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Decoding lineage emergence in the lateral plate mesoderm

CMCB Green Seminar

Datum:22.10.2018, 13:00 - 14:00
Sprecher: Christian Mosimann, University of Zurich, Institute of Molecular Life Sciences
Ort: CRTD, auditorium left
Gastgeber: Dr. Nikolay Ninov

Cell fate control from multipotent progenitor cells of key importance to understanding organ formation, origins of congenital defects, and regeneration. We study the emergence of cardiovascular cell fates within the context of mesoderm patterning with cellular, molecular, and evolutionary approaches using zebrafish as principal model. We have uncovered gene-regulatory elements that reveal the developmental stages from earliest cardiovascular prongenitor formation to subsequent organ patterning. Decoding the upstream input for these regulatory elements, we uncovered an ancient molecular program that drives the formation of cardiovascular-competent mesoderm. Our approaches further instruct the discovery and mechanistic follow-up of genotype-phenotype associations in congential cardiovascular diseases.

5 most recent papers
1) Felker A, Prummel KD, Merks AM, Mickoleit M, Brombacher EC, Huisken J, Panáková D, Mosimann C. Continuous addition of progenitors forms the cardiac ventricle in zebrafish. Nat Commun. 2018 May 21;9(1):2001. doi: 10.1038/s41467-018-04402-6.

2) Cantù C, Felker A, Zimmerli D, Prummel KD, Cabello EM, Chiavacci E, et al.. Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/beta-catenin signaling Genes Dev. accepted, in print.

3) Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes. Burger A, Lindsay H, Felker A, Hess C, Anders C, Chiavacci E, Zaugg J, Weber LM, Catena R, Jinek M, Robinson MD, Mosimann C. Development. 2016 Jun 1;143(11):2025-37. doi: 10.1242/dev.134809. Epub 2016 Apr 29.

4) Lindsay H, Burger A, Biyong B, Felker A, Hess C, Zaugg J, Chiavacci E, Anders C, Jinek M, Mosimann C, Robinson MD. CrispRVariants charts the mutation spectrum of genome engineering experiments. Nat Biotechnol. 2016 Jul 12;34(7):701-2. doi: 10.1038/nbt.3628.

5) Mosimann C, Panáková D, Werdich AA, Musso G, Burger A, et al. Chamber identity programs drive early functional partitioning of the heart. Nat Commun. 2015 Aug 26;6:8146. doi: 10.1038/ncomms9146.

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