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Exploring the private lives of lipid membranes in single cells and whole organisms

CMCB Life Sciences Seminar

Datum:23.05.2019, 16:00 - 17:00
Sprecher: Dr. Itay Budin, University of California, Berkeley
Ort: CRTD, left auditorium
Gastgeber: Prof. James Saenz

Abstract
Biological systems have evolved a tremendous diversity of lipid components in order to tune the physicochemical properties of their cell membranes. Understanding the functional roles for different lipid species remains a challenge, however, because of limited tools for manipulating membrane composition in vivo. I will present my recent efforts to use a combination of engineering and biophysical approaches to investigate lipid biology in living cells. I will first show how metabolic engineering of lipid biosynthesis has uncovered physiological roles for membrane composition and led to the development of a new quantitative model for cellular respiration. I will then present recent data on ways in which the lipid composition in a dietary microbe (yeast) influences function in an animal model organism (the fruit fly).

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