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Events


POSTPONED: Unleashing the developmental potential of induced pluripotent stem cells (iPSCs)

CMCB Life Sciences Seminar

Datum:02.04.2020, 13:00 - 14:00
Sprecher: Hans Schöler, Department for Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine Münster
Ort: CRTD, ground floor, auditorium right
Gastgeber: Jared Sterneckert

 

5 most important publications:

1. Schöler HR, Ruppert S, Suzuki N, Chowdhury K, Gruss. New type of POU domain in germ line-specific protein Oct-4. Cloning and characterization of the germline-specific octamer binding protein Oct-4. Nature 344:435-9, 1990

2. Hübner K, Fuhrmann G, Christenso, LK, Kehler J, Reinbold, R, De La Fuente R, Wood J, Strauss III J, Boiani M, Schöler HR. Mouse embryonic stem cells in culture give rise to oocytes. Science 300:1251-6, 2003

3. Kim JB, Sebastiano V, Wu G, Araúzo-Bravo M, Sasse P, Gentile L, Ko K, Ruau D, Ehrich M, van den Boom D, Meyer J, Hübner K, Bernemann C, Ortmeier C, Zenke M, Fleischmann B, Zaehres H, Schöler HR. Oct4-induced pluripotency in adult neural stem cells. Cell 136:411-19, 2009

4. Han DW, Tapia N, Hermann A, Hemmer K, Höing S, Araúzo-Bravo MJ, Zaehres H, Wu G, Frank S, Moritz S, Greber B, Yang JH, Lee HT, Schwamborn JC, Storch A, Schöler HR. Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell 10(4):465-72, 2012

5. Velychko S, Adachi K, Kim KP, Hou Y, MacCarthy CM, Wu G, Schöler HR Excluding Oct4 from Yamanaka cocktail unleashes the developmental potential of iPSCs. Cell Stem Cell 25(6):737-753, 2019

Abstract:

A current aim in cell and developmental biology is to program cells at will. One way towards converting a given cell type into another one is achieved via a pluripotent stem cell state that resembles that of embryonic stem cells (ESCs). In most cases, somatic cells are pushed into a pluripotent state by the introduction of exogenous factors, mostly transcription factors. Reprogramming of somatic cells into pluripotent stem cells designated as induced pluripotent stem cells (iPSCs) was first described in 2006. Fibroblasts were used and initially required introduction of the virally expressed transcription factor quartet Oct4, Sox2, Klf4, and c-Myc (OSKM). We previously reported that Oct4 alone is sufficient for directly reprogramming adult mouse and human fetal neural stem cells into iPSCs, thus highlighting the crucial role played by Oct4 in the process. As we now show the combination of SKM is sufficient for reprogramming mouse somatic cells into iPSCs. Actually, SKM even activates the pluripotency network in Oct4-knockout fibroblasts. Retroviral silencing requires the simultaneous expression of Sox2 and c-Myc, perhaps accounting for the discrepancy with respect to previous studies that used retroviral vectors to generate iPSCs without Oct4. Reprogramming in the absence of exogenous Oct4 results in iPSCs that are characterized by more faithful gene expression and greatly improved developmental potential. Our data suggests that expression of exogenous Oct4 during reprogramming leads to off-target gene activation, thereby worsening the quality of the generated iPSCs with major implications for further development and application of iPSC technology.

Everybody is very welcome!

Kategorie: Generalen, CMCB LifeScience Seminar


VERANSTALTUNG FÄLLT LEIDER AUS: Master‘s Courses Information Day


Datum:03.04.2020, 14:00 - 17:00
Sprecher: CMCB student council and the coordinators of the Master's courses
Ort: CRTD
Gastgeber: Sandra Mattick

[Translate to German:] Information Day on International Master‘s Courses at the Center for Molecular and Cellular Bioengineering (CMCB)

FOR WHOM?
Students of biology, life sciences, medicine, bio-chemistry, physics and similar subjects with an interest in an English-language Master’s program

WHAT?
― Introduction of the Master’s courses of study
Molecular Bioengineering, Nanobiophysics,
and Regenerative Biology and Medicine
― Lab visit
― Opportunity to talk to the CMCB student council
(Fachschaftsrat) and the course coordinators
― PhD/PostDoc Talk & Social Hour

WHEN?
April 3, 2 – 5pm

WHERE?
Center for Regenerative Therapies TU Dresden (CRTD)
Fetscherstr. 105, 01307 Dresden
www.tu-dresden.de/cmcb

Please sign-up until March 20 2020:
sandra.mattick(at)tu-dresden.de
Please provide your name, university / course of study, semester.

