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Newborn genetic screening and a primary prevention strategy for Type 1 Diabetes- the Freder1k and POInT study // Cell death in adult hippocampal neurogenesis is ferroptotic and rescued by selenium

CMCB Postdoc seminar

Datum:27.04.2018, 16:00 - 17:00
Sprecher: Ezio Bonifacio, Angela Hommel (Postdoc) // Gerd Kempermann, Tara Walker (Postdoc)
Ort: CRTD, auditorium left

Abstract 1st talk:

The incidence of childhood type 1 diabetes continues to increase. The vision is to stop this. Therefore, a Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) was initiated. Currently GPPAD runs the Freder1k and the POInT study. Within the Freder1k study, neonates who are at increased risk to develop type 1 diabetes can now be identified within the newborn screening using a type 1 diabetes genetic score. The identified newborns have a greater than 10% risk for pre-symptomatic type 1 diabetes. These families are informed about the meaning of an elevated risk for type 1 diabetes, educated about symptoms of the disease as well as asked to participate in a randomized controlled trial aiming to prevent type 1 diabetes. In this trial called POInT (primary oral Insulin trial), children receive a daily dose of insulin powder orally to introduce immune tolerance to insulin aiming to prevent type 1 diabetes and create a world without 1 (type 1 diabetes that is). The program will screen over 300,000 newborns to recruit over 1000 babies into the trial that lasts for 7.5 years.

Abstract 2nd talk:

Apoptotic cell death is a key mechanism controlling the generation of new neurons in the adult hippocampus, a brain region important for learning and memory. We show here that ferroptosis, a recently-discovered form of programmed cell death with as yet unknown physiological functions, explains the first wave of cell death at the precursor cell stage of neurogenesis. Reduction of ferroptosis by exogenous selenium increased neurogenesis in the hippocampus but not the subventricular zone, another adult neural stem cell niche. This suggests a mechanism whereby external stimuli including physical activity increase hippocampal but not subventricular zone neurogenesis. We propose that ferroptotic elimination maintains an expandable reservoir of neural precursor cells that is sensitive to the environmental regulation of adult hippocampal neurogenesis.

Chip/Tissue-Cytometry 100-plex cytometry in research and clinical trial support in immunology

Datum:02.05.2018, 13:00 - 14:00
Sprecher: Dr. Nancy Stanlowsky, Dr. Illip Burmester
Ort: CRTD, Seminar room 3
Gastgeber: Karsten Kretschmer

Chipcytometry has a number of features that are quite similar to conventional flow cytometry with three additional features making Chipcytometry an exciting NEW biomarker technology:

1. Long-term sample storage/ No sample consumption: Chipcytometry uses small microfluidic chips enabling long-term storage of clinical samples for a period of up to 24 months. Cell storage is particularly useful for precious samples like patient samples, rare cells and sorted cells and clinical trial samples.

2. High-Content Cytometry: Chipcytometry enables highly multiplexed biomarker assays. Zellkraftwerk recently has launched a 100-plex panel for human immune cell phenotyping.

3. Tissue Cytometry: Chipcytometry can work with liquid specimens as well as with all tissue types. Based on Chipcytometry you can set-up highly multiplexed tissue biomarker assays (e.g. 30-plex) within only days.

The seminar will cover an introduction to the technology, workflow and data from academic and industrial customers. Zellkraftwerk currently supports 9 phase I, 5 phase II and a number of translational trials in North America, South America, Europe and Asia.

Kategorie: Generalen

Adult Neurogenesis 2018

Datum:02.05.2018, 15:00 - 04.05.2018, 16:00
Sprecher: Nora Abrous, Laure Bally-Cuif, Benedikt Berninger, Michael Brand, Federico Calegari, Fred H. Gage, Sebastian Jessberger, H. Georg Kuhn, Alejandro Schinder, Jason Snyder, Sandrine Thuret, Henriette van Praag
Ort:CRTD / DFG-Zentrum für Regenerative Therapien Dresden -
Fetscherstraße 105
01307 Dresden
Gastgeber: Gerd Kempermann

Next-Generation Proteomics - presented by BRUKER

Datum:07.05.2018, 13:30 - 15:30
Ort: CRTD, seminar rooms 3 + 4
Gastgeber: Marc Gentzel

"Bruker introduces the timsTOF Pro mass spectrometer, using proprietary trapped ion mobility spectrometry (TIMS) technology for higher-speed, higher- sensitivity and robust shotgun proteomics with outstanding single-shot peptide and protein identification performance.The dual TIMS analyzer allows ion to be accumulated in parallel in the first TIMS section while ions are released from the second TIMS section. This results in nearly 100% duty cycle. Moreover due to the time and space focusing of ions the timsTOF Pro provides high sensitivity. Deep proteome coverage can be achieved while using low sample amounts (<< 200 ng)."


