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Seite 1 von 2 12 >>

April 01 - April 30

15 Einträge gefunden

Stronger to..
Startdatum: April 05
04:00 pm 05:00 pm

Beschreibung: 

Abstract:

Guy Rutter is Professor and Head of Section of Cell Biology and Functional Genomics at Imperial College London. His research involves understanding signal transduction mechanisms in the pancreatic β-cell with a focus on using functional genomics to dissect the role of genes associated with Type 2 diabetes. After studying for a PhD in Bristol with Dick Denton FRS on mitochondrial Ca2+ signalling, he worked as an MRC travelling Fellow with Claes Wollheim in Geneva and collaboratively with Tullio Pozzan and Rosario Rizzuto in Padua. There, he established new approaches to explore the control of insulin release at the single cell level through the use of recombinant targeted probes. He then returned to Bristol, becoming a full Professor of Biochemistry in 2002, before moving to Imperial College in 2006. He was awarded the Minkowski prize of the EASD in 2004 and gave Diabetes UK's Dorothy Hodgkin Lecture in 2013. His current research is supported by a Wellcome Trust Senior Investigator Award, MRC Programmes, by Diabetes UK and by the European Commission (Horizon 2020, "Rhapsody").

Most important publications:

1. Jones, B., et al. Rutter, G.A.*, Tomas, A. and Bloom, S.R. Targeting GLP-1 receptor trafficking to improve agonist efficacy. Nature Comms, in press. *Co-corresponding author

2. Johnston, N.R., Mitchell, R.K., Haythorne, E., Pessoa, MP, Semplici, F., Ferrer, J., Piemonti, L., Marchetti, P., Bugliani, M., Bosco, D., Berishvili, E., Duncanson, P., Watkinson, M., Broichjhagen, J., Trauner, D., Rutter, G.A.* and Hodson D.J. Beta cell hubs dictate pancreatic islest responses to glucose. Cell Metabolism, 24(3):389-401 (2016). *Co-corresponding author

3. Yavari, A. et al, Rutter, G.A., Smith, M.A., Withers, D.J., Carling, D., Sternick., E.B., Arch, J.R.S., Cawthorne M.A., Watkins, H., Ashrafian, H. Chronic activation of γ2 AMPK induces obesity and reduces beta cell function Cell Metabolism, 23(5):821-36 (2016)

4. Zhao, L., et al, Rutter, G.A., Stenmark, K.R., Aitman, T.J. and Wilkins, M.R. The zinc transporter, ZIP12, regulates the pulmonary vascular response to chronic hypoxia. Nature 524(7565):356-60 (2015)

A novel sna..
Startdatum: April 10
04:00 pm 05:00 pm

Preclinical..
Startdatum: April 12
04:00 pm 05:00 pm

Beschreibung: 

Abstract:

"Loss of retinal pigmented epithelial (RPE) cells is responsible for severe vision impairments in retinal degenerative disorders, such as retinitis pigmentosa. Stem cell-derived RPE cells have shown promise as a cell therapy for treating retinal degeneration in preclinical studies, but long-term positive outcomes require efficient engraftment and survival of the transplanted cells. Taking a step in this direction, we have developed a tissue engineered product comprising human embryonic stem cell (hESC)-derived RPE cells that were grown as sheets on a biological scaffold. Transplantation of these hESC-RPE cell sheets into a rat model of retinal degeneration resulted in greater cell engraftment and survival and improved visual acuity compared to hESC-RPE cells transplanted as cell suspensions. These tissue engineered cell sheets may improve the efficacy of cell therapy for treating retinal degenerative diseases"

5 most important publications:

1. Ben M'Barek K, Habeler W, Plancheron A, Jarraya M, Regent F, Terray A, Yang Y, Chatrousse L, Domingues S, Masson Y, Sahel JA, Peschanski M, Goureau O, Monville C. Clinically compatible human ES-derived RPE cells grafted as an epithelium potentiates vision rescue in dystrophic rodent. Sci Transl Med. 2017 Dec 20;9(421).