Flyer

Kategorie: Generalen


VERANSTALTUNG FÄLLT LEIDER AUS: Unsere heimischen Bienen jenseits der Honigbiene

Seniorenakademie

Datum:15.04.2020, 10:00 - 11:30
Sprecher: Dr. Anja Buttstedt
Ort: CRTD, Auditorium links
Kategorie: Generalen


The world's smallest MRI: enhancing magnetic resonance with quantum effects in diamond (Broadcastfrom Leuven, Aud. "De Molen")

Nanoscience and Nanotechnology Seminar Series

Datum:21.04.2020, 17:00 - 19:00
Sprecher: Dr. Kristiaan De Greve, imec, Belgium
Ort: BIOTEC, Seminar Room E05

The lectures are broadcast live to all participating universities using a Virtual Classroom concept in the EMM Nano programme. Find more information here.

Kategorie: Generalen


Are you watching closely? Process control in advanced semiconductor nodes (Broadcast from Leuven, Aud. "De Molen")

Nanoscience and Nanotechnology Seminar Series

Datum:28.04.2020, 17:00 - 19:00
Sprecher: Dr. Hari Pathangi, KLA Corporation, Belgium
Ort: BIOTEC, Seminar Room E05

The lectures are broadcast live to all participating universities using a Virtual Classroom concept in the EMM Nano programme. Find more information here.

Kategorie: Generalen


How to design a superconducting quantum processor (Broadcast from Chalmers)

Nanoscience and Nanotechnology Seminar Series

Datum:05.05.2020, 17:00 - 19:00
Sprecher: Dr. Philip Krantz, Chalmers University of Technology, Sweden
Ort: BIOTEC, Seminar Room E05

The lectures are broadcast live to all participating universities using a Virtual Classroom concept in the EMM Nano programme. Find more information here.

Kategorie: Generalen


Topological quantum materials: From topological insulators to Majorana qubit (Broadcast from Dresden)

Nanoscience and Nanotechnology Seminar Series

Datum:12.05.2020, 17:00 - 19:00
Sprecher: Matthias Vojta, TU Dresden, Germany
Ort: BIOTEC, Seminar Room E05

The lectures are broadcast live to all participating universities using a Virtual Classroom concept in the EMM Nano programme. Find more information here.

Kategorie: Generalen


Wie Fruchtfliegen frieren

Seniorenakademie

Datum:13.05.2020, 10:00 - 11:30
Sprecher: Dr. Marko Brankatschk
Ort: CRTD, Auditorium links
Kategorie: Generalen


Growing mini-tissues and mini-organs on chip (Broadcast from Leuven, Aud. "De Molen")

Nanoscience and Nanotechnology Seminar Series

Datum:19.05.2020, 17:00 - 19:00
Sprecher: Adrian Ranga, Lab. Of Bioengineering & Morphogenesis, KULeuven, Belgium
Ort: BIOTEC, Seminar Room E05

The lectures are broadcast live to all participating universities using a Virtual Classroom concept in the EMM Nano programme. Find more information here.

Kategorie: Generalen


Polarisationsmikroskopie – ein Klassiker, der noch immer Jung und Alt begeistert

Seniorenakademie

Datum:03.06.2020, 10:00 - 11:30
Sprecher: Dr. Ruth Hans, Dr. Hella Hartmann, Ellen Geibelt
Ort: CRTD, Auditorium links
Kategorie: Generalen


4. Life Sciences-Forum Sachsen - 20 Jahre Biotechnologie-Offensive Sachsen

See Website

Datum:10.07.2020, 09:00 - 18:00
Ort: Center for Regenerative Therapies Dresden (CRTD), Fetscherstrasse 105, 01307 Dresden, Germany

 

On behalf of the Saxon State Ministry of Economics, Labour and Transport, Wirtschaftsförderung Sachsen (WFS) cordially invites you to this year's Life Sciences Forum Saxony. The forum is organized in cooperation with the Biotechnology Center of the TU Dresden (BIOTEC) and the Biotechnology-Biomedical Center of the University of Leipzig (BBZ).

This year, the forum is dedicated to the 20th anniversary of the Biotechnology Offensive Saxony. We invite you, together with Minister President Michael Kretschmer, to take a look at the past and the future of Saxony as a biotechnology location.

Please make a note of the date today. You can register for the forum today at www.standort-sachsen.de/lsfs. The number of participants is limited. Detailed information on the event will be sent to you shortly with a separate invitation.

The forum is organized in cooperation with the Biotechnology Center of the TU Dresden (BIOTEC) and the Biotechnology-Biomedical Center of the University of Leipzig (BBZ).

Speakers and program will follow shortly.

Registration: www.standort-sachsen.de/lsfs

Kategorie: Generalen


Antonina Roll-Mecak, The National Institutes of Health (USA)

CMCB Life Sciences Seminar

Datum:12.11.2020, 13:00 - 14:00
Sprecher: Antonina Roll-Mecak, The National Institutes of Health (USA)
Ort: CRTD, ground floor, auditorium left
Gastgeber: Cordula Reuther

Title to be announced. Please note new starting time!

Kategorie: Generalen, CMCB LifeScience Seminar

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