13:30 - 13:45 Bruker Daltonik overview (Dr. Stephan Kuehne, Bruker Daltonik GmbH, Bremen)

13:45 - 14:15 timsTOF Pro with PASEF: Dig deeper into the proteome with less sample amount (Dr. Scarlet Beck, Market Manager bottom-up proteomics, Bruker Daltonik GmbH, Bremen)

14.15 - 14.45 The promise of PASEF: Applications in shotgun proteomics (Dr. Scarlet Beck, Market Manager bottom-up proteomics, Bruker Daltonik GmbH, Bremen)

14:45 - 15:15 Q&A session


Contact: Dr. Marc Gentzel

Superconducting nano detectors: from terahertz to infrared

Capita Selecta of Nanoscience and Nanotechnology

Datum:08.05.2018, 17:00 - 19:00
Sprecher: Dr. Cherednichenko Serguei, Chalmers University of Technology, Sweden
Ort: BIOTEC Seminar room E05/ Broadcast from Chalmers
Gastgeber: Prof. Thilo Bauch, Chalmers

Design-Technology Co-optimization for advanced nodes: from scaling boosters to 3D Logic

Capita Selecta of Nanoscience and Nanotechnology

Datum:15.05.2018, 17:00 - 19:00
Sprecher: Dr. Julien Ryckaert, Imec, Belgium
Ort: BIOTEC Seminar room E05/ Broadcast from Leuven
Gastgeber: Prof. Jo De Boeck, KU Leuven

Die Genschere CRISPR/Cas9: Allheilmittel oder Büchse der Pandora


Datum:16.05.2018, 10:00 - 11:30
Sprecher: Dr. Stefan Görlich
Ort: CRTD, Auditorium links
Gastgeber: Franziska Clauß

2. Dresdner Aktionstag Demenz

Datum:16.05.2018, 15:00 - 20:00
Ort: CRTD Auditorium + Foyer
Gastgeber: Franziska Clauß

Carbon nanoobjects: a wide source of new conductors and semi-conductors for electronics and energy

Capita Selecta of Nanoscience and Nanotechnology

Datum:22.05.2018, 17:00 - 19:00
Sprecher: Dr. Pascale Chenevier, CEA-Grenoble at Univ. Grenoble Alpes, France
Ort: BIOTEC Seminar room E05/ Broadcast from Grenoble
Gastgeber: Prof. David Ferrand, Université Grenoble Alpes

(Auflösungs)Grenzen moderner Lichtmikroskope


Datum:30.05.2018, 10:00 - 11:30
Sprecher: Dr. Ruth Hans, Dr. Hella Hartmann, Ellen Geibelt
Ort: CRTD Seminarraum 3
Gastgeber: Franziska Clauß

Lange Nacht der Wissenschaften

Datum:15.06.2018, 18:00 - 16.06.2018, 01:00
Ort: CRTD (Hörsaal, Foyer, Seminarräume, Postersession Areas)
Gastgeber: Franziska Clauß


Kreisläufe des Lebens – im Auge


Datum:20.06.2018, 10:00 - 11:30
Sprecher: Dr. Dominic Eberle
Ort: CRTD Auditorium, links
Gastgeber: Franziska Clauß

Fette Forschung – warum das unbeliebte Fett so interessant für Wissenschaftler ist


Datum:11.07.2018, 10:00 - 11:30
Sprecher: Dr. Grzegorz Chwastek
Ort: CRTD, Auditorium links
Gastgeber: Franziska Clauß

Vom Labor bis zur Tablette


Datum:25.07.2018, 10:00 - 11:30
Sprecher: Dr. Sara Bragado Alonso
Ort: CRTD, Auditorium links
Gastgeber: Franziska Clauß

Therapie von Netzhautdegenerationen durch Zelltransplantation – Forschungen mit der Maus als Modell


Datum:22.08.2018, 10:00 - 11:30
Sprecher: Prof. Dr. Marius Ader, MSc Suse Wiedemann
Ort: CRTD, Auditorium links
Gastgeber: Franziska Clauß


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