2. Ben M'Barek K, Regent F, Monville C. Use of human pluripotent stem cells to study and treat retinopathies. World J Stem Cells. 2015 Apr 26;7(3):596-604.

3. Reichman S, Terray A, Slembrouck A, Nanteau C, Orieux G, Habeler W, Nandrot E, Sahel JA, Monville C, Goureau O. From confluent human iPS cells to self-forming neural retina and RPE cells. PNAS. (2014) 111(23):8518-23.

4. Lustremant C, Habeler W, Plancheron A, Goureau O, Grenot L, de la Grange P,Audo I, Nandrot EF, Monville C. Human induced pluripotent stem cells as a tool to model a form of Leber congenital amaurosis. Cell Reprogram. (2013) 15(3):233-246

5. Habeler W, Ghaleh B , Barthelemy I, Plancheron A, Bizé A, Carlos-Sampedrano C, Chetboul V, Berdeaux A, Pucéat M, Peschanski M, Blot S, Monville C. Direct myocardial implantation of human embryonic stem cells in a dog model of Duchenne cardiomyopathy reveals poor cell survival in dystrophic tissue. JSRM (2011) 7(2): 80-86.

Differentia..
Startdatum: April 12
04:30 pm 05:30 pm

Beschreibung: 

Abstract: Differential dynamic microscopy (DDM) is an increasingly adopted technique that extracts local, multi-scale quantitative information about dynamic samples observed with optical microscopy. The very straightforward DDM approach, originally demonstrated with bright field microscopy of aqueous colloids, has lately been used to probe a variety of other complex fluids and biological systems - including liquid suspensions, soft materials, cells, and tissues - with many different imaging methods, including dark-field, differential interference contrast, wide-field, light-sheet, and confocal microscopy. The number of adopting groups is rapidly increasing and so are the applications. Here, we briefly recall the working principles of DDM, we highlight its advantages and limitations, we outline recent experimental breakthroughs, and we provide a perspective on future challenges and directions.

1. Informat..
Startdatum: April 13
03:00 pm 05:00 pm

Beschreibung: 

WER?
Studierende im Bereich Biologie / Life Sciences, Medizin, Biochemie, Physik und verwandten Fächern mit Interesse an einem englischsprachigen Masterprogramm

WAS?
* Vorstellung des CMCB
* Vorstellung der Studiengänge Molecular Bioengineering, Nanobiophysics, Regenerative Biology and Medicine
* Laborbesuch
* PhD / PostDoc Talk & Beer Hour
* Informelles Get-Together

WIE?
Anmeldung bis 23.3.18 unter:
sandra.mattick@tu-dresden.de

Flowing Act..
Startdatum: April 17
05:00 pm 06:15 pm

Using light..
Startdatum: April 17
06:15 pm 07:30 pm

Nanopore se..
Startdatum: April 18
01:00 pm 02:00 pm

Public Sele..
Startdatum: April 19
09:00 am 01:00 pm

Beschreibung: 

Location: BIOTEC at BioInnovationsZentrum, 5th floor, Conference Room 1 and 2, Tatzberg 47-49, 01307 Dresden

 

 

 

9:00 am

Welcome by Prof. Nils Kröger

9:10 am

Simon Alberti

Organizing living matter: the role of phase transitions in cell biology and disease

9:40 am

Thomas Becker

Essential for life – protein biogenesis in mitochondria

10:10 am

Henrik Bringmann

A molecular understanding of sleep

10:40 am

Benoit Kornmann

Organelle contact sites: what are they, what are they good for, and how can they be bad

11:10 am

Coffee/Tea break

11:30 am

Sascha Martens

Mechanisms of Selective Autophagy

12:00 pm

Sabine Schneider

Structure-function relationship of nucleic acids

12:30 pm

David Teis

Selective membrane protein degradation pathways and metabolism

1:00 pm

Lunch

 

In case of questions please contact:

Phone: +49 (0) 351 463 40054 (Janett Schuster) or 40050 (Dana Schoder)

E-mail: Janett.Schuster@tu-dresden.de or Dana.Schoder@tu-dresden.de

Symposium “..
Startdatum: April 20
09:00 am 12:35 pm

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