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Events


Piconewton-sensitive biosensors to investigate adhesion mechanics in cells

CMCB Life Sciences Seminar

Date:24.10.2019, 16:00 - 17:00
Speaker: Prof. Carsten Grashoff, University of Münster
Location: CRTD, ground floor, auditorium left
Host: Dr. Gokul Kesavan (CRTD)

Abstract
To investigate the molecular mechanisms underlying cell adhesion mechanics, we developed a set of single-molecule‒calibrated biosensors that are sensitive to physiologically relevant forces in the low piconewton range. These biosensors are genetically encoded and can be utilized to determine molecular forces acting across individual molecules in cells. In my seminar, I will describe how their application to the focal adhesion protein talin and the desmosomal molecule desmoplakin revealed fundamental differences in how distinct adhesion molecules modulate intracellular force transduction.

5 most important publications
1. Price AJ, Cost AL, Ungewiβ H, Waschke J, Dunn AR, and Grashoff C. 2018. Nat Commun 11; 9:5284.
2. Ringer, P. Weißl, A., Cost, A.L., Freikamp, A., Sabass, B., Mehlich, A., Tramier, M., Rief, M. and Grashoff, C. 2017. Nat Methods 14: 1090-1096.
3. Austen KA, Ringer P, Mehlich A, Chrostek-Grashoff A, Kluger C, Klingner C, Sabass B, Zent R, Rief M, and Grashoff C. 2015. Nat Cell Biol 17: 1597-1606.
4. Hoffman BD, Grashoff C, and Schwartz MA. 2011. Nature 475(7356): 316-323.
5. Grashoff C, Hoffman BD, Brenner MD, Zhou R, Parsons M, Yang MT, McLean MA, Sligar SG, Chen CS, Ha T, and Schwartz MA. 2010. Nature 466(7303): 263-266.

Everybody is very welcome!

Category: General, CMCB LifeScience Seminar


Technology for Organoids

CRTD - RAC F Symposium

Date:28.10.2019, 16:00 - 18:00
Speaker: Prof. Carsten Werner, Byung Ho Lee, Valentina Magno, Andrea Meinhardt, Daniel Stange
Location: CRTD, auditorium left
Host: Prof. Carsten Werner

CRTD Symposium
Technology for Organoids

4:00 - 4:05 Introduction by Carsten Werner

4:05 - 4:25 Byung Ho Lee, Max Planck Institute of Cell Biology and Genetics Dresden
The Influence of Mechanical Cues on Pancreatic Organoid Branching

4:25 - 4:45 Valentina Magno, Leibniz Institute of Polymer Research Dresden
Hydrogels to Modulate the Differentiation of iPSC-derived Kidney Organoids

4:45 - 5:05 Andrea Meinhardt, Leibniz Institute of Polymer Research Dresden
Growth Factor Modulation by Hydrogels to Guide Neuroepithelial Cyst Differentiation

5:05 - 5:35 Daniel Stange, University Hospital Carl Gustav Carus, TU Dresden
Modeling Gastric Cancer using Organoids

5:35 - 6:00 Discussion and social get-together

Category: General


Post-transcriptional regulation of insulin expression in beta-cells & Foxp3+ Regulatory T Cells in Adipose Tissue Homeostasis and Obesity

Diabetes Research Seminar

Date:29.10.2019, 15:00 - 16:00
Speaker: Jovana Vasiljevic, Molecular Diabetology & Acelya Yilmazer, Molecular and Cellular Immunology/Immune Regulation, CRTD
Location: CRTD, seminar room 3
Category: General


Wie alt ist unser menschlicher Körper wirklich?

Seniorenakademie

Date:30.10.2019, 10:00 - 11:00
Speaker: Dr. Olaf Bergmann
Location: CRTD, Auditorium links
Category: General


Transposons and small RNAs during complex regeneration

CRTD Seminar

Date:06.11.2019, 13:00 - 14:00
Speaker: Dr. Ahmed Elewa, Cold Spring Harbor Laboratory, USA & Karolinska Institute, Sweden
Location: CRTD, ground floor, auditorium left
Host: Dr. Max H. Yun
Category: General


To be announced

CMCB Life Sciences Seminar

Date:07.11.2019, 16:00 - 17:00
Speaker: Prof. Dr. Martin Fussenegger, ETH Zürich
Location: CRTD, ground floor, auditorium left
Host: Dr. Volker Busskamp
Category: General, CMCB LifeScience Seminar


Wie kann man ein neues Körperteil wachsen lassen? Was wir von Salamandern lernen können

Seniorenakademie

Date:13.11.2019, 10:00 - 10:45
Speaker: Dr. Dunja Knapp
Location: CRTD, Auditorium links
Category: General


To be announced

CMCB Life Sciences Seminar

Date:14.11.2019, 16:00 - 17:00
Speaker: Prof. Dr. Carmen Ruiz de Almodovar, Biochemie-Zentrum (BZH), Universität Heidelberg
Location: CRTD, ground floor, auditorium left
Host: Dr. Christian Lange

tba

Category: General, CMCB LifeScience Seminar


To be announced

CMCB Life Sciences Seminar

Date:28.11.2019, 16:00 - 17:00
Speaker: Prof. Jorge Ferrer, Imperial College London
Location: CRTD, ground floor, auditorium left
Host: Dr. Anthony Gavalas

tba

Category: General, CMCB LifeScience Seminar


Evolution im Reagenzglas

Seniorenakademie

Date:15.01.2020, 10:00 - 11:00
Speaker: Martin Schneider
Location: CRTD, Auditorium links

tba

Category: General

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