD. Prog Retin Eye Res. 2007 Sep;26(5):516-54. Epub 2007 Mar 6. Review. PubMed
PMID: 17532250.

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