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September 01 - September 30

10 Einträge gefunden

Startdatum: September 04
04:00 pm 05:00 pm

CliniMACS P..
Startdatum: September 06
09:30 am 12:30 pm


We are happy to invite you to our CliniMACS Prodigy Live-DemoGet insights into the Dresden experience in applying the closed automated Prodigysystem for manufacturing of cellular therapeutics. Learn more about the automated clinical-scale T cell transduction process in afunctionally closed system and get hands-on experience.


09:30 a.m. Introduction to CliniMACS Prodigy features & TCT/ CAR T-Cell Process
Dr. Anja Ziemann & Dr. Thea Böhm, Miltenyi Biotec GmbH

10:30 a.m. Automated expansion of regulatory T cells for treatment of chronic GvHD
Dr. Anke Fuchs, DFG-Center for Regenerative Therapies, TU Dresden

11:00 a.m. Automated manufacturing of universal CAR-T batches in a closed system
Dr. Julia Riewaldt & Dr. Marc Cartellieri, Cellex Treatment GmbH, Dresden

11:30 a.m. CliniMACS Prodigy Live Demo
Tubing Set installation, run of demo process, step by step explanation

Mechanisms ..
Startdatum: September 06
04:00 pm 05:00 pm



"My research focuses on the intrinsic properties of the neural stem cells in the adult mammal hippocampus. Their population size, rate of activation and mitotic potential; their activation-coupled astrocytic differentiation and entry into a senescence with aging...all these characteristics determine the true neurogenic potential of each individual organism. Neurological disorders, especially those associated with neuronal hyperactivation, such as epilepsy, profoundly affect neural stem cell properties affecting neurogenesis. For instance, after seizures, neural stem cells transform into reactive astrocytes abandoning their neurogenic program, an unexpected phenomenon which mechanisms we are currently investigating."

5 most important publications

Sierra A, Martín-Suárez S, Valcárcel-Martín R, Pascual-Brazo J, Aelvoet SA, Abiega O, Deudero JJ, Brewster AL, Bernales I, Anderson AE, Baekelandt V, Maletić-Savatić M, Encinas JM. Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis. Cell Stem Cell. 2015 May 7;16(5):488-503.

Encinas JM, Michurina TV, Peunova N, Park JH, Tordo J, Peterson DA, Fishell G, Koulakov A, Enikolopov G. Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus. Cell Stem Cell. 2011 May 6;8(5):566-79.

Sierra A, Encinas JM, Deudero JJ, Chancey JH, Enikolopov G, Overstreet-Wadiche LS, Tsirka SE, Maletic-Savatic M. Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell. 2010 Oct 8;7(4):483-95.

Eisch AJ, Cameron HA, Encinas JM, Meltzer LA, Ming GL, Overstreet-Wadiche LS. Adult neurogenesis, mental health, and mental illness: hope or hype? J Neurosci. 2008 Nov 12;28(46):11785-91

Encinas JM, Vaahtokari A, Enikolopov G. Fluoxetine targets early progenitor cells in the adult brain. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8233-8.

12th CRTD S..
Startdatum: September 07
09:00 am 05:00 pm



14:20 - 15:00
Prof. Michael Sieweke, CRTD: Beyond Stem Cells: The Macrophage in Aging and Regeneration

15:00 - 15:40
Dr. Julia Voss, Max Planck Institute for the History of Science (MPIWG) Berlin: Darwin's pictures: sketches for a famous theory

16:00 - 16:40
Prof. Michael Jennions, Australian National University, Canberra: A black box approach to sex differences: some fishy stories

16:40 - 17:20
Prof. Richard Morris, The University of Edinburgh: The making and keeping of memory

