Examplepictures of DNA-Structures
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Seite 1 von 1 1

December 01 - December 31

3 Einträge gefunden

The emergin..
Startdatum: December 03
03:00 pm 04:00 pm

Behind the ..
Startdatum: December 10
01:00 pm 02:00 pm

Beschreibung: 

Abstract:
"In this informal talk, I will give an overview of how the publishing process works, including some tips on navigating the system. I will also discuss my take on the current publishing ecosystem (including innovations in peer review, Open Science & Open Access, preprints, research assessment) and its likely future directions."

Transcripto..
Startdatum: December 17
11:00 am 12:00 pm

Beschreibung: 

Abstract:
"Patients with rare diseases such as monogenetic cardiomyopathies are in desperate need for drugs targeting their disease. The cost of drug development from initial concept to FDA approval has been estimated to be about 2.6 billion USD.  With high throughput transcriptomics the Library of Integrated Network-based Cellular Signatures (LINCS) has publicly released transcriptional profiles quantifying the effects of more than 25,000 perturbagens on the expression of 978 genes in up to 77 cell lines. We have cross-referenced drugs across the whole database ending up with 1.3 billion data points. With this strategy we identified drugs to target the consequences of Lamin A/C haploinsufficiency causing dilated cardiomyopathy with severe arrhythmogenicity. These drugs which have already been approved for the use in humans and can be repurposed. This approach comes at a fraction of the cost of traditional drug development through transcriptional matching the disease to the drugs in the database and sequential testing of the candidate drugs against iPSC derived cardiomyocytes from healthy and diseased humans."  

Publications:
1: Milliron HY, Weiland MJ, Kort EJ, Jovinge S. Isolation of Cardiomyocytes
Undergoing Mitosis with Complete Cytokinesis. Circ Res. 2019 Oct 25.
 
2: Li G, Tian L, Goodyer W, Kort EJ, Buikema JW, Xu A, Wu JC, Jovinge S, Wu SM.
Single cell expression analysis reveals anatomical and cell cycle-dependent
transcriptional shifts during heart development. Development. 2019 Jun
14;146(12).
 
3: Kort EJ, Jovinge S. Streamlined analysis of LINCS L1000 data with the slinky
package for R. Bioinformatics. 2019 Sep 1;35(17):3176-3177.
 
4: Marinković G, Grauen Larsen H, Yndigegn T, Szabo IA, Mares RG, de Camp L,
Weiland M, Tomas L, Goncalves I, Nilsson J, Jovinge S, Schiopu A. Inhibition of
pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves
cardiac function after myocardial infarction. Eur Heart J. 2019 Aug
21;40(32):2713-2723.

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