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Active deformation of the cell membrane through actin assembly, and how we may infer nucleus deformation

CMCB Life Sciences Seminar

Date:28.05.2020, 13:00 - 14:00
Speaker: Cécile Sykes, Institut Curie/ PSL/ Sorbonne Université
Location: Zoom Video Conferencing
Host: Elisabeth Fischer-Friedrich

Link to the conference -  Zoom Meeting ID: 934 2705 8190, Password: 175528


We conceive stripped-down experimental systems that reproduce cellular behaviours in simplified conditions: cytoskeleton dynamics are reproduced on liposome membranes. By changing experimentally membrane tension and the structural details of the cytoskeleton architecture, we draw a phase diagram where inward or outward deformations are favoured. We observe buckling and wrinkling under osmotic deflation, thereby confirming network elastic properties. Our results illustrate the generic mechanism of buckling and wrinkling found in various systems spanning from pollen grains to the development of the gut or the brain.

Inspired by actin forces exerted on membranes and organelles, we address now how the nucleus, which is the most rigid cell organelle, is deformed by the actin cytoskeleton during cell translocation.

5 most important publications:

C. Simon, V. Caorsi, C. Campillo, C. Sykes, "Interplay between membrane tension and the actin cytoskeleton determines shape changes",Physical Biology, 5(6):065004, doi: 10.1088/1478-3975/aad1ab. (2018)

A. Allard, M. Bouzid, T. Betz, C. Simon, M. Abou-Ghali, J. Lemière, F. Valentino, J. Manzi, F. Brochard-Wyart, K. Guevorkian, J. Plastino, M. Lenz, C. Campillo*, C. Sykes*, "Actin modulates shape and mechanics of tubular membranes” bioRxiv 712505; doi: https://doi.org/10.1101/712505, and, Science advances in press

C. Simon, R. Kusters, V. Caorsi, A. Allard, M. Abou-Ghali, J. Manzi, A. Di Cicco, D. Lévy, M. Lenz, J.-F. Joanny, C. Campillo, J. Plastino, P. Sens, C. Sykes " Actin dynamics drive cell-like membrane deformation " Nature Physics, https://doi.org/10.1038/s41567-019-0464-1 (2019)

R. Kusters, C. Simon, R. Lopes Dos Santos, V. Caorsi, Sangsong Wu, J.-F. Joanny, P. Sens, C. Sykes, “Actin shells control buckling and wrinkling of biomembranes” Soft Matter, 15, 9647 – 9653 doi: 10.1039/c9sm01902b (2019)

P.M. Davidson, A. Battistella, T. Déjardin, T. Betz, J. Plastino, N. Borghi, B. Cadot, C. Sykes “Actin accumulates nesprin-2 at the front of the nucleus during confined cell migration” bioRxiv 713982; doi: https://doi.org/10.1101/713982, EMBO Reports, in press

Category: General, CMCB LifeScience Seminar

Polarisationsmikroskopie – ein Klassiker, der noch immer Jung und Alt begeistert


Date:03.06.2020, 10:00 - 11:30
Speaker: Dr. Ruth Hans, Dr. Hella Hartmann, Ellen Geibelt
Location: CRTD, Auditorium links
Category: General

4. Life Sciences-Forum Sachsen - 20 Jahre Biotechnologie-Offensive Sachsen

See Website

Date:10.07.2020, 09:00 - 18:00
Location: Center for Regenerative Therapies Dresden (CRTD), Fetscherstrasse 105, 01307 Dresden, Germany


On behalf of the Saxon State Ministry of Economics, Labour and Transport, Wirtschaftsförderung Sachsen (WFS) cordially invites you to this year's Life Sciences Forum Saxony. The forum is organized in cooperation with the Biotechnology Center of the TU Dresden (BIOTEC) and the Biotechnology-Biomedical Center of the University of Leipzig (BBZ).

This year, the forum is dedicated to the 20th anniversary of the Biotechnology Offensive Saxony. We invite you, together with Minister President Michael Kretschmer, to take a look at the past and the future of Saxony as a biotechnology location.

Please make a note of the date today. You can register for the forum today at www.standort-sachsen.de/lsfs. The number of participants is limited. Detailed information on the event will be sent to you shortly with a separate invitation.

The forum is organized in cooperation with the Biotechnology Center of the TU Dresden (BIOTEC) and the Biotechnology-Biomedical Center of the University of Leipzig (BBZ).

Speakers and program will follow shortly.

Registration: www.standort-sachsen.de/lsfs

Category: General

Antonina Roll-Mecak, The National Institutes of Health (USA)

CMCB Life Sciences Seminar

Date:12.11.2020, 13:00 - 14:00
Speaker: Antonina Roll-Mecak, The National Institutes of Health (USA)
Location: CRTD, ground floor, auditorium left
Host: Cordula Reuther

Title to be announced. Please note new starting time!

Category: General, CMCB LifeScience Seminar


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