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Piconewton-sensitive biosensors to investigate adhesion mechanics in cells

CMCB Life Sciences Seminar

Datum:24.10.2019, 16:00 - 17:00
Sprecher: Prof. Carsten Grashoff, University of Münster
Ort: CRTD, ground floor, auditorium left
Gastgeber: Dr. Gokul Kesavan (CRTD)

Abstract
To investigate the molecular mechanisms underlying cell adhesion mechanics, we developed a set of single-molecule‒calibrated biosensors that are sensitive to physiologically relevant forces in the low piconewton range. These biosensors are genetically encoded and can be utilized to determine molecular forces acting across individual molecules in cells. In my seminar, I will describe how their application to the focal adhesion protein talin and the desmosomal molecule desmoplakin revealed fundamental differences in how distinct adhesion molecules modulate intracellular force transduction.

5 most important publications
1. Price AJ, Cost AL, Ungewiβ H, Waschke J, Dunn AR, and Grashoff C. 2018. Nat Commun 11; 9:5284.
2. Ringer, P. Weißl, A., Cost, A.L., Freikamp, A., Sabass, B., Mehlich, A., Tramier, M., Rief, M. and Grashoff, C. 2017. Nat Methods 14: 1090-1096.
3. Austen KA, Ringer P, Mehlich A, Chrostek-Grashoff A, Kluger C, Klingner C, Sabass B, Zent R, Rief M, and Grashoff C. 2015. Nat Cell Biol 17: 1597-1606.
4. Hoffman BD, Grashoff C, and Schwartz MA. 2011. Nature 475(7356): 316-323.
5. Grashoff C, Hoffman BD, Brenner MD, Zhou R, Parsons M, Yang MT, McLean MA, Sligar SG, Chen CS, Ha T, and Schwartz MA. 2010. Nature 466(7303): 263-266.

Everybody is very welcome!

Kategorie: Generalen, CMCB LifeScience Seminar


Technology for Organoids

CRTD - RAC F Symposium

Datum:28.10.2019, 16:00 - 18:00
Sprecher: Prof. Carsten Werner, Byung Ho Lee, Valentina Magno, Andrea Meinhardt, Daniel Stange
Ort: CRTD, auditorium left
Gastgeber: Prof. Carsten Werner

CRTD Symposium
Technology for Organoids

4:00 - 4:05 Introduction by Carsten Werner

4:05 - 4:25 Byung Ho Lee, Max Planck Institute of Cell Biology and Genetics Dresden
The Influence of Mechanical Cues on Pancreatic Organoid Branching

4:25 - 4:45 Valentina Magno, Leibniz Institute of Polymer Research Dresden
Hydrogels to Modulate the Differentiation of iPSC-derived Kidney Organoids

4:45 - 5:05 Andrea Meinhardt, Leibniz Institute of Polymer Research Dresden
Growth Factor Modulation by Hydrogels to Guide Neuroepithelial Cyst Differentiation

5:05 - 5:35 Daniel Stange, University Hospital Carl Gustav Carus, TU Dresden
Modeling Gastric Cancer using Organoids

5:35 - 6:00 Discussion and social get-together

Kategorie: Generalen


Post-transcriptional regulation of insulin expression in beta-cells & Foxp3+ Regulatory T Cells in Adipose Tissue Homeostasis and Obesity

Diabetes Research Seminar

Datum:29.10.2019, 15:00 - 16:00
Sprecher: Jovana Vasiljevic, Molecular Diabetology & Acelya Yilmazer, Molecular and Cellular Immunology/Immune Regulation, CRTD
Ort: CRTD, seminar room 3
Kategorie: Generalen


Wie alt ist unser menschlicher Körper wirklich?

Seniorenakademie

Datum:30.10.2019, 10:00 - 11:00
Sprecher: Dr. Olaf Bergmann
Ort: CRTD, Auditorium links
Kategorie: Generalen


Transposons and small RNAs during complex regeneration

CRTD Seminar

Datum:06.11.2019, 13:00 - 14:00
Sprecher: Dr. Ahmed Elewa, Cold Spring Harbor Laboratory, USA & Karolinska Institute, Sweden
Ort: CRTD, ground floor, auditorium left
Gastgeber: Dr. Max H. Yun
Kategorie: Generalen


To be announced

CMCB Life Sciences Seminar

Datum:07.11.2019, 16:00 - 17:00
Sprecher: Prof. Dr. Martin Fussenegger, ETH Zürich
Ort: CRTD, ground floor, auditorium left
Gastgeber: Dr. Volker Busskamp
Kategorie: Generalen, CMCB LifeScience Seminar


Wie kann man ein neues Körperteil wachsen lassen? Was wir von Salamandern lernen können

Seniorenakademie

Datum:13.11.2019, 10:00 - 10:45
Sprecher: Dr. Dunja Knapp
Ort: CRTD, Auditorium links
Kategorie: Generalen


To be announced

CMCB Life Sciences Seminar

Datum:14.11.2019, 16:00 - 17:00
Sprecher: Prof. Dr. Carmen Ruiz de Almodovar, Biochemie-Zentrum (BZH), Universität Heidelberg
Ort: CRTD, ground floor, auditorium left
Gastgeber: Dr. Christian Lange

tba

Kategorie: Generalen, CMCB LifeScience Seminar


To be announced

CMCB Life Sciences Seminar

Datum:28.11.2019, 16:00 - 17:00
Sprecher: Prof. Jorge Ferrer, Imperial College London
Ort: CRTD, ground floor, auditorium left
Gastgeber: Dr. Anthony Gavalas

tba

Kategorie: Generalen, CMCB LifeScience Seminar


Evolution im Reagenzglas

Seniorenakademie

Datum:15.01.2020, 10:00 - 11:00
Sprecher: Martin Schneider
Ort: CRTD, Auditorium links

tba

Kategorie: Generalen

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