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Presentation of the Institute of Translational Biomedicine at St. Petersburg State University // Spinal neuroprosthetics

CMCB External Seminars

Datum:28.02.2018, 16:00 - 18:00
Sprecher: Dr. Anastasia Levchenko (St. Petersburg State University Russia, Institute of Translational Biomedicine), Prof. Pavel Musienko (St. Petersburg State University Russia, Institute of Translational Biomedicine)
Ort: CRTD, ground floor, auditorium left
Gastgeber: Ivan Minev, PhD

Dr. Anastasia Levchenko:

Abstract:

 

My primary scientific interest is in discovery and characterization of genetics factors in the etiology of mental illnesses. During my career, I have worked on the genetics of frontotemporal dementia, restless legs syndrome and schizophrenia. Currently, I am beginning a study of molecular consequences of the mutation p.Asn648Ser in beta-catenin that I previously discovered in a schizophrenia case. In another project in preparation I will be using DNA samples from 500 schizophrenia patients and 500 controls to study new regulatory sequences that appeared only in our species, namely Human Accelerated Regions. Also, I am currently coordinating collaboration between the Institute of Translational Biomedicine and the Psychiatric Genomics Consortium, within which we perform a GWAS, using 500 schizophrenia patients and 500 controls from Siberia.

 

5 most important publications:

 

1.       Levchenko A, Kanapin A, Samsonova A, and Gainetdinov RR. Human accelerated regions and other human-specific sequence variations in the context of evolution and their relevance for brain development. Genome Biology and Evolution In Press

2.       Levchenko A, Davtian S, Freylichman O, Zagrivnaya M, Kostareva A, Malashichev Y. Beta-catenin in schizophrenia: possibly deleterious novel mutation. Psychiatry Res 2015 Aug; 228(3): 843-848.

3.       Levchenko A, Davtian S, Petrova N, Malashichev Y. Sequencing of five left-right cerebral asymmetry genes in a cohort of schizophrenia and schizotypal disorder patients from Russia. Psychiatr Genet 2014 Apr;24(2):75-80.

4.       Levchenko A, Montplaisir J-Y, Asselin G, Provost S, Girard SL, Xiong L, Lemyre E, St-Onge J, Thibodeau P, Desautels A, Turecki G, Gaspar C, Dubé M-P, Rouleau GA. Autosomal-dominant locus for RLS in French-Canadians on chromosome 16p12.1. Mov Disord 2009 Jan; 24(1):40-50.

5.       Levchenko A, Provost S, Montplaisir JY, Xiong L, St-Onge J, Thibodeau P, Rivière JB, Desautels A, Turecki G, Dubé MP, Rouleau GA. A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13. Neurology 2006 Sep 12;67(5):900-1.


Prof. Pavel Musienko:

Abstract:

Over the last 15 years we had developed multiple breakthrough research paradigms and models, surgical techniques and experimental setups allowed us to deeply investigate the role of spinal and brainstem circuitries in controlling basic sensorimotor activity. We performed extensive studies on spinal cord injured models that led to the development of effective multi-system neurorehabilitation therapies, including epidural spinal cord stimulation, pharmacological intervention and locomotor robotic training. Recently, we designed soft multimodal neural implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury. Our previous studies have provided specific objectives for the optimization of neuroprosthetic algorithms, testing them on new experimental models of neuromotor disorders, and translation to clinic.

5 most important publications:

Musienko P, van den Brand R, Maerzendorfer O, Larmagnac A, Courtine G.
Combinatory electrical and pharmacological neuroprosthetic interfaces to regain motor
function after spinal cord injury. IEEE Trans Biomed Eng. 2009. 56(11 Pt 2): 2707-11.

Musienko P, van den Brand R, Märzendorfer O, Roy RR, Gerasimenko Y, Edgerton VR, Courtine G.
Controlling specific locomotor behaviors through multidimensional monoaminergic modulation of spinal circuitries.
J Neurosci. 2011;31(25):9264-78.

Musienko P, Heutschi J, Friedli L, den Brand RV, Courtine G.
Multi-system neurorehabilitative strategies to restore motor functions following severe spinal cord injury.
Exp Neurol. 2012 May;235(1):100-9.

Musienko P.E., Deliagina T.G., Gerasimenko Y.P., Orlovsky G.N., Zelenin P.V.
Limb and trunk mechanisms for balance control during locomotion in quadrupeds.
J Neurosci. 2014. 34(16): 5704-16.

Minev I.R., Musienko P., et al.
Electronic dura mater for long-term multimodal neural interfaces.
Science. 2015. 347 (6218):159-163.

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