Do you trus..
Startdatum: September 11
10:00 am 12:00 pm



The Cellula..
Startdatum: September 13
04:00 pm 05:00 pm



"How do complex tissues of multicellular organisms develop in a precise and reproducible manner from initially indistinguishable cells? In most tissues signals - termed morphogens - act as positional cues to control cell fate specification by regulating the transcriptional programme of responding cells. How do cells receive and interpret these signals? How do these signals regulate gene expression and how is the growth, patterning and morphological elaboration of the spinal cord coordinated? What is the underlying logic of the mechanisms and how does this explain the spatial and temporal dynamics of pattern formation? To address these questions, we are taking an interdisciplinary approach involving biologists, physicists and computer scientists. Our focus is on the signalling mechanisms and transcriptional programme that pattern the neural tube. In ventral regions of the caudal neural tube, the secreted molecule Sonic Hedgehog (Shh) forms an extracellular gradient that governs pattern formation and tissue growth. It does this by regulating the expression of a set of genes, notably transcription factors, which control the identity and proliferation of neural progenitors. Using a range of molecular, imaging and modelling approaches that combine single cell resolution dynamic assays of morphogen signaling, cell fate specification, gene regulation and growth we are examining how the gradient of Shh signalling is perceived and interpreted by cells to control gene expression and cell behaviour. We are developing novel computational tools and dynamical systems models to obtain a comprehensive view of neural tube development and to analyze the interdependence between different aspects of pattern formation. For our experimental studies we use a range models including mouse and chick embryos and mouse and human embryonic stem cells."

5 most important publications

Sagner A, Gaber ZB, Delile J, Kong JH, Rousso DL, Pearson CA, Weicksel SE, Melchionda M, Mousavy Gharavy SN, Briscoe J, Novitch BG. (2018). Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics. PLoS Biology 16:e2003127

Zagorski, M; Tabata, Y; Brandenberg, N; Lutolf, MP; Tkačik, G; Bollenbach, T; Briscoe, J and Kicheva, A (2017). Decoding of position in the developing neural tube from antiparallel morphogen gradients. Science 356, 1379-1383

Cohen, M; Page, KM; Perez-Carrasco, R; Barnes, CP and Briscoe, J (2014). A theoretical framework for the regulation of Shh morphogen-controlled gene expression. Development 141, 3868-3878

Gouti, M; Tsakiridis, A; Wymeersch, FJ; Huang, Y; Kleinjung, J; Wilson, V and Briscoe, J (2014). In vitro generation of neuromesodermal progenitors reveals distinct roles for Wnt signalling in the specification of spinal cord and paraxial mesoderm identity. PLOS Biology 12, e1001937

Kicheva, A; Bollenbach, T; Ribeiro, A; Valle, HP; Lovell-Badge, R; Episkopou, V and Briscoe, J (2014). Coordination of progenitor specification and growth in mouse and chick spinal cord. Science 345, 1254927

Startdatum: September 17
04:00 pm 06:00 pm



4:00 - 4:05 pm
Introduction by Martin Bornhäuser (University Hospital Dresden, MK1, Stem Cell lab)

4:05 - 4:30 pm
Tatyana Grinenko (TUD, Ben Wielockx lab, Dept. for Clinical Pathobiochemistry)
"Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice."

4:30 - 5:00 pm
Jovan Mircetic (TUD, Frank Buchholz lab, Medical Systems Biology)
"Building on a new sensor of functional p53 status."

5:00 - 5:30 pm
Ekaterina Balaian (University Hospital Dresden, MK1, MDS Center)
"The Pathophysiology of the osteohematopoietic niche."

5:30 pm onwards
Discussion and social get-together, incl. drinks and snacks

Studying fe..
Startdatum: September 25
04:00 pm 05:00 pm

Evaluation ..
Startdatum: September 26
01:00 pm 02:00 pm


1:00 p.m.

Carlo Cannistraci

Machine learning and network science for complex systems big-data analysis and precision medicine

1:30 p.m.

Alessandro Muscoloni

A nonuniform popularity-similarity optimization (nPSO) model to efficiently generate realistic complex networks with communities

1:45 p.m.

Sara Ciucci

Enlightening discriminative network functional modules behind Principal Component Analysis separation in differential-omic science

Machine lea..
Startdatum: September 26
01:00 pm 02:00 pm

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